A5031351532- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Medicinal Plants and Neuroprotection
- Neuroscience and Neuropharmacology Research
- Alkaloids: synthesis and pharmacology
- Photoreceptor and optogenetics research
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Medicinal Plant Extracts Effects
- Phytochemistry and Biological Activities
- Cyclopropane Reaction Mechanisms
- Seed and Plant Biochemistry
- Dermatology and Skin Diseases
- Complementary and Alternative Medicine Studies
- Synthesis and Reactivity of Heterocycles
- Plant Toxicity and Pharmacological Properties
- Plant chemical constituents analysis
- Phytochemicals and Antioxidant Activities
- Treatment of Major Depression
- Memory and Neural Mechanisms
- Herbal Medicine Research Studies
- Piperaceae Chemical and Biological Studies
- Sexual function and dysfunction studies
- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
Instituto Nacional de Psiquiatría
2014-2024
We evaluated the antidepressant-like effect of kaempferitrin (Km) isolated from plant Justicia spicigera (Asteraceae), which is used in traditional medicine for relieving emotional disorders, such as "la tristeza" (sadness or dysthymia) and "el humor" (mood changes). The actions Km were a forced swimming test (FST) suspension tail (TST) mice. explored involvement serotonergic system hypothalamic-hypophysis-adrenal axis (HPA) Km. To evaluate nonspecific effects on general activity, open field...
Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony environmental light/dark cycle. A gradual increase circulating levels of melatonin occur after lights off, reaching its maximum around middle dark phase. Agonists receptors have proved effectiveness as antidepressants clinical trials. However, there contradictory evidence about potential antidepressant effect itself. Herein we studied administration mice at two zeitgeber times (ZT; ZT = 0 on; 12:12 L/D), one...
Neoponcirin causes anxiolytic-like effects in mice when administered intraperitoneally but not orally. is non-water-soluble and insoluble solvents, medium acid, it isomerizes, reducing its bioavailability. To improve the pharmacological properties of neoponcirin, we formed a neoponcirin complex with beta-cyclodextrin (NEO/βCD), which was characterized by FT-IR, UV-Vis, NMR, their solubility profile. We evaluated antidepressant-like NEO/βCD acutely to orally behavioral paradigms, tail...
Citrus paradisi species belong to the Rutaceae family, and it is commonly known as grapefruit. Grapefruit consumption involves a large amount of waste that goes landfills produces significant pollution affecting human health. To examine this phenomenon, we designed an efficient chemical method recovers naringin-rich flavonoid extracts from fresh grapefruits, by using solvent impregnation resin (SIR) with XAD-4 amberlite either methanol or water elution systems. Additionally, focused on...
This study evaluated the antidepressant-like effects of a methanol extract Leonotis nepetifolia in behavioural tests mice. Our results showed that single administration significantly reduced immobility behaviour tail suspension test, while three administrations were necessary to diminish forced swimming test. A daily dose for 28 days improved body weight gain and corticosterone levels mice exposed chronic unpredictable mild stress. Metabolic profiling revealed nepetaefolin,...
This study was aimed to synthesize novel 2-(2-bromophenyl)-N-phenethylacetamides and benzylisoquinoline (BIQ) derivatives be evaluated as antidepressant-like agents in mice. The phenethylacetamides were synthesized by coupling aromatic amides the backbone of 2-bromophenylacetyl chloride. synthesis BIQ achieved reaction between 2-chloropyridine. structures compounds established mainly 1D 2D NMR spectra. Those obtained with moderate good yields forced swim test open field paradigms possible...