A5031060251- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Diabetes Management and Research
- Pharmacology and Obesity Treatment
- Cannabis and Cannabinoid Research
- Neuroendocrine Tumor Research Advances
- Genetics and Neurodevelopmental Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adrenal Hormones and Disorders
- Pancreatic and Hepatic Oncology Research
- Oral Health Pathology and Treatment
- Oral microbiology and periodontitis research
- Cardiovascular Function and Risk Factors
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Peptidase Inhibition and Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Colorectal Cancer Treatments and Studies
- Dental Health and Care Utilization
- Coronary Interventions and Diagnostics
Institut d'Investigació Biomédica de Bellvitge
2016-2025
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2016-2025
Instituto de Salud Carlos III
2021-2025
Universitat de Barcelona
2014-2024
Bellvitge University Hospital
2009-2023
Centro de Investigación Biomédica en Red
2012-2023
Ajuntament de L’Hospitalet
2014-2019
Fukushima Medical University
2016
National Institutes of Health
2016
University of Pittsburgh
2016
Abstract Background Diabetes and periodontitis are chronic non‐communicable diseases independently associated with mortality have a bidirectional relationship. Aims To update the evidence for their epidemiological mechanistic associations re‐examine impact of effective periodontal therapy upon metabolic control (glycated haemoglobin, HbA1C). Epidemiology There is strong that people elevated risk dysglycaemia insulin resistance. Cohort studies among diabetes demonstrate significantly higher...
We studied the effects of hyperglycemia on β-cell death and mass in syngeneically transplanted islets. Six groups STZ-induced diabetic C57BL/6 mice were with 100 syngeneic islets, an insufficient to restore normoglycemia. Groups 1, 2, 3 remained hyperglycemic throughout study. 4, 5, 6 treated insulin from day 7 before transplantation 10 after transplantation. After discontinuation, group achieved definitive Grafts harvested at (groups 1 4), 2 5), 30 6) days On 3, initially (0.13 ± 0.01 mg)...
Efficacy and safety of the glucagon-like peptide 1 (GLP-1) analog oral semaglutide sodium-glucose cotransporter 2 inhibitor empagliflozin were compared in patients with type diabetes uncontrolled on metformin.Patients randomized to once-daily open-label treatment 14 mg (n = 412) or 25 410) a 52-week trial. Key end points change from baseline week 26 HbA1c (primary) body weight (confirmatory secondary). Two estimands addressed efficacy-related questions: policy (regardless trial product...
Aim: The aim of this study was to compare the efficacy and safety once-daily human glucagon-like peptide-1 analogue liraglutide with dipeptidyl peptidase-4 inhibitor sitagliptin, each added metformin, over 52 weeks in individuals type 2 diabetes. Methods: In an open-label, parallel-group trial, metformin-treated participants were randomised 1.2 mg/day (n = 225), 1.8 221) or sitagliptin 100 219) for 26 (main phase). Participants continued same treatment a 26-week extension. Results:...
We determined the beta-cell replicative rate, apoptosis, cross-sectional area, and pancreatic mass throughout entire postweaning lifespan (months 1, 3, 7, 10, 15, 20) of Lewis rats. Beta-cell replication was progressively reduced in initial months life but remained stable after month 7 (month 0.99 +/- 0.10%; 0.24 0.04%; 0.12 0.02%; 0.14 0.10 0.03%; 20, 0.13 analysis variance [ANOVA], P < 0.001). apoptosis low did not change significantly from 1 to 20 life. Cross-sectional area...
OBJECTIVE To evaluate efficacy and safety of switching from twice-daily exenatide to once-daily liraglutide or 40 weeks continuous therapy. RESEARCH DESIGN AND METHODS When added oral antidiabetes drugs in a 26-week randomized trial (Liraglutide Effect Action Diabetes [LEAD]-6), more effectively improved A1C, fasting plasma glucose, the homeostasis model β-cell function (HOMA-B) than exenatide, with less persistent nausea hypoglycemia. In this 14-week extension LEAD-6, patients switched 10...
Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target Spanish population. In total 5072 people older than 18 years,were randomly selected all over Spain). Socio-demographic and clinical data, survey on habits (physical activity food consumption) weight, height, waist, hip blood pressure were recorder. A fasting draw an oral glucose tolerance test performed. Determinations serum made. follow-up same...
At the time first pancreas transplant was performed by Kelly and Lillehei in 1966, insulin therapy for diabetes generally available but administered a form that is known today as “conventional therapy.”1 In this era, many half of all juvenile onset diabetics did not reach age 55 years. Early mortality from accelerated cardiovascular disease, renal failure, hypoglycemia-related events were commonplace. The early low success rate transplantation comparison also suboptimal. As will be...
Pancreatic β-cell dysfunction is a key feature of type 2 diabetes, and novel regulators insulin secretion are desirable. Here we report that the succinate receptor (SUCNR1) expressed in β-cells up-regulated hyperglycemic states mice humans. We found acts as hormone-like metabolite stimulates via SUCNR1-Gq-PKC-dependent mechanism human β-cells. Mice with β-cell-specific Sucnr1 deficiency exhibit impaired glucose tolerance on high-fat diet, indicating SUCNR1 essential for preserving...
OBJECTIVE To assess the efficacy and safety of switching from sitagliptin to liraglutide in metformin-treated adults with type 2 diabetes. RESEARCH DESIGN AND METHODS In an open-label trial, participants randomized receive either (1.2 or 1.8 mg/day) (100 mg/day), each added metformin, continued treatment for 52 weeks. a 26-week extension, sitagliptin-treated were randomly allocated instead at 1.2 mg/day, while originally unchanged. RESULTS Although weeks changed glycosylated hemoglobin...
Abstract Background and Objective Use of self‐reported questionnaires in Dentistry may be useful to estimate the prevalence periodontitis epidemiological studies. This study aims assess accuracy self‐reporting for predicting a Spanish population participating diabetes incidence study. Materials Methods Data were collected from 231 patients Di@bet.es Eight questions about periodontal health included patient‐reported questionnaire. The outcomes validated against full‐mouth examination....
Abstract Aims To evaluate the efficacy and safety of oral semaglutide versus comparators by patient characteristic subgroups in patients with type 2 diabetes. Materials Methods Change from baseline glycated haemoglobin (HbA1c) body weight, achievement HbA1c <7.0% 7 mg, 14 flexibly dosed (flex) were assessed across (age, race, ethnicity, diabetes duration, mass index HbA1c) PIONEER programme. Treatment differences analysed using a mixed model for repeated measurements continuous variables...
Islets are particularly vulnerable in the initial days after transplantation when cell death results loss of more than half transplanted islet tissue. To determine whether a non-specific inflammation at grafted site mediated by local expression inflammatory cytokines could play role on damage to islets, we studied expressions interleukin-1β (IL-1β) and inducible form nitric oxide synthase (iNOS) syngeneic transplantation. Insulin-treated streptozotocin-diabetic Lewis rats were syngeneically...
Background & Aims: Epithelial tumors generally resemble the cellular architecture of their tissue origin. However, this link remains largely unexplored in pancreas. Methods: Using Nanostring GeoMx DSP®, Resolve Molecular Cartography® and CosMx®, integration with single cell RNAseq datasets, we mapped human pancreatic ductal epithelium non-neoplastic pancreas, compared it to cancer subtypes. Results: Groups Keratin-5 + cells among Pan-Cytokeratin duct have a gene signature reminiscent...
Abstract Type 2 diabetes (T2D) is becoming one of the leading health problems in Western societies, diminishing quality life and consuming a significant share healthcare resources. This study presents machine learning models for T2D diagnosis prognosis, developed using heterogeneous data from Spanish population dataset (Di@bet.es study). The were trained exclusively on individuals classified as controls undiagnosed diabetics, ensuring that results are not influenced by treatment effects or...