A5003868622- TGF-β signaling in diseases
- Mast cells and histamine
- Metabolism, Diabetes, and Cancer
- Liver physiology and pathology
- Pancreatic function and diabetes
- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Protein Kinase Regulation and GTPase Signaling
- 3D Printing in Biomedical Research
- Receptor Mechanisms and Signaling
- Drug-Induced Hepatotoxicity and Protection
- Hippo pathway signaling and YAP/TAZ
- Genomics, phytochemicals, and oxidative stress
- Pancreatic and Hepatic Oncology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Sphingolipid Metabolism and Signaling
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Liver Disease and Transplantation
Universidad Nacional Autónoma de México
2015-2024
Instituto Nacional de Cardiología
1991-2024
Universidad Autónoma de la Ciudad de México
2020-2023
In-Q-Tel
2011
University of Pennsylvania
2002
University of Toronto
1999-2000
Hospital for Sick Children
1996-2000
SickKids Foundation
1999-2000
Center for Research and Advanced Studies of the National Polytechnic Institute
1995
Mothers against Dpp-related or Smad proteins are essential components of serine/threonine kinase receptor signaling pathways that regulated by phosphorylation. Recently, it was demonstrated Smad2 interacts transiently with and is a direct substrate the transforming growth factor-β (TGF-β) type I receptor, TβRI. Phosphorylation sites on were localized to carboxyl-terminal fragment containing three serine residues at positions 464, 465, 467. In this report, we show TβRI specifically...
BMP7 and activin are members of the transforming growth factor β superfamily. Here we characterize endogenous signaling pathways in P19 embryonic carcinoma cells. We show that bind to same type II receptors, ActRII IIB, but recruit distinct I receptors into heteromeric receptor complexes. The major observed was ALK2, while bound exclusively ALK4 (ActRIB). elicited biological responses activated different Smad pathways. stimulated phosphorylation Smad1 5, formation complexes with Smad4...
Control analysis of the glycolytic flux was carried out in two fast‐growth tumor cell types human and rodent origin (HeLa AS‐30D, respectively). Determination maximal velocity ( V max ) 10 enzymes from hexokinase to lactate dehydrogenase revealed that (153–306 times) phosphfructokinase‐1 (PFK‐1) (22–56 had higher over‐expression rat AS‐30D hepatoma cells than normal freshly isolated hepatocytes. Moreover, steady‐state concentrations metabolites, particularly those products PFK‐1, were...
Abstract The transforming growth factor-β (TGF-β) family plays major pleiotropic roles by regulating many physiological processes in development and tissue homeostasis. TGF-β signaling pathway outcome relies on the control of spatial temporal expression >500 genes, which depend functions Smad protein along with those diverse modulators this pathway, such as transcriptional factors cofactors. Ski (Sloan-Kettering Institute) SnoN (Ski novel) are Smad-interacting proteins that negatively...
The presence of cancer stem cells (CSCs) has been associated with the induction drug resistance and disease recurrence after therapy. 5-Fluorouracil (5FU) is widely used as first-line treatment colorectal (CRC). However, its effectiveness may be limited by in tumor cells. Wnt pathway plays a key role development CRC progression, but it not clearly established how involved CSCs to treatment. This work aimed investigate played canonical Wnt/β-catenin 5FU Using spheroids model enrichment cell...
Surface modification of polydimethylsiloxane (PDMS) for organ-on-a-chip (OOC) systems is fundamental the success cell physiological assays. Although UV light commonly used this purpose, surface chemical modifications are only temporary. To overcome these limitations, an alternative approach proposed: a physicochemical using ozone and heterofunctional crosslinker sulfo-SANPAH (SS). This simple one-step carried out on PDMS microchannels OOC platforms. A broad characterization based...
Smad7 is an inhibitory Smad protein that blocks Transforming Growth Factor-beta (TGF-β) signaling through a negative feedback loop, also capable of mediating the crosstalk between TGF-β and other pathways. mRNA levels are upregulated after signaling; subsequently, binds type I receptor blocking R-Smad phosphorylation eventually signaling. Because this function, can antagonize diverse cellular processes regulated by such as cell proliferation, differentiation, apoptosis, adhesion migration....
Smad7 is an inhibitory Smad protein that blocks Transforming Growth Factor-beta (TGF-β) signaling through a negative feedback loop, also capable of mediating the crosstalk between TGF-β and other pathways. mRNA levels are upregulated after signaling; subsequently, binds type I receptor blocking R-Smad phosphorylation eventually signaling. Because this function, can antagonize diverse cellular processes regulated by such as cell proliferation, differentiation, apoptosis, adhesion migration....
The human SKI-like (<i>SKIL</i>) gene encodes the SMAD transcriptional corepressor SNON that antagonizes TGF-β signaling. protein levels are tightly regulated by pathway: whereas a short stimulation with decreases its degradation via proteasome, longer treatment increases inducing <i>SKIL</i> expression. Here, we investigated molecular mechanisms involved in self-regulation of expression SNON. Bioinformatics analysis showed proximal promoter contains response element (TRE) bearing four...
Under physiological conditions, cells produce low basal levels of reactive oxygen species (ROS); however, in pathologic conditions ROS production increases dramatically, generating high concentrations toxic unsaturated aldehydes. Aldehyde dehydrogenases (ALDHs) are responsible for detoxification these aldehydes protecting the cell. Due to relevance enzymes, it is important design strategies modulate their activity. It was previously reported that omeprazole activation ALDH1A1 protected...
Interferon-gamma (IFN-γ) plays a dual role in cancer; it is both pro- and an antitumorigenic cytokine, depending on the type of cancer. The deregulation IFN-γ canonic pathway associated with several disorders, including vulnerability to viral infections, inflammation, cancer progression. In particular, interplay between lung adenocarcinoma (LUAD) infections appears exist association signaling. this mini-review, we investigated status signaling expression level its components LUAD....
Protein kinase A (PKA) regulates morphogenetic responses to bone proteins (BMPs) during embryogenesis. However, the mechanisms by which PKA BMP function are unknown. During kidney development, BMP-2 and high doses of BMP-7 inhibit branching morphogenesis, whereas low stimulatory (Piscione, T. D., Yager, Gupta, I. R., Grinfeld, B., Pei, Y., Attisano, L., Wrana, J. Rosenblum, N. D. (1997) <i>Am. Physiol.</i> 273, F961–F975). We examined interactions between these BMPs in embryonic explants...