Background: Systemic lupus erythematosus (SLE)-associated myelitis or (LM), one of the twelve neuropsychiatric (NPSLE) syndromes, is a rare but severe complication lupus. In this study, we observed clinical and imaging profiles LM patients to assess long-term outcomes. Methods: This was retrospective study; data with follow-up were extracted from registry in last 15 years (2007-2022). Clinically, they divided as grey matter (GMM) versus white (WMM). Disease activity assessed by SLE Activity...

SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare autoinflammatory condition describing the constellation of inflammatory skin, bone, joint manifestations which result in diagnostic difficulty therapeutic challenge. Here, we present case young male diagnosed with osteoarticular cutaneous involvement from an early age his life. He suffered challenges for long time was hence inadequately treated. had minimal response to conventional DMARDs but showed excellent...

Introduction: Neuro-Behçet's disease (NBD) is an uncommon presentation in Behçet's (BD) with severe course and worse prognosis.Both vascular NBD without the classical triad of BD a single patient rarely reported.Case Presentation: Here 48-year-old male had extensive aortic aneurysm eroding vertebra for which he was diagnosed as BD.Two years later, presented headache cerebrovascular accident, his brain imaging showed hyperintensity right thalamus, basal ganglia, temporal lobe, internal...

Dysregulation of interferon-alpha (IFN-α) is considered central to the immunological abnormalities observed in SLE. Short-term mortality during high disease activity lupus up 30%. Adenovirus vector-introduced IFN-α into a lupus-prone mouse causes development glomerulonephritis and death within weeks. We studied serum as biomarker in-hospital patients SLE with activity. Serum (ELISA) was measured hospitalised for acute severe tertiary care rheumatology unit India levels were compared between...

<h3>Background:</h3> Pulmonary arterial hypertension (PAH) is a severe complication that frequently overlooked in patients with systemic lupus erythematosus (SLE). The clustering of SLE-PAH garnering attention as it believed to have distinct underlying mechanisms and responses treatment. Therefore, this study aims classify into various clusters based on auto-antibody profiles examine these clusters' long-term outcomes. <h3>Objectives:</h3> main aim was categorise different their autoantibody...

Background: Quantitative measurement of valproate and lithium induced tremor using hand steadiness tester their comparison in bipolar disorder. Methods: 200 newly diagnosed patients disorder were randomly allocated into two equal groups receiving (300mg twice daily) sodium (500 mg after they fulfilled the inclusion / exclusion criteria study. 87 from Lithium group 93 Valproate completed Hand Tremor was assessed quantitatively at 0, 6, 12, 18 24 weeks tester. Anxiety level study subjects to...

INTRODUCTION PVD, one of the major macrovascular complications T2DM, usually begins at an earlier age and remains subclinical for a long duration. So early detection PVD will help to assess its true prevalence hence prevention overt manifestation. OBJECTIVES To in T2 DM from Eastern India correlation with clinical biochemical parameters METHODS It was cross sectional study consecutive diabetes patients attending OPD 2015 January 2016 July. Each subjected meticulous history, measurement ABPI...

Immunoglobulin G4-related disease (IgG4-RD) coexisting with clinically apparent autoimmune diseases, such as rheumatoid arthritis (RA) or antiphospholipid syndrome (APS), is a rarely documented combination in the scientific literature. In this case-based review, we present 2 intriguing cases preexisting namely, RA and primary APS, who exhibited coexistent IgG4- related lesions at unusual sites. The first case pertains to patient known presented an encasing mass esophagus leading stricture,...

Objective: The objective of this study was to appraise the correlation and agreement RAPID 3 with DAS 28 CDAI in terms measuring disease activity/severity for monitoring response treatment at 2 4 month follow up. Methods: 105 adult literate persons having rheumatoid arthritis according 2010 ACR EULAR revised criteria were included. They evaluated activity by 28, CDAI, scores. Response up measured these Achievement target defined as conversion from high/moderate initial visit low...

Abstract Systemic lupus erythematous–associated pulmonary arterial hypertension (SLE-PAH) is one of the important causes mortality in patients. Different autoantibodies are associated with SLE-PAH which can predict its future development. The objective study was to identify distinct autoantibody-based clusters patients and compare demographic characters, clinical phenotypes, therapeutic strategy across clusters. Three autoantibody were identified using k-means cluster analysis 71 Cluster1...

Abstract Introduction IgG4RD overlapping with clinically overt autoimmune diseases (Rheumatoid arthritis ( RA) or anti-phospholipid syndrome (APS) is rarely reported in the literature. Here we report a tale of two cases known – RA and primary APS presented IgG4-related lesions involving unusual sites oesophagus right atrium heart respectively Case The first case was dysphagia, imaging suggestive encasing mass causing stricture , biopsy IgG4RD. second patient breathlessness, revealed atrial...

Abstract Blau syndrome ( BS ) , considered a rare pediatric autoinflammatory disease, is characterized by triad of granulomatous arthritis, dermatitis and uveitis . Here we present tale three families evaluated in our outpatient department over the last two years (2020-2022). More than one member family was affected with either skin, ophthalmological joint involvement biopsy-proven granuloma or genetic mutation at NOD2 gene suggesting diagnosis BS. The third had novel pathogenic clinical features

Abstract Background/Aims Myelitis is a severe yet rare manifestation of systemic lupus erythematosus (SLE). Literature on myelitis limited to case reports and series. Birnbaum et al. reported the largest series (n = 22) with two distinct phenotypes based clinical imaging findings mechanistic therapeutic implications. Further validation these subtypes not date. The objective study was identify in compare activity outcomes formulation prediction model for survival. Methods This retrospective...

ABSTRACT Background Axial spondyloarthropathy (SpA) is seronegative arthritis which mainly affects young adults and causes much morbidity. Tumor necrosis factor-alpha (TNF-α) one of the main mediators inflammation in joints enthuses SpA. Nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic (DMARDs), biologics like TNF-α inhibitors are mainstay therapy However, India, cost limiting factor use for treatment SpA eligible patients. Thalidomide an oral inhibitor has...

Background PAH is a well-recognized but infrequent manifestation of SLE. Often insidious in onset, may have progressed for while, before symptoms manifest. Prediction clinical risk benefit during the follow-up patient with Objectives The aim study was to develop prediction algorithm patients SLE using and auto-antibody variables. Methods included from INSPIRE cohort which is, national multi-center enrolling disease duration less than three years. Lupus symptomatic confirmed by transthoracic...