A5041093107- Virology and Viral Diseases
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Rabies epidemiology and control
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- Cardiovascular Disease and Adiposity
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Acute Myocardial Infarction Research
- SARS-CoV-2 detection and testing
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Biomarkers in Disease Mechanisms
- Advancements in Transdermal Drug Delivery
- Dialysis and Renal Disease Management
- vaccines and immunoinformatics approaches
- Respiratory viral infections research
- Chronic Kidney Disease and Diabetes
- Renal cell carcinoma treatment
- Long-Term Effects of COVID-19
- Vector-borne infectious diseases
- Nanoparticle-Based Drug Delivery
- Glutathione Transferases and Polymorphisms
- Cardiovascular Health and Disease Prevention
ICMR-National Institute of Virology
2011-2024
ACPM Dental College and Hospital
2015-2024
Krishna Institute of Medical Sciences Deemed University
2024
G.S. Science, Arts And Commerce College
2022
Dr. D. Y. Patil Medical College, Hospital and Research Centre
2019
An intrafamilial outbreak in West Bengal, India, involving 5 deaths and person-to-person transmission was attributed to Nipah virus. Full-genome sequence of virus (18,252 nt) amplified from lung tissue showed 99.2% nt 99.8% aa identity with the Bangladesh-2004 isolate, suggesting a common source
Abstract The COVID-19 pandemic is a global health crisis that poses great challenge to the public system of affected countries. Safe and effective vaccines are needed overcome this crisis. Here, we develop assess protective efficacy immunogenicity an inactivated SARS-CoV-2 vaccine in rhesus macaques. Twenty macaques were divided into four groups five animals each. One group was administered placebo, while three immunized with different candidates BBV152 at 0 14 days. All challenged fourteen...
The apprehension of needles related to injection site pain, risk transmitting bloodborne pathogens, and effective mass immunization have led the development a needle-free system (NFIS). Here, we evaluated efficacy NFIS needle (NIS) for delivery immunogenicity DNA vaccine candidate ZyCoV-D in rhesus macaques against SARS-CoV-2 infection. Briefly, 20 were divided into 5 groups (4 animals each), that is, I (1 mg dose by NIS), II (2 III NFIS), IV NFIS) V (phosphate-buffer saline [PBS])....
Since 2018, the Indian state of Kerala has reported four Nipah virus (NiV) disease outbreaks, raising concerns about NiV spillover from bats to human population. Considering this, a cross-sectional study was undertaken in
Abstract Background In June 2019, Nipah virus (NiV) infection was detected in a 21-year-old male (index case) of Ernakulum, Kerala, India. This study undertaken to determine if NiV circulation Pteropus species ( spp) those areas where the index case had visit history 1 month. Methods Specialized techniques were used trap medius bats (random sampling) vicinity area. Throat and rectal swabs samples 141 along with visceral organs 92 collected detect presence by real-time reverse...
Sir, Coronaviruses belong to the family Coronaviridae with a single-stranded, positive-sense RNA genome (26-32 kb), and are known cause infections in humans animals. Cases of pneumonia unknown aetiology were reported Wuhan, China, early December 2019, identified be caused by novel coronavirus, named as severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)1. As May 27, 2020, more than 5.7 million cases worldwide above 3,52,000 deaths2. efforts being made for development vaccines...
Bats are considered to be the natural reservoir for many viruses, of which some potential human pathogens. In India, an association Pteropus medius bats with Nipah virus was reported in past. It is suspected that recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also has its bats. To assess presence CoVs bats, we performed identification and characterization bat CoV (BtCoV) P. Rousettus species from representative States collected during 2018 2019.Representative...
Abstract The COVID-19 pandemic is a global health crisis that has severely affected mankind and posed great challenge to the public system of countries. availability safe effective vaccine need hour overcome this crisis. Here, we have developed assessed protective efficacy immunogenicity an inactivated SARS-CoV-2 (BBV152) in rhesus macaques (Macaca mulata). Twenty were divided into four groups five animals each. One group was administered placebo while three immunized with different...
Abstract Vaccines remain the key protective measure to achieve herd immunity control disease burden and stop COVID-19 pandemic. We have developed assessed immunogenicity efficacy of two formulations (1mg 2mg) ZyCoV-D (a plasmid DNA based vaccine candidates) administered through Needle Free Injection System (NFIS) syringe-needle (intradermal) in rhesus macaques with three dose regimens. The candidate 2mg using elicited a significant immune response development SARS-CoV-2 S1 spike region...
Abstract The present manuscript deals with experimental infections of bonnet macaques ( Macaca radiata ) to study disease progression for better insights into the Kyasanur Forest Disease (KFD) pathogenesis and transmission. Experimentally, 10 monkeys were inoculated KFD virus (KFDV) (high or low dose) regularly monitored sampled various body fluids tissues at preset time points. We found that only 2 out animals showed marked clinical signs becoming moribund, both in dose group, even though...
Kyasanur Forest disease virus (KFDV) is a tick-borne Flavivirus that causes severe illness in humans. Disease spectrum can vary from subclinical infection to fatal cases with hemorrhagic complications. The pathology of KFDV remains incompletely understood.This study describes the histopathologic and immunohistochemical findings experimentally infected infant CD-1 mice an early passage human isolate.Acute histological changes were primarily seen brain. included gliosis, inflammatory response,...
Background: It is predicted that there will be an increase of 111% in cardiovascular deaths India by the year 2020 compared to 1990. This much higher than any other region both Asia as well outside Asia. The objective this study was incidence cardiac arrhythmias acute myocardial infarction during first 48 hours.Methods: descriptive conducted over a period two years from April 2016 January 2017. A total 102 patients were studied. They admitted ICU. Their admission done soon they had chest...
Background: The present study was conducted to assess the clinical profile of type 2 diabetes patients presenting with diabetic ketoacidosis and review their biochemical parameters at time presentation. Methods: an analytical, cross-sectional over period two years. All admitted during constituted population, after being subjected prefixed selection criteria. participants were detailed examination analysis hospitalization monitored. Results: Out total 60 DM DKA studied, 53.3% belonged 51...
Introduction India has experienced seven outbreaks of the Nipah virus (NiV) since 2001, primarily occurring in southern and eastern regions country. The region been main site for these outbreaks. In contrast, region, which borders Bangladesh, not reported any 2007. However, Bangladesh continues to experience nearly annual outbreaks, indicating a significant lack surveillance that area. To improve country’s preparedness gather support enhancing public health northeastern states near area...
Acute coronary syndrome (ACS) refers to a group of conditions that include ST-elevation myocardial infarction (STEMI), non-ST elevation (NSTEMI) and unstable angina. Therefore, it is interest assess the risk factor (R/F) ACS. 67 patients underwent investigation with help history clinical examination test like electrocardiogram (ECG), blood sugar lipid level. Data shows R/F was seen more for males than females 30-40 years age range. Thus, we conclude that, multiple complications chest pain...
Background: Undoubtedly, stroke is an important public health problem as well precursor of mortality and morbidity. It also leads to loss disability adjusted life years it causes long term severe disability. The objective this study was association lipoprotein (a) in ischemic patients with matched controls.Methods: This a prospective case controlled study. group includes 100 consecutive admitted medicine/neurology departments our hospital, 50 control for nonvascular diseases. ethical...
Background: Complications like arrhythmias, cardiac failure, cerebrovascular and mechanical complications. Among these complications, arrhythmias are the most common complication of acute myocardial infarction. The objective this study was to risk factors various in patients with coronary heart disease.Methods: Present a hospital based cross sectional conducted at department General Medicine tertiary care for period two years among 102 patients. Detailed history, clinical examination,...
Background: Type 2 Diabetes Mellitus (DM) is a non-communicable disease. DM produces damage in small blood vessels characterized by morphologic and biochemical alterations of the capillary basal lamina. These abnormalities have been observed several organs including lung. As prevalence diabetes rapidly increasing, it would be important to study pulmonary functions this sub group.Methods: The present observational carried out at medicine department. It includes previously diagnosed type...
Background: Studies reveal that the average age of stroke in less developed nations would be younger due to changing population structures brought on by increased mortality rates and other causes death. The risk death for AS patients is highest first few weeks varies from 20 50% month, depending age, severity stroke, medical disorders, treatment effectiveness all outcomes. Furthermore, Tn subunits bind muscle filaments, according studies. Since it a sensitive sign myocardial necrosis,...
The magnitude and duration of immune response to COVID-19 vaccination in older adults are known be adversely affected due immunosenescence inflammaging. threat emerging variants warrants studies on primary booster doses so as understand the effectiveness vaccines countering variants. Non-human primates (NHPs) ideal translational models, immunological responses NHPs similar those humans, it enables us host vaccine. We initially studied humoral aged rhesus macaques employing a three-dose...
Background: The present study was undertaken to analyse the clinical profile of type 2 diabetes patients presenting with diabetic ketoacidosis at time presentation, owing dearth scientific enquiry into this research query. Methods: an analytical, cross-sectional conducted over period two years. All admitted during constituted population, after being subjected prefixed selection criteria. Detailed history recorded and thorough physical examination all participants, along basic relevant blood...