A5062274590- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Biochemical Analysis and Sensing Techniques
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Photoreceptor and optogenetics research
- Biochemical effects in animals
- Neurobiology and Insect Physiology Research
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
- Hereditary Neurological Disorders
- Immune Response and Inflammation
- Ion Channels and Receptors
- Nerve injury and regeneration
- RNA Research and Splicing
- Neurological Disease Mechanisms and Treatments
- Immune cells in cancer
- Medicinal Plants and Bioactive Compounds
- Treatment of Major Depression
- Pediatric health and respiratory diseases
Instituto Nacional de Psiquiatría
2016-2025
Universidad Nacional Autónoma de México
2014
Schizophrenia (SZ) is a chronic disabling mental disorder with high heritability, and several immune-regulating genes have been implicated in its pathophysiology In this study, we investigated the expression of Toll-like receptors (TLRs) 1, 2, 6 peripheral blood monocytes from SZ patients healthy control subjects (HCSs) Mexican population, focusing on specific SZ-associated gene variants. Gene expressions were assessed by qPCR, protein was measured using flow cytometry. The secretory...
Melatonin (MEL), the main product synthesized by pineal gland, stimulates early and late stages of neurodevelopment in adult brain. MEL increases dendrite length, thickness complexity hilar mossy neurons hippocampus. Dendrite formation involves activation Ca2+/Calmodulin (CaM)-dependent kinase II (CaMKII) CaM. Previous work showed that increased synthesis translocation CaM, suggesting activates CaM-dependent enzymes this pathway. In we investigated whether CaMKII organotypic cultures from...
Abstract Dim light exposure of the mother during pregnancy has been proposed as one environmental factors that affect fetal brain development in schizophrenia. Melatonin circulating levels are regulated by light/dark cycle. This hormone stimulates neuronal differentiation adult brain. However, little is known about its role human development. Olfactory precursors ( ONP s) useful for studying physiopathology neuropsychiatric diseases because they mimic all stages neurodevelopment culture....
Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony environmental light/dark cycle. A gradual increase circulating levels of melatonin occur after lights off, reaching its maximum around middle dark phase. Agonists receptors have proved effectiveness as antidepressants clinical trials. However, there contradictory evidence about potential antidepressant effect itself. Herein we studied administration mice at two zeitgeber times (ZT; ZT = 0 on; 12:12 L/D), one...
Major depressive disorder is a disabling disease with the number of affected individuals increasing each year. Current antidepressant treatments take between three to six weeks be effective forty percent patients being resistant treatment, making it necessary search for new treatments. Ketamine, phencyclidine hydrochloride derivative, given intravenously, induces rapid effect in humans. In mice, causes increased neurogenesis and antidepressant-like effects. However, also produces...
Abstract Second generation antipsychotics ( SGA ) are associated with adverse cardiometabolic side effects contributing to premature mortality in patients. While mechanisms mediating these remain poorly understood, three independent studies recently demonstrated that melatonin was protective against risk ‐treated As one of the main target areas circulating brain is suprachiasmatic nucleus SCN ), we hypothesized involved ‐induced early cardiovascular Wistar rats. We evaluated acute olanzapine...
: Schizophrenia (SZ) is a multifactorial chronic psychiatric disorder with worldwide prevalence of 1%. Altered expression PLCβ occurs in SZ patients, suggesting alterations the PLCβ/IP
The pro-oxidant compound okadaic acid (OKA) mimics alterations found in Alzheimer’s disease (AD) as oxidative stress and tau hyperphosphorylation, leading to neurodegeneration cognitive decline. Although loss of dendrite complexity occurs AD, the study this post-synaptic domain chemical-induced models remains unexplored. Moreover, there is a growing expectation for therapeutic adjuvants counteract these brain dysfunctions. Melatonin, free-radical scavenger, inhibits modulates phosphatases,...
The alterations that underlie the pathophysiology of schizophrenia (SCZ) include dysregulation structural and functional properties neurons. Among these, secretion neurotransmitters hormones, which plays a key role for neuronal communication development, is altered. Neuronal precursors from human olfactory epithelium have been recently characterized as reliable model studying etiopathogenesis neuropsychiatric diseases. Our previous work has shown melatonin enhances development morphological...
The light–dark cycle is an environmental factor that influences immune physiology, and so, variations of the photoperiod length result in altered responsivity. Macrophage physiology comprises a spectrum functions goes from host defense to down-regulation, addition their homeostatic activities. Macrophages also play key role transition innate adaptive responses. Met-enkephalin (MEnk) has been recognized as modulator macrophage acting autocrine or paracrine fashion influence activation,...
In adulthood, differentiation of precursor cells into neurons continues in several brain structures as well the olfactory neuroepithelium. Isolated precursors allow study neurodevelopmental process vitro. The aim this work was to determine whether expression functional Voltage-Activated Ca2+ Channels (VACC) is dependent on stage neuronal obtained from human epithelium a single healthy donor. presence channel-forming proteins Olfactory Sensory Neurons (OSN) demonstrated by immunofluorescent...
Extracellular ATP and trophic factors released by exocytosis modulate in vivo proliferation, migration, differentiation multipotent stem cells (MpSC); however, the purinoceptors mediating this signaling remain uncharacterized derived from human olfactory epithelium (hOE). Our aim was to determine purinergic pathway isolated neuronal precursor (hONPC) that exhibit MpSC features. Cloning limiting dilution a hOE heterogeneous primary culture performed obtain predominantly constituted hONPC....
Las demencias son enfermedades neuropsiquiátricas, progresivas, neurodegenerativas y con una alta prevalencia a nivel mundial. Ocupan uno de los primeros lugares como que causan incapacidad en adultos mayores. En estos pacientes el Sistema Nervioso Central presenta alteraciones anatómico-estructurales celular subcelular se asocian deficiencias cognitivas. particular, la enfermedad Alzheimer han caracterizado marcadores histopatológicos las placas amiloides marañas neurofibrilares. Se sabe...