A5025279246- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Heart rate and cardiovascular health
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Ion Channels and Receptors
- Nicotinic Acetylcholine Receptors Study
- Connexins and lens biology
Cedars-Sinai Medical Center
2024
Universidad de Colima
2014-2020
Pannexins are large-pore ion channels expressed throughout the mammalian brain that participate in various neuropathologies; however, their physiological roles remain obscure. Here, we report pannexin1 (Panx1) can be synaptically activated under recording conditions rodent acute hippocampal slices. Specifically, NMDA receptor (NMDAR)-mediated responses at mossy fiber to CA3 pyramidal cell synapse were followed by a slow postsynaptic inward current could activate cells but was absent Panx1...
The aim of this work was to determine whether Capsaicin may exert a vascular regulation through the activation CB1 and/or CB2 receptors causing vasorelaxation in rat aorta. Our results show location TRPV1 mainly endothelial and smooth muscle cells membrane. Nevertheless, caused artery mechanism independent TRPV1, since specific antagonists Capsazepine SB-366791 did not block effect Capsaicin. Because significant expression has been previously reported aorta, we used for these two prior...