A5069422301- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Nutrition, Genetics, and Disease
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
Vrije Universiteit Brussel
2020-2023
Molecular Oncology (United States)
2021
Bio-Medical Science (South Korea)
2019
Medisch Spectrum Twente
2010
Medical University of Vienna
2010
Radboud University Medical Center
2010
Case Western Reserve University
2010
Case Comprehensive Cancer Center
2010
University School
2010
Radboud University Nijmegen
2010
Abstract Maintenance of the pancreatic acinar cell phenotype suppresses tumor formation. Hence, repetitive acute or chronic pancreatitis, stress conditions in which cells dedifferentiate, predispose for cancer formation pancreas. Dedifferentiated acquire a large panel duct cell-specific markers. However, it remains unclear to what extent dedifferentiated acini differ from native and genes are uniquely regulating dedifferentiation. Moreover, most studies have been performed on mice since...
Background & Aims: Epithelial tumors generally resemble the cellular architecture of their tissue origin. However, this link remains largely unexplored in pancreas. Methods: Using Nanostring GeoMx DSP®, Resolve Molecular Cartography® and CosMx®, integration with single cell RNAseq datasets, we mapped human pancreatic ductal epithelium non-neoplastic pancreas, compared it to cancer subtypes. Results: Groups Keratin-5 + cells among Pan-Cytokeratin duct have a gene signature reminiscent...
Abstract A ‘classical’ and a ‘basal‐like’ subtype of pancreatic cancer have been reported, with differential expression GATA6 different dosages mutant KRAS . We established in situ detection point mutations mRNA panels for the consensus subtypes aiming to project these findings paraffin‐embedded clinical tumour samples spatial quantitative analysis. unveiled that, next inter‐patient intra‐patient inter‐ductal heterogeneity, intraductal phenotypes exist anti‐correlating levels G12D The...
ABSTRACT Maintenance of the pancreatic acinar cell phenotype suppresses tumor formation. Hence, repetitive acute or chronic pancreatitis, stress conditions in which cells dedifferentiate, predispose for cancer formation pancreas. Dedifferentiated acquire a large panel duct cell-specific markers. However, it remains unclear to what extent dedifferentiated acini differ from native and genes are uniquely regulating dedifferentiation. Moreover, most studies have been performed mice since...