A5068905399- Cervical Cancer and HPV Research
- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- Transgenic Plants and Applications
- Hepatitis B Virus Studies
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Hemoglobin structure and function
- Chronic Lymphocytic Leukemia Research
- Viral Infections and Immunology Research
- Skin and Cellular Biology Research
- Hepatitis Viruses Studies and Epidemiology
- Developmental Biology and Gene Regulation
- Porphyrin Metabolism and Disorders
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Biochemical and Structural Characterization
- Phytochemicals and Antioxidant Activities
- SARS-CoV-2 detection and testing
- Erythrocyte Function and Pathophysiology
- Animal Virus Infections Studies
- Animal testing and alternatives
National Institute of Cancer Prevention and Research
2016-2025
Post Graduate Institute of Medical Education and Research
2023-2024
Delhi Pharmaceutical Science and Research University
2022-2024
Chandigarh University
2023-2024
Baby Memorial Hospital
2017-2024
Noida International University
2024
Government of India
2021-2023
Ministry of Health and Family Welfare
2021-2023
International Medical University
2023
National Institute of Health and Family Welfare
2023
Cancer immune evasion represents a leading hallmark of cancer, posing significant obstacle to the development successful anticancer therapies. However, landscape cancer treatment has significantly evolved, transitioning into era immunotherapy from conventional methods such as surgical resection, radiotherapy, chemotherapy, and targeted drug therapy. Immunotherapy emerged pivotal component in treatment, harnessing body’s system combat offering improved prognostic outcomes for numerous...
Recent mouse knockout studies identified adapter protein-2 associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. Potent small-molecule inhibitors of AAK1 have been and show efficacy in various rodent pain models. (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211) (34) was highly selective, CNS penetrant, potent inhibitor from novel class bi(hetero)aryl ethers. BMS-986176/LX9211 showed excellent two models central...
Abstract Cervical cancer is the most common gynaecological and reaches an alarming stage. HPVs are considered main causative agents for cervical other sexually transmitted infections across globe. Currently, three prophylactic vaccines available against HPV with no therapeutic values. Due to a lack of effective measures, infection spreading in uncontrolled manner. Next-generation vaccine needed have both values HPV. Here first time we designed multi-epitope chimeric using oncogenic strain 16...
Understanding the antibody response to SARS-CoV-2, virus responsible for COVID-19, is crucial comprehending disease progression and significance of vaccine therapeutic development. The emergence highly contagious variants poses a significant challenge humoral immunity, underscoring necessity grasping intricacies specific antibodies. This review emphasizes pivotal role antibodies in shaping immune responses their implications diagnosing, preventing, treating SARS-CoV-2 infection. It delves...
According to the 2018 WHO R&D Blueprint, Nipah virus (NiV) is a priority disease, and development of vaccine against NiV strongly encouraged. criteria used categorize zoonotic diseases, stage III disease that can spread people cause unpredictable outbreaks. Since 2001, has caused annual outbreaks in Bangladesh, while India it occasional estimates, mortality rate for infected individuals ranges from 70 91%. Using immunoinformatic approaches anticipate epitopes MHC-I, MHC-II, B-cells, they...
Galectin-3 is a member of family β-galactoside-binding proteins. A substantial body literature reports that galectin-3 plays important roles in cancer, inflammation, and fibrosis. Small-molecule inhibitors, which are generally lactose or galactose-based derivatives, have the potential to be valuable disease-modifying agents. In our efforts identify novel disaccharide mimics improve drug-like properties, we found one monosaccharide subunits can replaced with suitably functionalized...
Adverse drug reactions to 5-Fluorouracil(5-FU) is frequent and largely attributable genetic variations in the DPYD gene, a rate limiting enzyme that clears 5-FU. The study aims at understanding pharmacogenetic landscape of variants south Asian populations.Systematic analysis population scale genome wide datasets over 3000 Asians was performed. Independent evaluation performed small cohort patients.Our revealed significant differences allelic distribution different ethnicities.This first...
Cervical cancer is the most common gynecological malignancy in developing countries like India. In addition to human papillomavirus (HPV) infection, host genetic factors play an important role viral persistence and neoplastic growth. IL-10, a multifunctional cytokine, plays active promote tumor growth presence of HPV. The present study aims find out impact IL-10 promoter polymorphisms at -1082A/G (rs1800896), -819C/T (rs1800872), -592C/A (rs1800871) sites along with production HPV infection...
Abrus precatorius is a tropical medicinal plant with multiple benefits whose seeds have not yet been studied against cervical cancer. Herein, we assessed the antioxidant and antiproliferative properties of seed extracts (ethyl acetate 70% ethanol) prepared from Soxhlet Maceration extraction methods Hep2C HeLa Cells. We observed that APE (Sox) extract had significantly higher total flavonoid content, APA (Mac) high phenolic tannin content. Further, HPLC analysis revealed presence tannic acid...
Hepatitis E virus (HEV) is a foodborne transmitted through the faecal-oral route that causes viral hepatitis in humans worldwide. Ever since its discovery as zoonotic agent, HEV was isolated from several species with an expanding range of hosts. possesses features other RNA viruses but also has certain HEV-specific traits make viral-host interactions inimitable. leads to severe morbidity and mortality immunocompromised people pregnant women across world. The situation underdeveloped...