A5025801410- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Ion Channels and Receptors
- Cardiac electrophysiology and arrhythmias
- Biochemical effects in animals
- Genetic Neurodegenerative Diseases
- Aldose Reductase and Taurine
- RNA modifications and cancer
- Muscle Physiology and Disorders
- ATP Synthase and ATPases Research
- Adipose Tissue and Metabolism
- Calcium signaling and nucleotide metabolism
- Cardiac Ischemia and Reperfusion
- MicroRNA in disease regulation
- Neurotransmitter Receptor Influence on Behavior
- Pancreatic function and diabetes
- Cannabis and Cannabinoid Research
- Endoplasmic Reticulum Stress and Disease
- Neuroendocrine regulation and behavior
- Natural Antidiabetic Agents Studies
- Circular RNAs in diseases
- Diatoms and Algae Research
- Cardiovascular Effects of Exercise
- Gastrointestinal motility and disorders
- Diet and metabolism studies
Universidad de Colima
2015-2025
Universidad Nacional Autónoma de México
2023
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2017-2022
Baylor College of Medicine
2012-2017
Instituto Politécnico Nacional
2010
Center for Research and Advanced Studies of the National Polytechnic Institute
2009-2010
Abstract Mutations in the RYR1 gene cause severe myopathies. Mice with an I4895T mutation type 1 ryanodine receptor/Ca 2+ release channel (RyR1) display muscle weakness and atrophy, but underlying mechanisms are unclear. Here we show that RyR1 decreases amplitude of sarcoplasmic reticulum (SR) Ca transient, resting cytosolic levels, triadin content calsequestrin (CSQ) localization to junctional SR, increases endoplasmic (ER) stress/unfolded protein response (UPR) mitochondrial ROS...
The Rbfox family of RNA-binding proteins is highly conserved with established roles in alternative splicing (AS) regulation.High-throughput studies aimed at understanding transcriptome remodeling have revealed skeletal muscle as displaying one the largest number AS events.This finding consistent requirements for tissue-specific protein isoforms needed to sustain muscle-specific functions.Rbfox1 abundant vertebrate brain, heart and muscle.Genome-wide genetic approaches linked Rbfox1 gene...
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, often diagnosed at advanced stages due to insufficient early screening and monitoring. MicroRNAs (miRNAs) are key regulators of gene expression potential biomarkers for cancer diagnosis. This study investigated diagnostic miRNAs in Extracellular Vesicles (EVs) from HCC. miRNA EVs was analyzed using HCC cell lines, circulating a Diethylnitrosamine (DEN)-induced tumor rat model, plasma samples patients. Receiver Operating...
Ca(2+) influx through CaV1.1 is not required for skeletal muscle excitation-contraction coupling, but whether permeation during sustained activity plays a functional role in mammalian has been assessed.We generated mouse with binding and/or defect the voltage-dependent channel, CaV1.1, and used imaging, western blotting, immunohistochemistry, proximity ligation assays, SUnSET analysis of protein synthesis, imaging techniques to define pathways modulated by CaV1.1. We also assessed fiber type...
Ca2+ permeation and/or binding to the skeletal muscle L-type channel (CaV1.1) facilitates activation of Ca2+/calmodulin kinase type II (CaMKII) and store refilling reduce fatigue atrophy (Lee, C. S., Dagnino-Acosta, A., Yarotskyy, V., Hanna, Lyfenko, Knoblauch, M., Georgiou, D. K., Poché, R. Swank, M. W., Long, C., Ismailov, I. I., Lanner, J., Tran, T., Dong, Rodney, G. G., Dickinson, E., Beeton, Zhang, P., Dirksen, Hamilton, S. L. (2015) Skelet. Muscle 5, 4). Mice with a mutation (E1014K)...
Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured long-term treatments with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on glycemia during next six h after an oral or intraperitoneal administration treatment healthy diabetic rats. In study, streptozotocin-nicotinamide male Wistar rats were used a model. 10 mg/kg did not modify...
Abstract Background Statins are widely used drugs for the treatment of hyperlipidemia. Though relatively safe, some individuals taking statins experience rhabdymyolysis, muscle pain, and cramping, a condition termed statin-induced myopathy (SIM). To determine if mutations in skeletal calcium (Ca 2+ ) release channel, ryanodine receptor type 1 (RyR1), enhance sensitivity to SIM we tested effects simvastatin, statin that produces highest incidence humans, mice with mutation (Y524S, ‘YS’) RyR1....
Abstract Hepatocellular carcinoma (HCC) progression is associated with dysfunctional mitochondria and bioenergetics impairment. However, no data about the relationship between mitochondrial supercomplexes (hmwSC) formation ATP production rates in HCC are available. Our group has developed an adenosine derivative, IFC-305, which improves function, it been proposed as a therapeutic candidate for HCC. We aimed to determine role of IFC-305 on both structure sequential cirrhosis-HCC model rats....
The process of Ca2+ release from sarcoplasmic reticulum (SR) comprises 4 phases in smooth muscle cells. Phase 1 is characterized by a large increase the intracellular concentration ([Ca2+]i) with minimal reduction free luminal SR [Ca2+] ([Ca2+]FSR). Importantly, active ATPases (SERCA pumps) are necessary for phase to occur. This situation cannot be explained standard kinetics that involves fixed amount binding sites. A new mathematical model was developed assumes an increasing buffering...
PKC inhibitors stimulate Ca2+ release from internal stores in diverse cell types. Our data indicate that this action cannot be explained by an increased agonist-induced IP3 production or overloaded SR pool smooth muscle cells guinea pig urinary bladder. The incubation of these with three different inhibitors, such as Go6976, Go6983, and BIM 1, resulted a higher leak revealed inhibition the SERCA pump thapsigargin. This leakage was sensitive to protein translocation emetine anisomycin. Since...
The cafeteria diet (CAF) is a superior model in animal experiments compared to the conventional high-fat (HFD), effectively inducing obesity, metabolic disturbances and multi-organ damage. Nevertheless, its impact on gut microbiota composition during progression of along with repercussions enteric nervous system (ENS) gastrointestinal motility has not been completely elucidated. To gain more insight into effects CAF gut, C57BL/6 mice were fed or standard for 2 8 weeks. CAF-fed experienced...
Hepatocellular carcinoma (HCC) is the most common liver cancer, often diagnosed at advanced stages due to inadequate early diagnostic methods. MicroRNAs (miRNAs) play crucial roles in gene expression regulation and are possible biomarkers for molecular diagnosis several diseases, including cancer. This study aimed investigate potential of miRNAs contained Extracellular Vesicles (EVs) from HCC. The miRNA EVs was analyzed HCC cell lines, circulating a Diethylnitrosamine (DEN)-induced rat...
Taurine is an abundant metabolite associated with regulation of cell volume. Several signaling pathways are stimulated at a micromolar concentrations taurine. However, most the experimental studies employ this compound very high concentration (tens millimolar). In study, role chronic treatment dosage taurine in physical performance skeletal muscle castrated-aged mice was characterized. administered drinking water (800 μM) to 9-months-old castrated (or sham) approximately 20 mg/kg per day for...
Abstract Hepatocellular carcinoma (HCC) has become highly relevant in oncology research because of its high mortality rate and difficult diagnosis treatment. Most chronic liver diseases, including HCC, are characterized by bioenergetics impairment associated with dysfunctional mitochondria. However, no data available about the relationship between mitochondrial supercomplexes formation ATP production rates HCC. Our group developed an adenosine derivative, IFC-305, which improves function, it...
Diatoms are ubiquitous in all aquatic areas. Recently, these marine microorganisms gained attention because of their health benefits, especially when addressing the problem antibiotic resistance. In this study, Actinoptychus octonarius Ehrenberg was identified by its ultrastructural details Scanning Electron Microscopy (SEM). Additionally, antibacterial properties A. were evaluated employing method disk diffusion against Staphylococcus aureus and Vibrio vulnificus bacteria. Four extracts...