A5040888441- Ion channel regulation and function
- Asthma and respiratory diseases
- Ion Channels and Receptors
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Adenosine and Purinergic Signaling
- Hormonal and reproductive studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Stress Responses and Cortisol
- Medical Imaging and Pathology Studies
- Pharmacological Effects and Assays
- Cardiac electrophysiology and arrhythmias
- Neonatal Respiratory Health Research
- Parasitic Infections and Diagnostics
- Ion Transport and Channel Regulation
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Amoebic Infections and Treatments
- Estrogen and related hormone effects
- Computational Drug Discovery Methods
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
- Respiratory and Cough-Related Research
Universidad Nacional Autónoma de México
2015-2024
Instituto Nacional de Enfermedades Respiratorias
2003-2009
University of Alberta
2009
Instituto Nacional de Perinatología
2009
Universidad Autónoma de la Ciudad de México
2005
Changes in the androgen levels asthmatic men may be associated with severity of asthma. Androgens induce a nongenomic relaxation airway smooth muscle, but underlying mechanisms remain unclear. The aim this study was to investigate potential bronchorelaxing action testosterone (TES) and its metabolites (5α- 5β-dihydrotestosterone (DHT). A preventive effect on ovalbumin (OVA)-induced bronchospasm observed sensitized guinea pigs for each androgen. were studied response bronchoconstrictors:...
Prolactin (PRL) is a peptidic hormone that displays pleiotropic functions in the organism including different actions brain. PRL exerts neuroprotective effect against excitotoxicity produced by glutamate (Glu) or kainic acid both vitro and vivo models. It well known Glu causes cell death through apoptotic necrotic pathways due to intracellular calcium ([Ca2+] i) overload. Therefore, aim of present study was assess molecular mechanisms which maintains cellular viability primary cultures rat...
Idiopathic pulmonary fibrosis (IPF) is an age-related, progressive and lethal disease, whose pathogenesis associated with fibroblasts/myofibroblasts foci that produce excessive extracellular matrix accumulation in lung parenchyma. Hypoxia has been described as a determinant factor its development progression. However, the role of distinct members this pathway not completely described.By western blot, quantitative PCR, Immunohistochemistry Immunocitochemistry were evaluated, expression HIF...
Androgen vasorelaxing action is a subject of recent interest. We investigated the involvement l-type voltage-operated Ca2+ channels (L-VOCCs), K+ channels, intracellular concentration ([Ca2+]i), and cAMP in effect testosterone 5β-dihydrotestosterone (5β-DHT) on rat thoracic aorta. Isolated aortic rings were used to study potency 5β-DHT KCl- noradrenaline-induced contractions. Patch-clamp was analyze androgen effects inward outward currents. The fluorescence technique evaluate [Ca2+]i single...
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by increased activation of fibroblasts/myofibroblasts. Previous reports have shown that IPF fibroblasts are resistant to apoptosis, but the mechanisms remain unclear. Since inhibition mitochondrial permeability transition pore (mPTP) has been implicated in resistance this study, we analyzed role function and mPTP on apoptosis under basal conditions after mitomycin C-induced apoptosis. We measured release cytochrome c,...
: Schizophrenia (SZ) is a multifactorial chronic psychiatric disorder with worldwide prevalence of 1%. Altered expression PLCβ occurs in SZ patients, suggesting alterations the PLCβ/IP
Airway hyperresponsiveness is a key feature of asthma, but its mechanisms remain poorly understood. Leukotriene D(4) (LTD(4)) one the few molecules capable producing airway hyperresponsiveness. In this study, LTD(4), not leukotriene C(4) (LTC(4)), produced leftward displacement concentration-response curve to histamine in bovine smooth muscle strips. Neither LTC(4) nor LTD(4) modified carbachol. simultaneous measurements intracellular Ca(2+) ([Ca(2+)](i)) and contraction, or carbachol...
Some receptors and signaling molecules, such as Rho-kinase (ROCK), localize in caveolae. We asked whether the function of histamine (H 1 ) 5-hydroxytryptamine (serotonin) (5-HT 2A bovine tracheal smooth muscle are modified after caveolae disruption if so, altered ROCK activity plays a role this modification. Methyl-β-cyclodextrin (MβCD), used to deplete membrane cholesterol, was shown disrupt diminish sustained contractions (∼80%), 5-HT (100%), α-methyl-5-HT KCl (∼30%). Cholesterol-loaded...
Abstract Background Nucleotides released to the extracellular space stimulate purinergic receptors, and their effects are modulated by ectonucleotidases. The role of ATP in allergic bronchospasm has been scantly studied. Methods We used several techniques (plethysmography, organ baths, confocal microscopy, RT ‐ PCR , measurement) explore nucleotides ectonucleotidases guinea pigs. Results While allergenic challenge with a low‐dose ovalbumin (OVA) only produced small (~2‐fold basal lung...