A5025916559- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Biliary and Gastrointestinal Fistulas
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Adenosine and Purinergic Signaling
- Cardiac, Anesthesia and Surgical Outcomes
- Liver physiology and pathology
- Cancer Mechanisms and Therapy
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Hernia repair and management
- interferon and immune responses
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sports injuries and prevention
- Urological Disorders and Treatments
- Immunotherapy and Immune Responses
- Artificial Intelligence in Healthcare and Education
- Radiomics and Machine Learning in Medical Imaging
- Soft tissue tumors and treatment
- Cardiac Valve Diseases and Treatments
Universitair Ziekenhuis Brussel
2021-2025
Vrije Universiteit Brussel
2021-2025
Europe Hospitals
2020-2025
Institut Pasteur du Maroc
2025
Mathys (Netherlands)
2024
The Japanese Society of Gastroenterological Surgery
2024
Iwate Medical University
2024
Onomichi General Hospital
2024
Hiroshima University
2024
Centre Hospitalier de l’Université de Montréal
2017-2023
Abstract The ectonucleotidases CD39 and CD73 catalyze extracellular ATP to immunosuppressive adenosine, as such, represent potential cancer targets. We investigated biological impacts of in pancreatic ductal adenocarcinoma (PDAC) by studying clinical samples experimental mouse tumors. Stromal tumoral expression significantly associated with worse survival human PDAC abolished the favorable prognostic impact presence tumor-infiltrating CD8+ T cells. In transplanted KPC tumors, both on myeloid...
Abstract Background and study aims Gastric outlet obstruction (GOO) is traditionally managed with surgical gastroenterostomy (surgical-GE) enteral stenting (ES). Endoscopic ultrasound-guided (EUS-GE) now a third option. Large studies assessing their relative risks benefits adequate follow-up are lacking. We conducted comparative analysis of patients who underwent EUS-GE, ES, or surgical-GE for GOO. Patients methods In this retrospective cohort study, consecutive presenting GOO at two...
The journal Artificial Intelligence Surgery was established to explore the integration of (AI) in surgery. It originated from desire understand potential true robotic surgery, as existing systems are tele-manipulators rather than autonomous robots. AI’s role surgery involves levels autonomy and a balance between human expertise technological advancements. In this regard, new field Surgiomics emerges, integrating patient data such genomics, radiomics, pathomics enhance surgical...
In this scoping review, we delve into the transformative potential of artificial intelligence (AI) in addressing challenges inherent whole-genome sequencing (WGS) analysis, with a specific focus on its implications oncology. Unveiling limitations existing technologies, review illuminates how AI-powered methods emerge as innovative solutions to surmount these obstacles. The evolution DNA progressing from Sanger next-generation sequencing, sets backdrop for AI’s emergence potent ally...
Following cardiac surgery, a great variety in intensive care unit (ICU) stay is observed, making it often difficult to adequately predict ICU preoperatively. Therefore, study was conducted investigate, which preoperative variables are independent risk factors for prolonged and whether patient's of experiencing an extended can be estimated from these predictors.The records 1566 consecutive adult patients who underwent surgery at our institution were analysed retrospectively over 2-year...
Immune checkpoint blockade has not yet been effective in patients with mismatch repair proficient metastatic colorectal cancer. Targeting immunosuppressive metabolic pathways is being explored as a new immunotherapeutic approach. We assessed whether CD73, the rate limiting enzyme that catalyzes degradation of extracellular AMP into adenosine, could be an immunological determinant liver metastases (CRLMs). By immunofluorescence on tissue microarrays, intratumoral CD73 expression (tCD73) was...
Background & Aims: Epithelial tumors generally resemble the cellular architecture of their tissue origin. However, this link remains largely unexplored in pancreas. Methods: Using Nanostring GeoMx DSP®, Resolve Molecular Cartography® and CosMx®, integration with single cell RNAseq datasets, we mapped human pancreatic ductal epithelium non-neoplastic pancreas, compared it to cancer subtypes. Results: Groups Keratin-5 + cells among Pan-Cytokeratin duct have a gene signature reminiscent...
Hepatic arterial infusion (HAI) chemotherapy, first introduced in the 1980s, has gained recognition as an effective locoregional treatment for colorectal liver metastasis (CRLM). Initially used unresectable metastases, HAI’s application expanded to adjuvant setting following hepatic resection, with early studies indicating improved disease-free survival. Recent research demonstrates that combining HAI modern systemic therapies enhances conversion resectability and prolongs both...
This editorial announces the need for a consensus conference on definitions of surgical nomenclature, which is evolving due to introduction non-human (hardware, software) devices and applications, including robotics. A recently created entity, Artificial Intelligence Organization Next Generation Surgeons (AIONS), comprised primarily AIS board members, has proposed updated following terms: surgery, endoluminal percutaneous robots, robotic-assisted surgery (RAS), remote artificial intelligence...
Risk stratification allows preoperative assessment of cardiac surgical risk faced by individual patients and permits retrospective analysis postoperative complications in the intensive care unit (ICU). The aim this single-center study was to investigate prediction extended ICU stay after surgery using both additive logistic model European System for Cardiac Operative Evaluation (EuroSCORE).A observational conducted. We collected clinical data 1562 consecutive undergoing over a 2-year period...
Abstract Background Finding a noninvasive radiomic surrogate of tumor immune features could help identify patients more likely to respond novel checkpoint inhibitors. Particularly, CD73 is an ectonucleotidase that catalyzes the breakdown extracellular AMP into immunosuppressive adenosine, which can be blocked by therapeutic antibodies. High expression in colorectal cancer liver metastasis (CRLM) resected with curative intent associated early recurrence and shorter patient survival. The aim...
In vitro models of human liver disease often fail to mimic the complex 3D structures and cellular organizations found in vivo. Precision cut slices (PCLS) retain physiological architecture native therefore could be an exceptional model. However, production PCLS induces a spontaneous culture-induced fibrogenic reaction, limiting application anti-fibrotic compounds. Our aim was improve cultures allow compound-induced fibrosis induction. Hepatotoxicity analyzed by lactate dehydrogenase leakage...
Soccer players frequently experience acute and chronic groin pain. Sportsman’s hernia is a common injury in professional soccer players, that causes inguinal The authors discuss their with the management of sportsman’s competing national international competition retrospective review prospectively collected data. Between March 2004 December 2009, seventy-one were surgically treated for hernia. Average age at surgery was 24 years, average duration symptoms from onset to surgical repair 11...
Abstract The lack of adequate human in vitro models that recapitulate the cellular composition and response liver to injury hampers development anti-fibrotic drugs. goal this study was develop a spheroid culture model fibrosis by using induced pluripotent stem cell (iPSC)-derived cells. iPSCs were independently differentiated towards hepatoblasts (iHepatoblasts), hepatic stellate cells (iHSCs), endothelial (iECs) macrophages (iMΦ), before assembly into free floating spheroids culturing...