A5003915266- Pain Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Natural Compounds
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Botulinum Toxin and Related Neurological Disorders
- Hormonal and reproductive studies
- Psychedelics and Drug Studies
- Moringa oleifera research and applications
- Natural Antidiabetic Agents Studies
- Pharmacological Effects and Assays
- Neuroscience and Neuropharmacology Research
- Mindfulness and Compassion Interventions
- Essential Oils and Antimicrobial Activity
- Synthesis and biological activity
- Cannabis and Cannabinoid Research
- Advanced Glycation End Products research
- Synthesis and Biological Evaluation
- Synthesis of β-Lactam Compounds
- Muscle activation and electromyography studies
- Plant biochemistry and biosynthesis
- Medicinal Plants and Neuroprotection
- Neurological disorders and treatments
- Pancreatitis Pathology and Treatment
Universidad de Colima
2014-2023
Center for Research and Advanced Studies of the National Polytechnic Institute
1998-2003
Centro de Investigación en Materiales Avanzados
2000
Agastache mexicana is a plant in high demand that has long been used Mexican folk medicine to treat anxiety, insomnia, and stomachache, among other afflictions. Ursolic acid acacetin were isolated identified as two possible active compounds of A. aerial parts. An antinociceptive response was demonstrated significant dose-dependent manner with ursolic (i. p. o.) comparison the analgesic diclofenac by using writhing test mice. Moreover, also produced concentration-dependent spasmolytic major...
Objective To evaluate the preventive effects of Moringa oleifera on metabolic syndrome (MS) in male Wistar rats. Methods MS was induced by feeding rats a high-fat diet and drinking water containing 10% fructose for 6 weeks. In group, M. orally administered 3 weeks prior to induction MS, while treatment after onset MS. The groups were compared with control group untreated Fasting glucose, oral glucose tolerance, insulin total cholesterol, triglycerides, abdominal circumference, systolic...
Objective Our aim was to assess the effects of dietary iron, and compound capsaicin, on hemoglobin as well metabolic indicators including blood glucose, cholesterol, triglycerides, insulin, glucose tolerance. Materials Methods animal model Wistar rat, fed a chow diet, with or without experimentally induced diabetes. Diabetic males were control, low, high-iron diets, latter, capsaicin. Healthy rats identical but capsaicin supplement. We then measured parameters listed above, using Student...
Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured long-term treatments with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on glycemia during next six h after an oral or intraperitoneal administration treatment healthy diabetic rats. In study, streptozotocin-nicotinamide male Wistar rats were used a model. 10 mg/kg did not modify...
Abstract Pain-induced functional impairment in the rat (PIFIR) is a model of inflammatory and arthritic pain similar to that clinical gout. Nociception induced by intra-articular injection uric acid into right hind limb, inducing its dysfunction. Animals then receive analgesic drugs recovery functionality over time assessed as an expression antinociception. We have examined role peripheral prostaglandins synthesized cyclooxygenase-1 (COX-1) cyclooxygenase-2 (COX-2) using PIFIR model....
It is considered that natural products used in folk medicine can potentiate the effect of drugs. The aim this study was to evaluate pharmacological interaction between ursolic acid, a triterpene isolated from herbal medicines treat pain, and analgesics diclofenac or tramadol. Individual dose-response curves antinociceptive these compounds were built calculate ED<sub>50</sub>, as well interaction, by using isobolographic analysis. All treatments decreased significantly dose-dependent manner...
Different analgesic combinations with caffeine have shown this drug to be capable of increasing the effect. Many nonsteroidal anti-inflammatory drugs (NSAIDs) been carried out, but, in regard opioids, only morphine and tramadol reported. The antinociceptive synergism mechanism these is not well understood. purpose present study was determine participation spinal supraspinal opioidergic serotonergic systems synergic effect tramadol+caffeine combination rat formalin test. At level, opioid...
Abstract Natural products are recognized as potential analgesics since many of them part modern medicine to relieve pain without serious adverse effects. The aim this study was investigate the antinociceptive and anti-inflammatory activities an aqueous extract Brassica oleracea var. italica sprouts (AEBS) one its main reported bioactive metabolites sulforaphane (SFN). Antinociceptive activity AEBS (30, 100, 300 mg/kg, i.p. or 1000 2000 p.o.) SFN (0.1 i.p.) evaluated in plantar test rats...
We investigated the antinociceptive properties of dexketoprofen trometamol (S(+)‐ketoprofen tromethamine salt; SKP), a new analgesic, antiinflammatory drug, using pain‐induced functional impairment model in rat (PIFIR), an animal arthritic pain. SKP was compared with racemic ketoprofen salt (rac‐KP), R(−)‐ketoprofen (RKP), ketorolac (KET), and morphine (MOR). also assessed effects flurbiprofen (rac‐FB) its enantiomers (SFB RFB) same model. Groups six rats received either vehicle or analgesic...
Abstract In the present study, analgesic efficacy and possible development of tolerance produced by combination metamizol+morphine (562.3:5.6 mg/kg) during subchronic treatment (6 12 days) in arthritic rats using PIFIR model was evaluated. This maximum (AUC E = 353.4 ± 24.7 au) when compared with morphine 5.6 mg/kg 196.6 35.3 au), metamizol 562.3 262.8 10.2 10 316.6 31.0 given a single dose. The results were essentially same administered for 6 325.4 13.1 or days 354.5 9.6 au). addition,...
Pharmacological synergism is a current strategy for the treatment of pain. However, few studies have been explored to provide evidence possible between non-steroidal anti-inflammatory drug (NSAID) and cannabinoid agonist, in order establish which combinations might be effective manage The aim this study was explore ibuprofen (IBU) synthetic WIN 55,212-2 (WIN) improve pain relief by analyzing degree participation CB1 CB2 receptors antinociceptive using an experimental model Wistar rats....