A5050297443- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Spinal Hematomas and Complications
- Cervical and Thoracic Myelopathy
- Anesthesia and Pain Management
- Pelvic and Acetabular Injuries
- HIV Research and Treatment
- Spinal Dysraphism and Malformations
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Hip and Femur Fractures
- Ocular Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Immune Cell Function and Interaction
- Clinical practice guidelines implementation
- HIV/AIDS Research and Interventions
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Pregnancy-related medical research
- Patient-Provider Communication in Healthcare
- Congenital Diaphragmatic Hernia Studies
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Hepatitis C virus research
University of Virginia
2015-2024
University of Virginia Health System
2014-2023
Johns Hopkins Hospital
2016
University of Virginia Medical Center
2015
Shriners Hospitals for Children - Philadelphia
2013
Wayne State University
2006-2012
Post Graduate Institute of Medical Education and Research
2008-2012
Kresge Eye Institute
2012
ABSTRACT Staphylococcus aureus is a leading cause of severe endophthalmitis, which often results in vision loss some patients. Previously, we showed that Toll-like receptor 2 (TLR2) ligand pretreatment prevented the development staphylococcal endophthalmitis mice and suggested microglia might be involved this protective effect (Kumar A, Singh CN, Glybina IV, Mahmoud TH, Yu FS. J. Infect. Dis. 201:255–263, 2010). The aim present study was to understand how microglial innate response modulated...
Study Design. Retrospective database review. Objective. The aim of this study was to determine how both morbid obesity (body mass index [BMI] ≥40) and (BMI 30–39.9) modify 90-day complication rates 30-day readmission following 1- 2-level, primary, lumbar spinal fusion surgery for degenerative pathology in an elderly population. Summary Background Data. In the United States, obese patients are known have increased risk complication, yet demographics increasingly undergoing elective spine...
Back pain in adolescents is very common and often seen the office for evaluation of potential spinal pathology. Pediatric back has thought to be from serious identifiable causes such as spondylolysis, spondylolisthesis, tumor, or infection. A follow-up analysis initially presenting with their eventual subsequent diagnosis within 1 year not been reported on a large scale national sample.A insurance database (PearlDiver Patient Records Database) was queried ICD-9 codes identify patients aged...
Study Design. Retrospective database review. Objective. To determine the 90-day complication rate and 1-year mortality in patients 80 years of age older who were treated with posterolateral lumbar spinal fusion surgery to compare these rates against those elderly ages 65 79. Summary Background Data. Patients over specifically represent a substantial proportion US population, 11 million such individuals 2010. Few studies have comprehensively assessed morbidity associated than years. Methods....
Study Design. Retrospective database review. Objective. To determine readmission rates after 1 to 2 level, primary, elective lumbar spinal fusion surgery for degenerative pathology and elucidate risk factors that predict increased of 30-day Summary Background Data. Early postoperative readmissions spine represent a significant source cost morbidity. As the elderly population represents demographic with growing need surgery, within this are interest. Methods. Medicare data (2005–2012) from an...
CD4+ T lymphocyte counts are the most important indicator of disease progression and success antiretroviral treatment in HIV infection resource limited settings. The nationwide reference range lymphocytes was not available India. This study conducted to determine values absolute cell percentages for adult Indian population.
OBJECTIVE Lumbar epidural steroid injections (LESIs) are performed for both diagnostic and therapeutic purposes a variety of indications, including low-back pain, the leading cause disability expense due to work-related conditions in US. The agent used is reported relieve nerve root inflammation, local ischemia, resultant but injection may also have an adverse impact on spinal surgery thereafter. In particular, possibility that preoperative increase risk surgical site infection after lumbar...
This international, randomized, double-blind trial (NCT01864174) compared the efficacy and safety of metformin extended-release (XR) immediate-release (IR) in patients with type 2 diabetes. After a 4-week placebo lead-in, pharmacotherapy-naïve adults glycated haemoglobin (HbA1c) at 7.0% to 9.2% were randomized (1:1) receive once-daily XR 2000 mg or twice-daily IR 1000 for 24 weeks. The primary endpoint was change HbA1c after Secondary endpoints fasting plasma glucose (FPG), mean daily (MDG)...
Study Design. A retrospective database analysis. Objective. The aim of this study is to compare rates postoperative dysphagia, length stay, infection, and wound complications following short long anterior cervical discectomy fusion (ACDF) in patients who received local intraoperative steroids those did not. Summary Background Data. Only one prior small institutional has investigated the application at time ACDF decrease dysphagia. Methods. large administrative was utilized infectious within...
Study Design. Retrospective database review. Objective. To compare complication and reoperation rates after anterior cervical discectomy fusion (ACDF), posterior (PCFs), corpectomy (ACCF) for spondylotic myelopathy (CSM) using a large national of Medicare beneficiaries. Summary Background Data. CSM is the most common cause in patients over 55 years considered spinal cord dysfunction world. Surgical treatment includes ACDF, PCF, or ACCF procedures. Methods. The PearlDiver (2005–2012) was...
Study Design. A retrospective database review. Objective. The aim of this study was to determine the complication and mortality rates in patients 80 years age older who were treated with anterior cervical fusion surgery compare these against those other elderly patients. Summary Background Data. Cervical spondylosis is frequently observed most common cause myelopathy adults. With increasing life expectancies, a greater proportion are being spine at later age. Limited information available...
Study Design. A retrospective database analysis among Medicare beneficiaries Objective. The aim of this study was to determine the effect chronic steroid use and methicillin-resistant Staphylococcus aureus (MRSA) infection on rates surgical site (SSI) mortality in patients 65 years age older who were treated with lumbar spine fusion. Summary Background Data. Systemic immunosuppression focus elsewhere body are considered risk factors for SSI. Chronic previous MRSA have been associated an...
ABSTRACT We genotyped the RT and PI regions of pol gene HIV-1 from treatment-naive infected individuals in North India evaluated their possible physiological relevance association with drug resistance. Plasma samples 52 newly diagnosed HIV-1-infected drug-naive were subjected to CD4(+) cell count plasma viral load. For genotyping, protease amplified cDNA reverse transcribed RNA by single or nested polymerase chain reaction (PCR). Sequences products analyzed for mutations using Stanford DR...
In Brief Study Design. A retrospective analysis of a prospectively collected multicenter database. Objective. To identify the radiographical and clinical outcomes in Lenke 3 curves fused selectively (S) versus nonselectively (NS). Summary Background Data. Surgical treatment options for include fusion both (NS) or selective thoracic curve (S). Selective spares lumbar motion segments; however, it may result marked residual deformity. Methods. database was retrospectively reviewed adolescent...
Purpose Congenital malformations of the bony vertebral column are often accompanied by spinal cord anomalies; these observations have been reinforced with use magnetic resonance imaging (MRI). We hypothesized that incidence anomalies will increase as number and complexity abnormalities increases. Methods All patients aged ≤13 years ( n = 75) presenting to pediatric spine clinic from 2003−2013 congenital deformity both radiographs MRI were analyzed retrospectively for bone neural pathology....