A5043967738- Toxoplasma gondii Research Studies
- Cardiovascular Effects of Exercise
- Herpesvirus Infections and Treatments
- Research on Leishmaniasis Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Parasitic Infections and Diagnostics
- Cytomegalovirus and herpesvirus research
- Genetics and Physical Performance
- Trypanosoma species research and implications
- Toxin Mechanisms and Immunotoxins
- Ubiquitin and proteasome pathways
- Immune Response and Inflammation
- Synthesis and Biological Evaluation
- Rabies epidemiology and control
- Bacteriophages and microbial interactions
- interferon and immune responses
- Adipose Tissue and Metabolism
- Tuberculosis Research and Epidemiology
- Insect and Pesticide Research
- High Altitude and Hypoxia
- RNA Interference and Gene Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular and Diving-Related Complications
- Immune Cell Function and Interaction
- Vibrio bacteria research studies
Center for Research and Advanced Studies of the National Polytechnic Institute
2016-2025
Instituto Politécnico Nacional
2003-2024
National Polytechnic School
2024
Centro de Investigación en Materiales Avanzados
2003
One of the main phenomena occurring in cellular membranes during virus infection is a change membrane permeability. It has been observed that numerous viral proteins can oligomerize and form structures known as viroporins alter permeability membranes. Previous findings have identified such cells infected with Japanese encephalitis (JEV), member same family Dengue (DENV) belongs to (Flaviviridae). In present work, we investigated whether small hydrophobic DENV protein NS2B serves viroporin...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, mutant variant Lamin A. Recently, HGPS studies have gained relevance because unraveling its underlying mechanism would help to understand physiological aging. We previously reported that CRM1-mediated nuclear protein export pathway exacerbated in cells, provoking mislocalization numerous targets CRM1. showed normalization this pharmacologically inhibiting CRM1 with LMB...
Pleopeltis crassinervata has demonstrated antimicrobial effects, including anti-Toxoplasma activity, which been attributed to the presence of compounds such as terpenes and fatty acid methyl esters. In this study, effects P. hexane subfraction one (Hsf1) on Toxoplasma gondii tachyzoite ultrastructure were evaluated using TEM SEM, lytic cycle processes adhesion, invasion, proliferation phase-contrast microscopy. Additionally, antioxidant capacity its main (phytol hexadecenoic ester)...
The intestinal epithelial barrier (IEB) depends on stable interepithelial protein complexes such as tight junctions (TJ), adherens (AJ), and the actin cytoskeleton. During inflammation, IEB is compromised due to TJ internalization remodeling. An important regulator actin-related 2/3 (Arp2/3) complex, which induces branching. Activation of Arp2/3 by nucleation-promoting factors required for formation monolayers, but little known about relevance inhibition endogenous inhibitory proteins...
Lactoferrin (LF) is a protein with antimicrobial activity, which conferred in part by 2 regions contained its N-terminal lobe. These have been used to develop the following synthetic peptides: lactoferricin17-30, lactoferrampin265-284, and LF chimera (a fusion of lactoferricin17-30 lactoferrampin265-284). We reported that these peptides antibacterial activity against several pathogenic bacteria; however, exact mechanism action has not established. Here, we report effects on viability...
Protein phosphorylation and dephosphorylation are increasingly recognized as important processes for regulating multiple physiological mechanisms. Phosphorylation is carried out by protein kinases phosphatases. Phosphoprotein phosphatases (PPPs), one of three families serine/threonine phosphatases, have great structural diversity involved in many cell functions. PP2C, a type PPP, found Leishmania , dimorphic protozoan parasite the causal agent leishmaniasis. The aim this study was to clone,...
Abstract Mitochondria are at the centre of molecular events involved in energy production, cell survival and apoptosis. Mitochondrial membrane potential (Δ ψ m ) is maintained by cellular catabolic reactions electron transport chain which cytochrome c a constituent, whereas proton leak pathway, ATP synthesis turnover consume it. alterations such as drop Δ , swelling release have been observed However, there paucity information concerning mitochondrial function course intracellular...
The number, phenotype, localisation and development of intraepithelial lymphocytes (IEL) from duodenum (Du) ileum (Il) were studied by immunohistochemistry (IHC) light electron microscopy in unweaned (0-7 weeks old) six months-old pigs. Developmental changes at birth showed that 38% the total villi IEL, mainly CD2+CD4-CD8- double negative (DN) phenotype. That proportion rose to over 50% week 5 after birth, resembling adult proportion, although still with fewer cells than CD4+ appeared...
SUMMARY Phosphatase activity of Leishmania spp. has been shown to deregulate the signalling pathways host cell. We here show that mexicana promastigotes and amastigotes secrete proteins with phosphatase culture medium, which was higher in Promastigote Secretion Medium (PSM) as compared Amastigote (ASM) not due cell lysis, since parasite viability affected by secretion process. The biochemical characterization showed present PSM dephosphorylating peptide END (pY) INASL RRA (pT)VA. In...
Toxoplasma gondii shows high dissemination and migration properties across biological barriers infecting immunologically privileged organs. uses different routes for dissemination; however, the mechanisms are not fully understood. Herein, we studied effects of proteases present in excretion/secretion products (ESPs) on MDCK cell monolayers. Ultrastructural analysis showed that ESPs disrupt intercellular junctions (IJ) adjacent cells. The tight junction (TJ) proteins ZO-1, occludin, claudin-1...
Drug repositioning is an efficient strategy to search for new treatment alternatives that especially valuable neglected parasitic diseases such as leishmaniasis. Tamoxifen and raloxifene are selective estrogen receptor modulators (SERM) have shown antileishmanial activity. Clomiphene a SERM structurally similar tamoxifen whose potential unknown. That why the objective of present work was evaluate its activity in vitro vivo, comparison with tamoxifen. The inhibitory effect against...
Abstract In Toxoplasma gondii , the conoid is a dynamic organelle composed of spiraling tubulin fibers that extrudes during egress, gliding motility, and invasion. This traverses apical polar ring (APR) in response to calcium waves plays critical role controlling parasite motility. While actomyosin-dependent extrusion beginning be understood, mechanism by which it anchored apically APR remains unclear. RNG2, protein localized at both APR, has emerged as key candidate for this function. By...