A5101879757- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Stroke Rehabilitation and Recovery
- Spatial Neglect and Hemispheric Dysfunction
- Cancer-related cognitive impairment studies
- Ovarian cancer diagnosis and treatment
- Cognitive Functions and Memory
- Neurological Disorders and Treatments
- Glioma Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- Long-Term Effects of COVID-19
- Health, Education, and Aging
- Epilepsy research and treatment
- Language Development and Disorders
- Alzheimer's disease research and treatments
- Psychology and Mental Health
- Physical Education and Gymnastics
- Attention Deficit Hyperactivity Disorder
- Educational and Psychological Assessments
- Health and Well-being Studies
- Autism Spectrum Disorder Research
- Traumatic Brain Injury Research
Universidade de São Paulo
2015-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2005-2023
University of Ferrara
2008-2015
Arcispedale Sant'Anna
2015
Universidade Brasil
2004-2008
Universidade Federal do Rio de Janeiro
2008
Universidad de Londres
2008
University College London
2002
National Hospital for Neurology and Neurosurgery
2002
Czech Academy of Sciences, Institute of Psychology
1996
Abstract Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, Consortium on Dementia (LAC‐CD) proposes an agenda for integration to deliver Knowledge Action Framework (KtAF). First, we summarize evidence‐based strategies (epidemiology,...
Traumatic brain injury (TBI) is one of the most frequent causes damage. Cognitive deficits reported in literature after moderate to severe TBI include memory, language, executive functions, attention and information processing speed impairments. However, systematic studies on patients with mild are scarce although neuropsychological changes present. OBJECTIVE: To investigate cognitive functioning TBI. METHOD: We evaluated 12 using a comprehensive protocol (PN01) tests. RESULTS: There were...
To present the development of an adapted version Boston Naming Test for Portuguese speakers, and to investigate effects age, education gender on both original in respect Brazilian speakers.Eighty items, including 60 ones 20 items were administered 739 healthy subjects aged between 6 77 years who received 0 17 education.The coefficients General Linear Model estimation suggested that age statistically significant predict total scores. In addition, score variances, justified by such predictors,...
Abstract Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported survey to explore the ongoing work, needs, interests, potential barriers, opportunities for future studies related biomarkers. The results show that neuroimaging is most used biomarker (73%), followed by genetic (40%), peripheral fluids (31%), cerebrospinal fluid (29%). Regarding barriers LAC, lack of funding appears undermine implementation clinical...
In this study, the effectiveness of a group-based attention and problem solving (APS) treatment approach to executive impairments in patients with frontal lobe lesions was investigated. Thirty participants lobes, 16 left (LF) 14 right (RF) lesions, were allocated into three groups, each 10 participants. The APS initially compared two other control conditions, an information/education (IE) treatment-as-usual or traditional rehabilitation (TR), groups subsequently receiving intervention...
The relationship between brain tumors and cognitive deficits is well established in the literature. However, studies investigating status low high-grade gliomas patients are scarce, particularly with average or lower educational level. This study aimed at functioning a sample of before surgical intervention.The low-grade (G1, n=19) glioma (G2, n=8) underwent detailed neuropsychological assessment memory, executive functions, visuo-perceptive visuo-spatial abilities, intellectual level...
The prefrontal cortex (PFC) has been implicated in the ability to apply semantic organizational strategies during verbal encoding and episodic learning. However, there no direct evidence demonstrating which specific areas PFC are engaged after cognitive training using healthy adult human subjects. In this study, we investigated effects of strategic on brain activity changes behavioral performance, training, functional MRI (fMRI). There was a significant activation bilateral dorsolateral...
Patients with Alzheimer's disease (AD) gradually lose their cognitive competence, particularly memory, and the ability to perform daily life tasks. Neuropsychological rehabilitation is used improve functions by facilitating memory performance through use of external aids internal strategies. The effect neuropsychological training - motor movements, verbal association, categorization activities living (ADL) was tested in a sample 5 elderly out-patients (mean age: 77.4 ± 2.88 years), mild AD...
Abstract The CpG island methylator phenotype (CIMP) in colorectal tumours can be recognized by an increased frequency of aberrant methylation a specific set genomic loci. Because the strong association CIMP with high microsatellite instability (MSI‐H), identification CIMP+ within stable (MSS) cancers may not straightforward. To overcome this potential limitation, we have built improved seven‐locus markers that includes CACNA1G, IGF2, RUNX3, HTR6, RIZ1, MINT31, and MAP1B. This new revealed...
The corpus callosum is the largest fiber bundle in central nervous system and it takes part several cognitive pathways. It can be affected by multiple sclerosis (MS) early disease. DTI capable of infering microstructural organization white matter. vectorial analysis offers more specific indices axial diffusivity (AD) radial (RD), which have shown to useful discriminate myelin damage from axon loss, respectively. This study presents results (mean (MD), fractional anisotropy (FA), RD, AD) 23...
In this study we examined differences in fMRI activation and deactivation patterns during episodic verbal memory encoding between individuals with MCI (n=18) healthy controls (n=17). Participants were scanned two different sessions the application of self-initiated or directed instructions to apply semantic strategies at word lists. participants showed reduced free recall scores when using that increased baseline controls' level after provided. During strategic encoding, greater recruitment...
Patients with low-grade glioma (LGG) have been studied as a model of functional brain reorganization due to their slow-growing nature. However, there is no information regarding which areas are involved during verbal memory encoding after extensive left frontal LGG resection. In addition, it remains unknown whether these patients can improve performance instructions apply efficient strategies. The neural correlates were investigated in who had undergone lobe (LFL) resections and healthy...
ABSTRACT Background: The aims of this study were (1) to describe and compare the performance illiterate low-educated older adults, without evidence cognitive impairment, on different versions Boston Naming Test (BNT) original, Brazilian adapted, abbreviated 30-item (even odd) 15-item from CERAD (Consortium Establish a Registry for Alzheimer's Disease) battery; (2) original versus adapted BNT. Methods: A total 180 healthy adults (60 years or older) stratified according educational level (0,...
The present study aims to evaluate psychometric data on the population of Brazil using Color Trails Test (CTT).The instrument was applied 1,942 subjects who came from north (1.4%), northeast (10.4%), midwest (7.7%), southeast (65.9%), and south (13.9%) regions Brazil.Ages varied 18 86 years (M = 40.03years; DP 16.02), with 386 males (19.9%) 1,556 females (80.1%).Regarding schooling, 57 (3%) participants were illiterate, 1.240 (64%) had primary education 645 (33%) a high school and/or...
Background: The activity of matrix metalloproteinase-9 (MMP-9) depends on two isoforms, an 82 kDa active MMP-9 modulated by its specific tissue inhibitor (TIMP-1), and a 65 TIMP-1 resistant MMP-9. relevance these enzymatic isoforms in multiple sclerosis (MS) is still unknown. Objective: To investigate the contribution to MS pathogenesis. Methods: We measured serum levels assay systems 86 relapsing–remitting (RRMS) patients, categorized according clinical magnetic resonance imaging (MRI)...
Executive functions (EFs) regulate human behavior and allow individuals to interact act in the world. EFs are sensitive sociodemographic variables such as age, which promotes their decline, others that can exert a neuroprotective effect.To assess predictive role of education, occupation family income on decline executive among sample with wide age range.A total 925 participants aged 18-89 years 1-28 years' education were submitted assessment using Card Sorting Test (CST), Phonemic Verbal...
Twenty-one patients with unilateral frontal neurosurgical lesions (11 left and 10 right) 38 temporal lobectomies (19 19 were compared to 44 normal control subjects in their performance on a computerised version of the Tower Hanoi (TOH) test. In order explore effect selection equivocation performance, two types problems administered, determined by whetherthe mainroutes achieve goal weresimilar or dissimilar length. To effectof working memory load, task was administered that required subject...