A5062110068- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Extracellular vesicles in disease
- Vibrio bacteria research studies
- Viral Infections and Outbreaks Research
- Studies on Chitinases and Chitosanases
- Cholinesterase and Neurodegenerative Diseases
- HIV/AIDS Research and Interventions
- Immune responses and vaccinations
- Vector-borne infectious diseases
- Leptospirosis research and findings
- COVID-19 Impact on Reproduction
- Virology and Viral Diseases
- Alzheimer's disease research and treatments
- Telomeres, Telomerase, and Senescence
- Pneumocystis jirovecii pneumonia detection and treatment
- Dengue and Mosquito Control Research
- Parvovirus B19 Infection Studies
- Neuroscience and Neuropharmacology Research
- Dermatological and COVID-19 studies
- COVID-19 Clinical Research Studies
Liverpool School of Tropical Medicine
2022
ICMR-National Institute of Virology
2011
City University of New York
2010
The Ohio State University
2007
Cleveland Clinic
2000
An intrafamilial outbreak in West Bengal, India, involving 5 deaths and person-to-person transmission was attributed to Nipah virus. Full-genome sequence of virus (18,252 nt) amplified from lung tissue showed 99.2% nt 99.8% aa identity with the Bangladesh-2004 isolate, suggesting a common source
Intracellular aggregation of the microtubule-associated protein tau into filamentous inclusions is a defining characteristic Alzheimer disease. Because appearance tau-aggregate bearing lesions correlates with both cognitive decline and neurodegeneration, it has been hypothesized that may be directly toxic to cells harbor them. Testing this hypothesis in cell culture complicated by resistance full-length isoforms over experimentally tractable time periods. To overcome limitation,...
Universal coverage of vaccines alone cannot be relied upon to protect at-risk populations in lower- and middle-income countries against the impact coronavirus disease 2019 (COVID-19) pandemic newer variants. Live vaccines, including Bacillus Calmette–Guérin (BCG), are being studied for their effectiveness reducing incidence severity COVID-19 infection. In this multi-centre quadruple-blind, parallel assignment randomised control trial, 495 high-risk group adults (aged 18–60 years) were into...
Background . Dengue viruses (DV) belong to the family Flaviviridae, with four serotypes referred as DV-1, DV-2, DV-3, and DV-4. A large-scale outbreak of dengue fever occurred in 2012 involving several districts West Bengal. Objective To present a comprehensive picture identify prevailing serotypes. Materials Methods Serum samples were collected from suspected cases. Samples cases <5 days duration tested for NS1 antigen employing Pan Bio (Australia) ELISA kit. ≥5 dengue-specific IgM by...
Deletion of the human SHANK3 gene near terminus chromosome 22q is associated with Phelan–McDermid syndrome and autism spectrum disorders. Nearly all such deletions also span tightly linked IB2 gene. We show here that protein broadly expressed in brain highly enriched within postsynaptic densities. Experimental disruption mice reduces AMPA enhances NMDA receptor-mediated glutamatergic transmission cerebellum, changes morphology Purkinje cell dendritic arbors, induces motor cognitive deficits...
Japanese encephalitis (JE) is the most important cause of acute and epidemic viral encephalitis. Every year sporadic JE cases are reported from various districts West Bengal, indicating its endemicity in this state. vaccination programme has been undertaken by State Health Department Bengal. This study was aimed at seeing present scenario among syndrome (AES) Bengal.Blood and/or CSF samples were referred suspected AES to referral virology laboratory Calcutta School Tropical Medicine...
Acute encephalitis syndrome (AES) surveillance in India has indicated that Japanese virus (JEV) accounts for 5-35% of AES cases annually; the etiology remains unknown remaining cases. We implemented comprehensive to identify other etiological agents AES, with emphasis on dengue virus.Serum and cerebrospinal fluid (CSF) specimens were collected from patients enrolled prospectively 2014-2017 at selected sites three high burden states India. All samples initially tested JEV IgM. Specimens...
CD4+ T lymphocyte counts are the most important indicator of disease progression and success antiretroviral treatment in HIV infection resource limited settings. The nationwide reference range lymphocytes was not available India. This study conducted to determine values absolute cell percentages for adult Indian population.
The lncRNA NEAT1 plays a vital role in mitochondrial function and antiviral response. We have previously identified as dysregulated lncRNAs found an inverse correlation with interferon alpha-inducible protein 27 (IFI27) expression associated developing dengue severity. However, the of virus (DV) infection remains elusive. Here, we undertook study to evaluate functional consequences IFI27 modulation on response viral replication infection. observed that knockdown augmented via RIG-I pathway....
The circulating microRNA (miRNA) profile has been widely used for identifying potential biomarkers against viral infections. However, data on expression patterns in dengue patients are scanty. Considering the impact of severity caused by infection, miRNA profiles plasma may prove to be valuable developing early prognostic markers disease severity. Here, we described an in-depth analytical study small RNA sequencing obtained from 39 patients. Integrating bioinformatics and
ABSTRACT Extracellular vesicles (EVs) are small membrane secreted into biological fluids, which play crucial roles in influencing the cellular function different pathological processes. However, there is less clarity on how plasma EVs influence proliferation activation and functions of immune cells during dengue virus (DV) infection. In this study, we aimed to characterize circulating from categories patients examined consequence naïve CD4+ T isolated mild or severe patients. We observed...
Hepatitis B virus (HBV) and HIV co-infection has variable prevalence worldwide. In comparison to HBV mono-infection, the course of chronic infection is accelerated in HIV/HBV co-infected patients. present study was carried out analyse baseline characteristics (clinical, biochemical, serological virological) treatment naïve mono-infected patients.Between July 2011 January 2013, a total number 1331 HIV-seropositive individuals, enrolled ART Centre Calcutta School Tropical Medicine, Kolkata,...
Cases of meningoencephalitis with no known etiology remain a major challenge to clinical management brain infections across the world. In this study, we detected and characterized whole-genome primate erythroparvovirus 1 (B19V) in cases India.
Background: An unusual outbreak of acute encephalitis syndrome (AES) with high case fatality was reported from Kaliachak- I, II and III Blocks Malda District West Bengal in the month June 2014 affecting 72 children 34 deaths. The purpose this study to investigate light epidemiological as well etiological determinants. Methods: investigating team collected clinical data cases admitted at Medical College Kaliachak BPHC. Different samples, (serum, CSF etc) control population were screened for...
Background. Hepatitis B and HIV infections are serious global public health problems. Many of the countries with high burden also affected by prevalence hepatitis infection, leading to frequent HIV/HBV coinfection. Seroprevalence study is important assess magnitude dynamics disease transmission decide prevention control strategy. There limited data seroprevalence co-infection in West-Bengal, India. Objective. To determine HBsAg (hepatitis surface antigen) positivity among infected...
Background: Combination of tenofovir disoproxil fumarate (TDF), lamivudine (3TC) and efavirenz (EFV) is preferred in the treatment HIV/hepatitis B virus (HBV) coinfection. We postulated that a HBV active nucleoside reverse transcriptase (RT) inhibitor/nucleotide RT inhibitor backbone adefovir dipivoxil (ADV) +3TC would be as effective TDF for Indian population. Objective: ADV + 3TC could an alternative option these HIV/HBV coinfected individuals, preserving dually second-line following...
After its first appearance in Kolkata (Calcutta) during 1963-1965, chikungunya occurred epidemic form India 17 states and union territories. There were 13,90,322 cases suspected to be suffering from 2006, 59,535 2007 11,222 2008; 2008 there 15,961, 7,837 262 samples, respectively, sent the National Institute of Virology, Pune, Communicable Disease, Delhi, for serological diagnosis. Of these, 2001, 1826 44, confirmed as chikungunya. no deaths (data Vector Borne Disease Control Programme,...
Extracellular vesicles (EVs) emerged as critical contributors to the pathogenesis of vascular endothelial barrier dysfunction during inflammatory response infection. However, contribution circulating EVs modifying function dengue virus infection remains unclear. In this study, we showed that severe patients' plasma-derived EV (SD-EV) were found carry elevated levels different protein cargos, e.g., immunoregulatory proteins (PD-L1, CD44). Further, demonstrated SD-EV induces PD-1 and CD44...
Methods Between July 2011 and January 2013, a total number of 1331 HIV-seropositive treatment naive individuals, enrolled in the ART Centre Calcutta School Tropical Medicine were screened for HBsAg. A 1253 HIV mono-infected 78 HIV/HBV co-infected patients characterized. The evaluated HBeAg anti HBe antibody by ELISA. HBV DNA was detected nested PCR amplification followed genotype determination.