A5056021798- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects and Toxicity Studies
- Sleep and Wakefulness Research
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Developmental and Educational Neuropsychology
- Infectious Encephalopathies and Encephalitis
- Educational Research and Science Teaching
- Growth Hormone and Insulin-like Growth Factors
- Stress Responses and Cortisol
- Cell death mechanisms and regulation
- Attention Deficit Hyperactivity Disorder
- Infant Health and Development
- Neuroscience and Neural Engineering
- Hypothalamic control of reproductive hormones
- Medicinal Plants and Bioactive Compounds
- Medical research and treatments
- Diet and metabolism studies
Universidad Veracruzana
2016-2025
Centro de Investigación en Materiales Avanzados
2004-2011
VA Greater Los Angeles Healthcare System
2006-2010
University of California, Los Angeles
2006-2010
Instituto Nacional de Psiquiatría
2004-2007
The extraction of plant constituents is essential to isolate biologically active compounds, aimed understand their role on the treatment diabetes.This study was designed explore preliminary phytochemical and physicochemical analysis Carica papaya L., Caricaceae, leaf, further evaluation its hypoglycemic effect diabetic rats. C. leaves were extracted using chloroform, n-hexane or ethanol. For each extract a screening performed. tests conducted in triplicate qualitative quantitative...
Summary Status epilepticus in the immature brain induces neuronal injury hippocampal formation, but mode and mechanism of death are poorly understood. Our laboratory has recently investigated role caspase‐3, ‐8, ‐9 injury, using a lithium–pilocarpine model status 2‐week‐old rat pups. results showed that dying neurons dentate gyrus CA1‐subiculum area do not share same death. In CA1‐subiculum, caspase‐8 upregulation preceded caspase‐3 activation morphologically necrotic neurons. The...
Summary: Purpose: To evaluate hypnotic and anticonvulsant activities of Annona diversifolia Saff. palmitone by using behavior electroencephalographic (EEG) analysis in an experimental model focal seizures rats. Methods : For assessment, EEG polysomnographic slow‐wave sleep (SWS) rapid eye movement (REM) for a 1 h period were performed after vehicle, A. extract or palmitone, administration. effect, 60 minutes treatments, analyzed during penicillin‐induced seizures. Latency to the onset first...
Abstract Interleukin‐1β (IL‐1β) is associated with seizure‐induced neuronal cell death in the adult brain. The contribution of IL‐1β to injury induced by status epilepticus (SE) immature brain remains unclear. In present study, we investigated effects administration on hippocampal SE brain, and role type I receptor (IL‐1RI). was lithium–pilocarpine 14‐days‐old (P14) rat pups. Six hours after onset, pups were i.c.v. injected right ventricle (0, 0.3, 3, 30, or 300 ng), 30 ng IL‐1RI antagonist...
In mammals, the preBötzinger complex (preBötC) is a bilateral and symmetrical neural network located in brainstem which essential for generation modulation of respiratory rhythm. Few human studies have addressed preBötC its relationship with neurological diseases has not been described. However, possibility that important control breathing, potentially involved humans, suggested based on pharmacological manipulation lesion animal models, both vivo vitro. this review, we describe effects...
The goal of this research was to evaluate the effect DM type 2 (DM2) on SE severity, neurodegeneration, and brain oxidative stress (OS) secondary seizures.
It is traditionally thought that excitotoxic necrosis a passive mechanism does not require the activation of cell death program. In this study, we examined contribution cytochrome c-dependent mitochondrial pathway to neuronal necrosis, induced by exposing cultured cortical neurons 1 mM glutamate for 6 hr and blocked NMDA antagonist, dizocilpine. Glutamate treatment early c release, followed caspase-9 caspase-3. Preincubation with inhibitor z-LEHD-fmk, caspase-3 z-DEVD-fmk, or specific...
The question of whether repeated single seizures cause neuronal death in the adult human brain is great clinical importance and might have broad therapeutic implications. Reviewed here are recent studies on effects (in absence status epilepticus) hippocampal volume markers blood surgically ablated hippocampi.
The pre-Bötzinger complex (preBötC) underlies inspiratory rhythm generation. As a result of network interactions, preBötC neurons burst synchronously to produce rhythmic premotor activity. Each consists action potentials (APs) on top 10- 20-mV synchronous depolarization lasting 0.3-0.8 s known as drive potential. mechanisms underlying the initiation and termination are unclear, role Ca(2+) is matter intense debate. To investigate extracellular in termination, we substituted with Sr(2+). We...
Autism spectrum disorder is associated with alterations in GABAergic and glutamatergic neurotransmission. Here, we aimed to determine the concentration of GABA, glutamate, glutamine, aspartate, taurine, glycine brain tissue plasma rats prenatally exposed valproic acid (VPA), a well-characterized experimental model autism. Pregnant were injected VPA (600mg/Kg) during twelfth-embryonic-day. Control saline. On fourteen-postnatal-day, from both groups (males females) anesthetized, euthanized by...