A5039425669- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
- Memory and Neural Mechanisms
- Cognitive Functions and Memory
- Neurobiology of Language and Bilingualism
- Neurogenetic and Muscular Disorders Research
- Traumatic Brain Injury Research
- Optical Imaging and Spectroscopy Techniques
- Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neural and Behavioral Psychology Studies
- Electroconvulsive Therapy Studies
- Parkinson's Disease Mechanisms and Treatments
- Alcoholism and Thiamine Deficiency
- Neuroscience and Neuropharmacology Research
- Autoimmune Neurological Disorders and Treatments
- Health, Nursing, Elderly Care
- Neurological disorders and treatments
- Parasitic infections in humans and animals
- Medical Imaging Techniques and Applications
- Spatial Neglect and Hemispheric Dysfunction
- Frailty in Older Adults
- Advanced Neuroimaging Techniques and Applications
Universidade de São Paulo
2014-2023
Brigham and Women's Hospital
2015-2023
Harvard University
2015-2023
Faculdade de Medicina de Marília
2019-2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2012-2021
Dr. Euryclides Hospital de Jesus Zerbini
2021
Sociedade Brasileira de Neurociências e Comportamento
2001-2020
Hospital de Clínicas de Porto Alegre
2013
Hospital Santa Paula
2012
Universidade Federal Fluminense
2007-2009
Abstract Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, Consortium on Dementia (LAC‐CD) proposes an agenda for integration to deliver Knowledge Action Framework (KtAF). First, we summarize evidence‐based strategies (epidemiology,...
Neuroplasticity can be conceptualized as an intrinsic property of the brain that enables modification function and structure in response to environmental demands. Neuroplastic strengthening synapses is believed serve a critical mechanism underlying learning, memory, other cognitive functions. Ex vivo work investigating neuroplasticity has been done on hippocampal slices using high frequency stimulation. However, humans difficult demonstrate. Recently, long-term potentiation-like phenomenon,...
Background: Aerobic training (AT) is a promising intervention for mild cognitive impairment (MCI). Objective: To evaluate the effects of AT on cognition and regional brain glucose metabolism (rBGM) in MCI patients. Methods: Subjects performed twice-a-week, moderate intensity, program 24 weeks. Assessment with ADAS-cog, comprehensive neuropsychological battery, evaluation rBGM positron emission tomography 18F-fluorodeoxyglucose ([18F]FDG-PET) were before after intervention. capacity was...
Objective We describe the case of a patient who developed an episode catatonia during course her life-long obsessive-compulsive disorder (OCD) and discuss issues related to etiopathogenesis, differential diagnosis, therapeutic management this association. Background Catatonia is conventionally considered heterogeneous syndrome motor dysregulation characterized by mutism, immobility, negativism, posturing (catalepsy), stereotypies, echophenomena. The relationship between OCD still...
It is not easy to differentiate patients with mild cognitive impairment (MCI) from subjective memory complainers (SMC). Assessments screening tools are essential, particularly in primary care where most seen. The objective of this study was evaluate the diagnostic accuracy tests and propose a score derived tests. Elderly subjects complaints were evaluated using Mini Mental State Examination (MMSE) Brief Cognitive Battery (BCB). We added two delayed recalls MMSE (a recall late-delayed recall,...
Background: A possible viral etiology has been documented in the genesis of motor neuron disorders and acquired peripheral neuropathies, mainly due to vulnerability nerves anterior horn certain viruses. In recent years, several reports show association HIV infection with Amyotrophic Lateral Sclerosis – Syndrome, Motor Neuron Diseases neuropathies. Objective: To report a case an between Disease Acquired Axonal neuropathy infection, describe findings neurological examination, cerebrospinal...
Aerobic training (AT) is a promising intervention to improve cognitive functioning. However, its modulatory effects on brain networks are not yet entirely understood. Sixty-five subjects with mild impairment performed moderate intensity, 24-week AT program. Differences in resting regional glucose metabolism (rBGM) FDG-PET were assessed before and after voxel-by-voxel basis. Structural equation modeling was used create latent variables based regions significant rBGM changes test hypothetical...
The syndrome of progressive, ascending or descending hemiplegia, with no significant sensory impairment was first describes by Mills in 1900, which several cases were reported later. However after diagnostic tests and image improvements, the number reports has shortened. A possible explanation for this shortage is identification other diseases that could mimic clinical picture. Currently, an uncertain nosological status, since it described based on examination only. We can find presentation...
A 35-year-old, previously healthy man presented psychiatric symptoms lasting four years, receiving treatment with neuroleptics. One year later he evolved gait disequilibrium. After a further six months, cognitive were characterized rapid evolution to profound demented state. MRI showed signal changes in cerebral white matter and very long-chain fatty acids detected blood.Homem de 35 anos, previamente saudável, iniciou há quatro anos sintomas psiquiátricos, recebendo tratamento com...
ABSTRACT Although not evident clinically, lesions to the prefrontal cortex cause great social and functional impairment patients. The anterior cingulate is intimately involved with motivational behavior after injury this area onset of an apathetic state can be observed. This paper describes case a patient traumatic brain lobe presenting depressive syndrome associated symptoms. After appropriate treatment for depression, intense apathy was revealed, irreversible sequelae injury, constituting...
Infection of the human central nervous system (CNS) by larvae Taenia solium, termed neurocysticercosis (NCC), is endemic in most developing countries, where it a major cause acquired seizures and other neurological morbidity, including neuropsychiatric symptoms. However, despite its frequent manifestation, some findings, such as cognitive impairment dementia, remain poorly understood. Less commonly, NCC may affect ventricular subarachnoid spaces this form known extraparenchymal...
Alexia with agraphia is defined as an acquired impairment affecting reading and writing ability. It can be associated aphasia, but also occur isolated entity. This has classically been a left angular gyrus lesion In the present study, we describe case involving patient who developed alexia other cognitive deficits after thalamic hemorrhage. addition, discuss potential mechanisms of this <em>cortical</em> dysfunction syndrome caused by subcortical injury. We examined presented due...
Background The purpose of this study was to determine whether whole-body MRI (WBMRI) with diffusion-weighted sequences, which is free ionizing radiation, can perform as well traditional methods when used alone for staging or follow-up pediatric cancer patients. Methods After obtaining approval from our institutional research ethics committee and appropriate informed consent, we performed 34 examinations in 32 were anonymized analyzed by two radiologists at least 10 years' experience. Results...
Abstract Changes in hippocampal subfield volumes (HSV) along the Alzheimer's disease (AD) continuum have been scarcely investigated to date elderly subjects classified based on presence of β‐amyloid aggregation and signs neurodegeneration. We patients (either sex) with mild dementia compatible AD ( n = 35) or amnestic cognitive impairment 39), cognitively unimpaired sex; 26) using [ 11 C]PIB‐PET assess (A+) 18 F]FDG‐PET account for neurodegeneration ((N)+). Magnetic resonance imaging‐based...
ABSTRACT Acquired hepatocerebral degeneration is an underdiagnosed neurologic syndrome characterized by parkinsonism, ataxia or other movement disorders and neuropsychiatric cognitive symptoms. It occurs in patients with chronic liver disease, especially those who develop portosystemic shunting often unrecognized as a cause of decline. Recently, its pathogenesis has been associated manganese accumulation basal ganglia some treatments proposed. The aim this article was to report case discuss...
Background: Studies of elderly subjects using biomarkers that are proxies for Alzheimer’s disease (AD) pathology have the potential to document meaningful relationships between cognitive performance and biomarker changes along AD continuum. Objective: To differences across distinct stages a categorization based on presence PET-assessed amyloid-β (Aβ) burden neurodegeneration. Methods: Patients with mild dementia compatible (n = 38) or amnestic impairment (aMCI; n 43) cognitively unimpaired...
ABSTRACT Deep brain stimulation (DBS) has been widely used to control motor symptoms and improve quality of life in patients with Parkinsons disease (PD). Recently, DBS the subthalamic nucleus (STN) become preferred target for mixed symptoms. Despite resultant improvements, procedure associated cognitive decline, mainly language skills, also psychiatric Objective: To evaluate influence STN on cognition, mood life. Methods: We studied 20 PD submitted from May 2008 June 2012 an extensive...
The Ross syndrome was first described in 19581, as a degenerative autonomic nervous system disorder defined by the triad: widespread anhidrosis, diminished deep tendon reflexes, and Adie’ tonic pupils1,2. most disturbing symptoms are segmental compensatory hyperhidrosis heat intolerance. This article reports 44-year-old male with 19-year history of progressive anhidrosis intolerance, mainly complaint. A patch hiperhidrosis present lower abdominal T11-12 dermatomes […] Anhidrosis sign [...]
A 62-year-old previously cognitively intact man presented to the emergency department with acute impairment of anterograde memory (ability form new memories).1 Head CT did not show changes; however, amnesia persisted. MRI disclosed an infarct in left posterior hippocampus and a nonacute lacunar stroke right anterior thalamus (figure). Memory testing showed severe deficits verbal visual memory, persisting after 2 months. Bilateral lesions located anywhere Papez circuit (hippocampal...