A5008148536- Parasitic Infections and Diagnostics
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Amoebic Infections and Treatments
- Phytochemical compounds biological activities
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Sesquiterpenes and Asteraceae Studies
- Ethnobotanical and Medicinal Plants Studies
- Crystallization and Solubility Studies
- Phytochemistry and Biological Activities
- X-ray Diffraction in Crystallography
- Bioactive Compounds and Antitumor Agents
- Psidium guajava Extracts and Applications
- Traditional Chinese Medicine Analysis
- Plant Toxicity and Pharmacological Properties
- Plant chemical constituents analysis
- Plant biochemistry and biosynthesis
- Chemical synthesis and alkaloids
- Clostridium difficile and Clostridium perfringens research
- Moringa oleifera research and applications
- Phytochemistry and Bioactive Compounds
- Parasites and Host Interactions
- Phytochemicals and Antioxidant Activities
- Biological Activity of Diterpenoids and Biflavonoids
Hospital de Especialidades
2015-2025
Centro Medico Nacional Siglo XXI
2015-2025
Mexican Social Security Institute
2015-2025
Instituto Politécnico Nacional
1999-2019
Corporación para Investigaciones Biológicas
2003
Universidad Nacional Autónoma de México
1989-2001
Ethanolic extract obtained from Annona cherimola Miller (EEAc) and the flavonoid rutin (Rut) were evaluated in this study to determine their antihyperglycemic content, % HbA1c reduction, antihyperlipidemic activities. Both treatments separately combination with oral antidiabetic drugs (OADs) acarbose (Aca), metformin (Met), glibenclamide (Gli), canagliflozin (Cana) acute subchronic assays. The evaluation of assay showed that EEAc Rut administered significantly reduce hyperglycemia a manner...
Background/Objectives: Incomptine A (IA) has cytotoxic activity in non-Hodgkin lymphoma (NHL) cancer cell lines. Its effects on U-937 cells include induction of apoptosis, production reactive oxygen species, and inhibition glycolytic enzymes. We examined the altered protein levels present lymph nodes an vivo mouse model. Methods: induced model with Balb/c mice treated it IA or methotrexate, as well healthy mice. determined expressed proteins by TMT based LC-MS/MS method (Data are available...
Pleopeltis crassinervata has demonstrated antimicrobial effects, including anti-Toxoplasma activity, which been attributed to the presence of compounds such as terpenes and fatty acid methyl esters. In this study, effects P. hexane subfraction one (Hsf1) on Toxoplasma gondii tachyzoite ultrastructure were evaluated using TEM SEM, lytic cycle processes adhesion, invasion, proliferation phase-contrast microscopy. Additionally, antioxidant capacity its main (phytol hexadecenoic ester)...
A bioguided fractionation of the hexane extract obtained from Psidium guajava leaves led to isolation sesquiterpenes with depressant activities on central nervous system. The results demonstrated that already reported relaxant properties are largely due presence terpenes, especially caryophyllene-oxide and β-selinene, which were by far largest single components potentiated pentobarbital sleeping time latency convulsions induced leptazol in mice. Calcium concentration-response curves showed a...
Annona cherimola, known as "chirimoya" has been reported in Mexican traditional medicine for the treatment of diabetes.The aims present study were to validate and assess use A. cherimola an antidiabetic agent.The ethanol extract from (300 mg/kg, EEAc), subsequent fractions (100 mg/kg), rutin (30 mg/kg) studied on alloxan-induced type 2 diabetic (AITD) normoglycemic rats. In addition, oral glucose tolerance test (OGTT) sucrose (OSTT) performed Molecular docking technique was used conduct...
The aerial parts of Salvia clinopodioides afforded abietanes 1a, 2a, and 3 (clinopodiolides A–C), two which possess an unusual lactol moiety at C-19–C-20, together with icetexane named clinopodiolide D (4a). Their structures were established by spectroscopic means, mainly 1H 13C NMR, including 1D 2D homo- heteronuclear experiments. antioxidant, antiprotozoal, antidiarrheal effects the isolates evaluated. Compounds 2a showed better than α-tocopherol in inhibition lipid peroxidation IC50 (μM)...
Bioassay-guided fractionation of the antiprotozoal extract Geranium niveum led to isolation two new A-type proanthocyanidins, epi-afzelechin-(4β→8,2β→O→7)-afzelechin (1) and epi-catechin-(4β→8,2β→O→7)-afzelechin (2). Compounds 1 2 were given trivial names geranins A B, respectively. In addition, five known compounds, mahuannin B (3), reynoutrin (4), hyperin (5), methyl gallate (6), 3-β-caffeoyl-12-oleanen-28-oic acid (7), obtained. The structures proanthocyanidins elucidated by spectroscopic...
Abstract Extraction of the aerial parts Rubus coriifolius , a medicinal plant used by Maya communities in Southern Mexico to treat bloody diarrhoea, resulted isolation seven known compounds (−)‐epicatechin, (+)‐catechin, hyperin, nigaichigoside F1, β ‐sitosterol 3‐ O ‐ d ‐glucopyranoside, gallic acid and ellagic acid. All were tested for their antiprotozoal activity against Entamoeba histolytica Giardia lambia . Epicatechin was main responsible extract both protozoa, its comparable emetine,...
Chiranthodendron pentadactylon Larreat. (Sterculiaceae) is a Mexican plant used in traditional medicine for the treatment of heart disease symptoms and infectious diarrhea.To evaluate vitro antiprotozoal antibacterial activities vivo antidiarrheal activity from flowers C. using extract, fractions, major isolated flavonoids.Bioassay-guided fractionation methanol extract (MECP) led to isolation five flavonoids, tiliroside, astragalin, isoquercitrin, (+)-catechin, (-)-epicatechin. Antimicrobial...
Annona cherimola Miller (Annonaceae) is a medicinal plant frequently recommended in Mexican traditional medicine for the treatment of gastrointestinal disorders such as diarrhea and dysentery.This work was undertaken to obtain information that support use A. cherimola, on pharmacological basis using vitro computational experiments.Bioassay-guided fractionation ethanol extract leaves afforded five phenolic compounds: caffeic acid, quercetin, kaempferol, nicotinflorin, rutin.The antiprotozoal...
This study aimed to compare the antioxidant activities of extracts obtained from three plant families and evaluate their therapeutic effect on strokes. Ethanol were either leaf or aerial parts plants Annonaceae (Annona cherimola, A. diversifolia, muricata, purpurea, reticulata), Lamiaceae (Salvia amaríssima S. polystachya), Geraniaceae (Geranium niveum G. mexicanum). Extracts analyzed in terms hydroxyl radical (OH•), peroxyl (ROO•), superoxide anion (O2•−). The efficiency prevent neuronal...
Salvia amarissima Ortega was evaluated to determinate its antihyperglycemic and lipid profile properties. Petroleum ether extract of fresh aerial parts S. (PEfAPSa) a secondary fraction (F6Sa) were determine their activity in streptozo-cin-induced diabetic (STID) mice, oral tolerance tests sucrose, starch, glucose (OSTT, OStTT, OGTT, respectively), terms glycated hemoglobin (HbA1c), triglycerides (TG), high-density lipoprotein (HDL). In acute assays at doses 50 mg/kg body weight (b.w.),...
Activity-guided fractionation of the smooth muscle relaxing, chloroform-methanol (1:1) extract Conyza filaginoides (D.C.) Hieron (Asteraceae) led to isolation three flavonoids (quercetin 3-glucoside, rutin, and pinostrobin), one sterol (α-spi-nasterol), a sesquiterpenoid (β-caryophyllene 4,5-α-oxide), two triterpenoids (erythrodiol 3-β-tridecanoyloxy-28-hydroxyolean-12-ene). 3-β-Tridecanoyloxy-28-hydroxy-olean-12-ene is new naturally occurring terpenoid. All isolated compounds induced...
AbstractThe MeOH extracts from 19 Mexican medicinal plants belonging to different families have been assessed for antiprotozoal activity against Entamoeba histolytica and Giardia lamblia. Five plant extracts, derived Acalypha phleoides, Cnidoscolus tehuacanensis, Geranium niveum, Hellianthella quinquenervis Teloxys graveolens, were found possess significant both protozoa, but less potent than metronidazole. These findings tend support the ethnomedical use of species treatment infectious...