A5093069125- ATP Synthase and ATPases Research
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
Universidad de Colima
2023-2025
Universidad Nacional Autónoma de México
2023
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, often diagnosed at advanced stages due to insufficient early screening and monitoring. MicroRNAs (miRNAs) are key regulators of gene expression potential biomarkers for cancer diagnosis. This study investigated diagnostic miRNAs in Extracellular Vesicles (EVs) from HCC. miRNA EVs was analyzed using HCC cell lines, circulating a Diethylnitrosamine (DEN)-induced tumor rat model, plasma samples patients. Receiver Operating...
BackgroundType 2 diabetes (T2D) is a complex metabolic ailment marked by global high prevalence and significant attention in primary healthcare settings due to its elevated morbidity mortality rates. The pathophysiological mechanisms underlying the onset progression of this disease remain subjects ongoing investigation. Recent evidence underscores pivotal role intricate intercellular communication network, wherein cell-derived vesicles, commonly referred as extracellular vesicles (EVs),...
Abstract Hepatocellular carcinoma (HCC) progression is associated with dysfunctional mitochondria and bioenergetics impairment. However, no data about the relationship between mitochondrial supercomplexes (hmwSC) formation ATP production rates in HCC are available. Our group has developed an adenosine derivative, IFC-305, which improves function, it been proposed as a therapeutic candidate for HCC. We aimed to determine role of IFC-305 on both structure sequential cirrhosis-HCC model rats....
Hepatocellular carcinoma (HCC) is the most common liver cancer, often diagnosed at advanced stages due to inadequate early diagnostic methods. MicroRNAs (miRNAs) play crucial roles in gene expression regulation and are possible biomarkers for molecular diagnosis several diseases, including cancer. This study aimed investigate potential of miRNAs contained Extracellular Vesicles (EVs) from HCC. The miRNA EVs was analyzed HCC cell lines, circulating a Diethylnitrosamine (DEN)-induced rat...
Abstract Hepatocellular carcinoma (HCC) has become highly relevant in oncology research because of its high mortality rate and difficult diagnosis treatment. Most chronic liver diseases, including HCC, are characterized by bioenergetics impairment associated with dysfunctional mitochondria. However, no data available about the relationship between mitochondrial supercomplexes formation ATP production rates HCC. Our group developed an adenosine derivative, IFC-305, which improves function, it...