A5061641235- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Bariatric Surgery and Outcomes
- Metabolism, Diabetes, and Cancer
- Thyroid Disorders and Treatments
- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Fatty Acid Research and Health
- Regulation of Appetite and Obesity
- Diabetes Management and Education
- Diet, Metabolism, and Disease
- Obesity, Physical Activity, Diet
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Hormonal and reproductive studies
- Chronic Disease Management Strategies
- Blood Pressure and Hypertension Studies
- Hemodynamic Monitoring and Therapy
- Pharmacology and Obesity Treatment
- Vitamin D Research Studies
Instituto de Investigación Biomédica de Málaga
2016-2025
Hospital Regional Universitario de Málaga
2016-2025
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2016-2025
Instituto de Salud Carlos III
2016-2025
Universidad de Málaga
2013-2023
Andalusian Centre for Nanomedicine and Biotechnology
2023
Centro de Investigación Biomédica en Red
2012-2021
Hospital Universitario Rey Juan Carlos
2009-2020
Hospital Universitari de Vic
2018
Hospital Clínic de Barcelona
2018
The Di@bet.es Study is the first national study in Spain to examine prevalence of diabetes and impaired glucose regulation. A population-based, cross-sectional, cluster sampling was carried out, with target population being entire Spanish population. Five thousand seventy-two participants 100 clusters (health centres or equivalent each region) were randomly selected a probability proportional size. Participation rate 55.8%. variables clinical demographic structured survey, lifestyle physical...
Prospective longitudinal studies evaluating the relevance of "Metabolically Healthy but Obese" (MHO) phenotype at risk for type 2 diabetes mellitus (T2D) and cardiovascular diseases are few results contradictory.As a representative general population, 1051 individuals were evaluated in 1997-1998 re-evaluated after 6 years 11 years. Subjects without known T2D given an oral glucose tolerance test. Anthropometric biochemical variables measured. Four sets criteria considered to define MHO...
Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target Spanish population. In total 5072 people older than 18 years,were randomly selected all over Spain). Socio-demographic and clinical data, survey on habits (physical activity food consumption) weight, height, waist, hip blood pressure were recorder. A fasting draw an oral glucose tolerance test performed. Determinations serum made. follow-up same...
The aim of this study was to define the incidence type 2 diabetes in a low-risk Caucasian population northern Spain and its association with various risk factors.The Asturias Study is prospective, population-based survey cardiovascular factors. baseline examination carried out during 1998-1999 when 1,034 individuals, aged 30-75 years, were randomly selected determine prevalence pre-diabetes Principality (northern Spain). In 2004-2005, these same subjects invited for follow-up examination;...
Low physical activity (PA), or sedentary lifestyle, is associated with the development of several chronic diseases. We aimed to investigate current prevalence sedentariness and its association diabetes other cardiovascular risk factors. PA was evaluated in a population-based, cross-sectional, randomly sampled study conducted 2009–2010 Spain. International Physical Activity Questionnaire (SF-IPAQ) used assess PA. 4991 individuals (median age 50 years, 57% women) were studied. Prevalence 32.3%...
Introduction A physically active life-style plays an independent role in the protection against type 2 diabetes and cardiovascular diseases. Irisin, a novel exercise-induced myokine, activates thermogenesis rodents through increasing beige fat cells abundance within white fat. We aimed to investigate circulating irisin levels association with degree of physical activity various metabolic parameters humans. Methods Circulating (ELISA) were analyzed 428 subjects (195 men/233 women)....
In the last years, epigenetic processes have emerged as a promising area of complex diseases research. DNA methylation measured in Long Interspersed Nucleotide Element 1 (LINE-1) sequences has been considered surrogate marker for global genome methylation. New findings suggested potential involvement mechanisms Type 2 diabetes (T2DM) crucial interface between effects genetic predisposition and environmental influences. Our study evaluated whether predicted increased risk from T2DM or other...
The aim of this study was to investigate the national prevalence thyroid dysfunction in Spain and its association with various clinical, environmental, demographic variables.The included 4554 subjects (42.4% men) a mean age 50 years (range 18-93 years), who were participants national, cross-sectional, population-based survey conducted 2009-2010. Data gathered clinical characteristics, physical examination, blood sampling. Thyrotropin, free thyroxine, triiodothyronine, peroxidase antibody...
Oleocanthal and oleacein are olive oil phenolic compounds with well known anti-inflammatory anti-oxidant properties. The main evidence, however, is provided by experimental studies. Few human studies have examined the health benefits of oils rich in these biophenols. Our aim was to assess properties oleocanthal extra virgin (EVOO), compared those common (OO), people prediabetes obesity.Randomised, double-blind, crossover trial done aged 40-65 years obesity (BMI 30-40 kg/m2) (HbA1c 5.7-6.4%)....
Abstract Background Few European studies have used an oral glucose tolerance test (OGTT) to examine the incidence of type 2 diabetes. We determined impaired fasting (IFG), (IGT) and diabetes in a population from southern Spain. Material methods A population‐based cohort study was undertaken Pizarra, Baseline data were recorded on age, sex, weight, height, waist hip circumferences, status for 1051 persons, whom 910 free (at‐risk sample). Of these, 714 completed 6‐year follow‐up study. Body...
Eur J Clin Invest 2011; 41 (11): 1202–1209 Background Different studies, mostly cross-sectional, have found an association between low levels of thyroid hormones, even within the normal range, and a greater body mass index. The aim this study was to determine function risk for obesity. Materials methods In population-based prospective study, measurements were made anthropometric parameters, hormone urinary iodine in cohort Pizarra Study (n = 937), repeated 6 years later 784). At second...
Scope Epigenetic processes may be affected by environmental factors. DNA methylation measured in LINE‐1 elements (LINE‐1, long interspersed nucleotide element‐1) correlates with methylation. Variations stearoyl CoA desaturase (SCD) activity (a key enzyme the fatty acid metabolism) involved various that can lead to diseases such as obesity. We evaluated whether changes diet after a nutritional intervention would associated and/or specific of SCD1 gene promoter. Methods and results Design:...
Background/Objectives: Although evidence suggests that miR-484 and several fruit components are involved in glucose metabolism insulin resistance metabolic pathways, the relationship between serum levels consumption relation to risk of Type 2 diabetes (T2DM) remains elusive. The aim this study was evaluate possible association intake frequency with T2DM Spanish adult population. Methods: 2234 subjects from Di@bet.es cohort without at baseline were studied. Socio-demographic, anthropometric...
Hypoglycemia is the most common adverse event associated with insulin treatment in diabetes. The consequences of hypoglycemia can be quite aversive and potentially life threatening. physical sequelae provide ample reason for patients to fear avoid episodes. For these reasons, our purpose this study was develop a new measure that explores specific (FH) adult type 1 diabetes examine its psychometric properties. instrument developed assess FH initially made up 20 items, which 18 were negative 2...
To analyze the reference range of thyroid-stimulating hormone (TSH) in different BMI categories and its impact on classification hypothyroidism.The study included 3,928 individuals free thyroid disease (without previous disease, no interfering medications, TSH <10 µUI/mL peroxidase antibodies [TPO Abs] <50 IU/mL) who participated a national, cross-sectional, population-based were representative adult population Spain. Data gathered clinical demographic characteristics, physical examination,...