Beatríz Camarena
A5017363058- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Genetic Associations and Epidemiology
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Eating Disorders and Behaviors
- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Suicide and Self-Harm Studies
- Genetics and Neurodevelopmental Disorders
- Treatment of Major Depression
- Hormonal Regulation and Hypertension
- Functional Brain Connectivity Studies
- Williams Syndrome Research
- Child Nutrition and Feeding Issues
- Mental Health Treatment and Access
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Personality Disorders and Psychopathology
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Psychosomatic Disorders and Their Treatments
Instituto Nacional de Psiquiatría
2016-2025
Brigham and Women's Hospital
2014
Harvard University
2014
Massachusetts General Hospital
2014
Center for Human Genetics
2014
Broad Institute
2014
Hospital Psiquiatrico Infantil Juan N Navarro
2014
University of Chicago
2013
Universidad Autónoma de la Ciudad de México
2012
Institute of Clinical Research
2007
The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify attributable all interrogated variants. We have quantified variance liability disease explained by SNPs for two phenotypically-related neurobehavioral disorders, obsessive-compulsive disorder (OCD) and Tourette Syndrome (TS), using GCTA. Our analysis yielded point estimate 0.58 (se = 0.09, p 5.64e-12) TS, 0.37...
Objective: Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly heritable neurodevelopmental disorders that thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically complex remains elusive. The authors report a combined genome-wide association study (GWAS) OCD. Method: conducted GWAS in 2,723 cases (1,310 with OCD, 834 syndrome, 579 OCD plus syndrome/chronic tics), 5,667 ancestry-matched controls, 290...
Abstract Obsessive-compulsive disorder (OCD) affects ∼1% of the population and exhibits a high SNP-heritability, yet previous genome-wide association studies (GWAS) have provided limited information on genetic etiology underlying biological mechanisms disorder. We conducted GWAS meta-analysis combining 53,660 OCD cases 2,044,417 controls from 28 European-ancestry cohorts revealing 30 independent significant SNPs SNP-based heritability 6.7%. Separate for clinical, biobank, comorbid,...
To explore the association between 75 candidate genes previously reported in subjects with anxiety symptoms (AS) and depressive (DS) a Mexican cohort. The sample included 2012 individuals from Genomic Database for Addiction Research (MxGDAR/Encodat) cohort, 198 showed AS, 266 DS, 66 (ADS), 1482 healthy controls. DI-PAD screening questionnaire was used to evaluate lifetime AS DS. genotyped commercial microarray PsychArray BeadChip. We identified 707 SNPs of associated PLINK's logistic...
Schizophrenia (SZ) is a chronic disabling mental disorder with high heritability, and several immune-regulating genes have been implicated in its pathophysiology In this study, we investigated the expression of Toll-like receptors (TLRs) 1, 2, 6 peripheral blood monocytes from SZ patients healthy control subjects (HCSs) Mexican population, focusing on specific SZ-associated gene variants. Gene expressions were assessed by qPCR, protein was measured using flow cytometry. The secretory...
Obsessive-compulsive disorder (OCD) is a heritable disorder, but no definitive, replicated OCD susceptibility loci have yet been identified by any genome-wide association study (GWAS). Here, we report results from GWAS in the largest case-control sample (N = 14,140 cases and N 562,117 controls) to date. We explored genetic architecture of OCD, including its relationships other psychiatric non-psychiatric phenotypes. In analysis, one SNP associated with at significant level. Subsequent...
Abstract Studies have recently reported a sexually dimorphic association between obsessive‐compulsive disorder (OCD) and polymorphism related with variations in MAO‐A activity. These observations suggest the possibility of gender differences genetic susceptibility for OCD. We thus reexamined MAO‐A/EcoRV sample 122 OCD patients 124 healthy subjects. An excess allele 1 females major depression was confirmed as previously reported. This difference more strongly associated than males total...
The hypothesis implicating the serotonergic system in pathophysiology of obsessive-compulsive disorder (OCD) is supported by therapeutic efficacy selective serotonin reuptake inhibitors (SSRIs). Since SSRIs act on transporter (5-HTT), it has been suggested that 5-HTT gene (SCL6A4) could be a good candidate for OCD. SCL6A4 44-bp insertion/deletion polymorphism its promoter region (5-HTTLPR). Previous studies have revealed an association between OCD and l allele. We analysed 5-HTTLPR...
Pharmacological studies have shown that sumatriptan, a selective ligand of the serotonin 5-HT-1Dβ autoreceptor, modifies obsessive–compulsive disorder (OCD) symptoms. The current study analysed G861C polymorphism gene in sample 72 trios. Genotyping data were using Family-Based Association Test (FBAT). We did not replicate previously reported linkage disequilibrium between G861 variant and OCD. However, quantitative trait analysis, assessing severity OCD symptoms defined as YBOCS score,...
Genes involved in dopamine neurotransmission are interesting candidates to be analyzed schizophrenia and aggressive behavior. Therefore, we the functional polymorphisms of receptor D4 (DRD4) monoamine oxidase A (MAO-A) genes a sample 71 schizophrenic patients assessed with Overt Aggression Scale measure CLUMP analysis DRD4 48-bp repeat-exon III polymorphism showed significant differences between behavior nonaggressive groups (T1 = 18.77, d.f. 6, p 0.0046; T3 6.54, 0.0195). However, promoter...
Given that schizophrenia is a heterogeneous disorder, the analysis of clinical characteristics could help to identify homogeneous phenotypes may be relevance in genetic studies. Linkage and association studies have suggested locus predisposing reside within Xp11. We analyzed uVNTR rs1137070, polymorphisms from MAOA rs1799836 MAOB genes perform single SNP case-control study sample 344 patients 124 control subjects. Single polymorphism uVNTR, rs1137070 SNPs did not show statistical differences...
The efficacy of schizophrenia treatments using antipsychotics (APs) has long been established, but the benefit obtained by several patients conventional APs (typical or atypical) not enough. Currently, genetic study primary mechanisms action focused on dopaminergic pathways. objective this was to determine if response phenotypes (responder, resistance treatment, and ultra-resistance treatment groups) are associated with six single-nucleotide polymorphisms: COMT (Val158Met), DRD2 (A-241G,...
Resumen Introducción. La obesidad es la acumulación excesiva de grasa corporal, lo que condiciona una alta comorbilidad. El consumo descontrolado alimentos hipercalóricos causa su desarrollo; ésta conducta características similares a pacientes con adicción sustancias. escala los alimentos, YFAS (Yale Food Addiction Scale), permite identificar sujetos adictiva alimentos. Objetivo. Validar en español muestra población mexicana adulta. Método. participantes (160) respondió encuesta dos...