A5091982381- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- Cardiac Structural Anomalies and Repair
- Metabolism, Diabetes, and Cancer
- Protease and Inhibitor Mechanisms
- Pancreatitis Pathology and Treatment
- Cancer Research and Treatments
- Esophageal and GI Pathology
- Renal and related cancers
Université Libre de Bruxelles
2023-2024
Pancreatic ductal adenocarcinoma (PDAC) represents a formidable challenge due to its aggressive nature and poor prognosis. The tumor microenvironment (TME) in PDAC, characterized by intense stromal desmoplastic reactions dominant presence of cancer-associated fibroblasts (CAFs), significantly contributes therapeutic resistance. However, within the heterogeneous CAF population, fibroblast activation protein (FAP) emerges as promising target for Gallium-68 FAP inhibitor positron emission...
Background & Aims: Epithelial tumors generally resemble the cellular architecture of their tissue origin. However, this link remains largely unexplored in pancreas. Methods: Using Nanostring GeoMx DSP®, Resolve Molecular Cartography® and CosMx®, integration with single cell RNAseq datasets, we mapped human pancreatic ductal epithelium non-neoplastic pancreas, compared it to cancer subtypes. Results: Groups Keratin-5 + cells among Pan-Cytokeratin duct have a gene signature reminiscent...
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with poor prognosis. Gemcitabine the first-line therapy for PDAC, but gemcitabine resistance major impediment to achieving satisfactory clinical outcomes. This study investigated whether methylglyoxal (MG), an oncometabolite spontaneously formed as by-product of glycolysis, notably favors PDAC gemcitabine. We observed that human tumors expressing elevated levels glycolytic enzymes together high glyoxalase 1 (GLO1), MG-detoxifying...
The most frequently invaded margins on pancreatoduodenectomy specimens for pancreatic ductal adenocarcinoma are vascular margins, particularly the superior mesenteric artery (or mesopancreatic) margin. Due to limited exploration of radiological aspect mesopancreas, aim this study was evaluate mesopancreatic infiltration through imaging patients with who underwent pancreatoduodenectomy, correlate these findings histopathology and their impact survival.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest tumors with slow progress in systemic therapies due to its peculiar and resistant tumor microenvironment. Inclusion isotoxic high-dose stereotactic body radiation therapy (iHD-SBRT) into a total neoadjuvant strategy (TNT) is promising for treatment localized PDAC. However, histo-molecular effects iHD-SBRT are still poorly explored. In this study, we have shown that TNT, associating FOLFIRINOX [FFX] followed by iHD-SBRT,...
Abstract INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest tumors. Unlike other tumors, progress systemic therapies has been very slow, mainly due to peculiar and resistant tumor microenvironment (TME) PDAC. The addition ablative stereotactic body radiation therapy (SBRT) in a total neoadjuvant strategy is promising for treatment localized PDAC currently being explored several clinical trials. However, if possesses ability modulate TME, impact high-dose SBRT...