A5062014058- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Natural Compounds in Disease Treatment
- Neurogenesis and neuroplasticity mechanisms
- Liver Disease Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Nuclear Receptors and Signaling
- Service-Learning and Community Engagement
- Cancer-related Molecular Pathways
- Liver physiology and pathology
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Carcinogens and Genotoxicity Assessment
- Liver Disease and Transplantation
- Natural Compound Pharmacology Studies
- Genomics, phytochemicals, and oxidative stress
- Education and Critical Thinking Development
- Metal complexes synthesis and properties
Instituto Nacional de Neurología y Neurocirugía
2016-2025
The University of Texas Rio Grande Valley
2022
Ibero American University
2013
Universidad Nacional Autónoma de México
2001-2011
Epidemiological studies suggest that including fruits, vegetables, and whole grains in regular dietary intake might prevent reverse cellular carcinogenesis, reducing the incidence of primary tumours. Bioactive components present food can simultaneously modulate more than one carcinogenic process, cancer metabolism, hormonal balance, transcriptional activity, cell-cycle control, apoptosis, inflammation, angiogenesis metastasis. Some have shown an inverse correlation between a diet rich...
Glioblastoma multiforme (GBM) is the most aggressive of primary brain tumors, with a grim prognosis despite intensive treatment. In past decades, progress in research has not significantly increased overall survival rate.The vitro antineoplastic effect and mechanism action Casiopeina III-ia (Cas III-ia), copper compound, on rat malignant glioma C6 cells was investigated.Cas inhibited cell proliferation, inducing autophagy apoptosis, which correlated formation autophagic vacuoles,...
The metabolic reprogramming that promotes tumorigenesis in glioblastoma is induced by dynamic alterations the hypoxic tumor microenvironment, as well transcriptional and signaling networks, which result changes global genetic expression. pathways PI3K/AKT/mTOR RAS/RAF/MEK/ERK stimulate cell metabolism, either directly or indirectly, modulating factors p53, HIF1, c-Myc. overexpression of HIF1 c-Myc, master regulators cellular a key contributor to synthesis bioenergetic molecules mediate...
In this work, we investigated the effects of Casiopeina Il-gly (Cas ILgly)—a new copper compound exhibiting antineoplastic activity—on glioma C6 cells under both in vitro and vivo conditions, as an approach to identify potential therapeutic agents against malignant glioma. The exposure Cas Ilgly significantly inhibited cell proliferation, increased reactive oxygen species (ROS) formation, induced apoptosis a dose-dependent manner. cultured cells, caused mitochondrio-nuclear translocation...
Cirrhosis is one of the most common causes mortality worldwide, because hepatic dysfunction constitutes a potentially lethal condition. Having demonstrated hepatoprotective effect adenosine against CCl 4 -induced cirrhosis, present study was aimed at assessing adenosine's on an already-established micronodular cirrhosis. Chronic administration (10 weeks) induced cirrhotic state, characterized by increased liver fibronectin and collagen types I III content, enhanced expression α-1 (I) mRNA,...
Glioma cells exhibit genetic and metabolic alterations that affect the deregulation of several cellular signal transduction pathways, including those related to glucose metabolism. Moreover, oncogenic signaling pathways induce expression genes, increasing enzyme activities thus critical biosynthetic generate nucleotides, amino acids, fatty which provide energy intermediates are essential accomplish needs glioma cells. In this review, we aim explore how dysregulated enzymes their metabolites...
J Oral Pathol Med (2010) 39: 709–714 Excessive fluoride ingestion has been identified as a risk factor for fluorosis and oxidative stress. The stress results from the loss of equilibrium between antioxidative mechanisms that can produce kinase activation, mitochondrial disturbance DNA fragmentation, resulting in apoptosis. Actually many people are exposed to no-adverted consumption acute or chronic way. aim this study was determine effect sodium on first molar germ relation its enzymes...
Abstract Background Reactive oxygen species (ROS) are important mediators in a number of degenerative diseases. Oxidative stress refers to the imbalance between production ROS and ability scavenge these through endogenous antioxidant systems. Since antioxidants can inhibit oxidative processes, it becomes relevant describe natural compounds with properties which may be designed as therapies decrease damage stimulate cytoprotective The present study tested protective effect two xanthones...
Epilepsy is one of the most common neurological disorders in humans, and role cerebellum its physiopathology remains subject study. The Purkinje cells (PC), whose axons target dentate interpositus nuclei, form main cerebellar output to forebrain structures involved epilepsy. Cerebellar atrophy related loss PC has been reported chronic epilepsy although mechanism unclear. Taking into account that an overexpression β-Catenin with cell death, here we present signaling type death rats seizures...
Ginkgo biloba extracts have long been used in Chinese traditional medicine for hundreds of years. The most significant extract obtained from leaves has EGb 761, a widely phytopharmaceutical product Europe. 761 is well-defined mixture active compounds, which contains two main substances: flavonoid glycosides (24–26%) and terpene lactones (6–8%). These compounds shown antiapoptotic effects through the protection mitochondrial membrane integrity, inhibition cytochrome c release, enhancement...
We have proposed that controlled peroxidative modifications of membranes could be playing a role in the early steps liver regeneration. Hence, lipid peroxidation (LP) was modified vivo by treatment with vitamin E rats subjected to partial hepatectomy (PH), and its influence on regeneration evaluated. Our results, using several methods monitor LP, indicate administration promoted decreased LP rate subcellular membranes. Vitamin drastically diminished cytosolic shifting earlier increased...
Abstract Quinolinate (QUIN) neurotoxicity has been attributed to degenerative events in nerve tissue produced by sustained activation of N ‐methyl‐ D ‐aspartate receptor (NMDAr) and oxidative stress. We have recently described the protective effects that selenium (Se), an antioxidant, produces on different markers QUIN‐induced (Santamaría et al., 2003, J Neurochem 86:479–488.). However, mechanisms which Se exerts its actions remain unclear. Since some these are thought be related with...
Although it has mainly been described qualitatively, whole brain irradiation induces somnolence in patients with malignant diseases. Therefore, we used a rat model to quantify the effects of healthy tissue on both sleep-wake patterns and expression pro-inflammatory cytokine interleukin-1β (IL-1β), which is known induce sleep.Different groups were examined at three time points after (1 day, 30 days 60 days). Polysomnographic recordings performed each before total cranial (12 Gy). IL-1β...