A5074705005- Sirtuins and Resveratrol in Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Natural Antidiabetic Agents Studies
- Neurological Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Nerve injury and regeneration
- Calpain Protease Function and Regulation
- Cardiac Ischemia and Reperfusion
- Pancreatic function and diabetes
- Transplantation: Methods and Outcomes
- Vagus Nerve Stimulation Research
- COVID-19 Clinical Research Studies
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Amino Acid Enzymes and Metabolism
- Magnesium in Health and Disease
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Neurological and metabolic disorders
- Natural product bioactivities and synthesis
- Ion Transport and Channel Regulation
- Phytochemistry and Biological Activities
- Cancer-related molecular mechanisms research
Instituto Nacional de Neurología y Neurocirugía
2017-2025
Universidad Nacional Autónoma de México
2022
Significance Statement The calcium-sensing receptor (CaSR) activates salt reabsorption through the sodium-chloride cotransporter (NCC) via WNK4-SPAK pathway. Glucose and other sugars are positive allosteric modulators of CaSR. This would be irrelevant for most cells that come into contact with glucose, except nephron segments beyond proximal tubule. Using in vitro vivo models, this work shows arrival glucose or fructose to distal modulates CaSR due a type II effect associated activation...
Un funcionamiento cerebral adecuado requiere de un suministro constante sustratos energéticos, principalmente glucosa, los cuales son transportados en la sangre circulando por las arterias que recorren todo el organismo. En cerebro, estas controlan rigurosamente transporte todas moléculas llegan al y están constituidas endotelio vascular cerebral, forma barrera hematoencefálica. infarto flujo sanguíneo se ve interrumpido compuestos vitales disminuye, lo provoca una alteración funciones...
This study aimed to compare the antioxidant activities of extracts obtained from three plant families and evaluate their therapeutic effect on strokes. Ethanol were either leaf or aerial parts plants Annonaceae (Annona cherimola, A. diversifolia, muricata, purpurea, reticulata), Lamiaceae (Salvia amaríssima S. polystachya), Geraniaceae (Geranium niveum G. mexicanum). Extracts analyzed in terms hydroxyl radical (OH•), peroxyl (ROO•), superoxide anion (O2•−). The efficiency prevent neuronal...
Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, associated mortality, and the permanent disability in patients that survive it. Numerous studies animal models have demonstrated protective properties of resveratrol against cerebral ischemia. Resveratrol is soluble molecule polar solvents with membrane permeability; however, it rapidly metabolized at liver also substrate ATP binding cassette transporters located blood–brain barrier....
Glucose transporter (GLUT)3 up-regulation is an adaptive response activated to prevent cellular damage when brain metabolic energy reduced. Resveratrol a natural polyphenol with anti-oxidant and anti-inflammatory features that protects neurons against induced in cerebral ischemia. Since transcription factors sensitive oxidative stress inflammation modulate GLUT3 expression, the purpose of this work was assess effect resveratrol on expression levels after Male Wistar rats were subjected 2 h...
Cerebral ischemia and resultant energy collapse: The ischemic stroke is a complex neurological condition that can be devastating for patients their families. This disease the second leading cause of death worldwide characterized by sudden decrease in cerebral blood flow due to major vessel blockage. Ischemic generates two damaged zones with distinctive metabolic characteristics. first core, region directly irrigated occluded artery. A reduction less than 20% baseline levels defines area;...