A5064059952- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Fatty Acid Research and Health
- Diet and metabolism studies
- Gestational Diabetes Research and Management
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Bariatric Surgery and Outcomes
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Pregnancy and preeclampsia studies
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Lipid metabolism and disorders
- Regulation of Appetite and Obesity
- Nutrition, Genetics, and Disease
- Bone health and osteoporosis research
Instituto de Salud Carlos III
2015-2025
Hospital Clínico Universitario Virgen de la Victoria
2007-2025
Instituto de Investigación Biomédica de Málaga
2016-2025
Centro de Investigación Biomédica en Red
2008-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2013-2024
Andalusian Centre for Nanomedicine and Biotechnology
2023-2024
Centre Hospitalier Universitaire de Montpellier
2024
Universidad de Málaga
2012-2023
Robert Bosch (Germany)
2019
Hospital Regional Universitario de Málaga
2003-2016
Prospective longitudinal studies evaluating the relevance of "Metabolically Healthy but Obese" (MHO) phenotype at risk for type 2 diabetes mellitus (T2D) and cardiovascular diseases are few results contradictory.As a representative general population, 1051 individuals were evaluated in 1997-1998 re-evaluated after 6 years 11 years. Subjects without known T2D given an oral glucose tolerance test. Anthropometric biochemical variables measured. Four sets criteria considered to define MHO...
Background: Transsexual persons afford a very suitable model to study the effect of sex steroids on uric acid metabolism. Design:This was prospective evaluate levels and fractional excretion (FEUA) in cohort 69 healthy transsexual persons, 22 male-to-female transsexuals (MFTs) 47 female-to-male (FMTs).The subjects were studied at baseline 1 2 yr after starting cross-sex hormone treatment. Results:The higher MFT group.Compared with baseline, had fallen significantly therapy group risen FMT...
In the last years, epigenetic processes have emerged as a promising area of complex diseases research. DNA methylation measured in Long Interspersed Nucleotide Element 1 (LINE-1) sequences has been considered surrogate marker for global genome methylation. New findings suggested potential involvement mechanisms Type 2 diabetes (T2DM) crucial interface between effects genetic predisposition and environmental influences. Our study evaluated whether predicted increased risk from T2DM or other...
Metabolic syndrome (MetS) has been postulated to increase the risk for type 2 diabetes, cardiovascular disease and cancer. Adipose tissue (AT) plays an important role in metabolic homeostasis, AT dysfunction active diseases. MetS is closely related lifestyle environmental factors. Epigenetics emerged as interesting landscape evaluate possible interconnection between disease, since it can be modulated by factors status. The aim of this study was determine whether impact on global DNA...
Abstract Background Few European studies have used an oral glucose tolerance test (OGTT) to examine the incidence of type 2 diabetes. We determined impaired fasting (IFG), (IGT) and diabetes in a population from southern Spain. Material methods A population‐based cohort study was undertaken Pizarra, Baseline data were recorded on age, sex, weight, height, waist hip circumferences, status for 1051 persons, whom 910 free (at‐risk sample). Of these, 714 completed 6‐year follow‐up study. Body...
Eur J Clin Invest 2011; 41 (11): 1202–1209 Background Different studies, mostly cross-sectional, have found an association between low levels of thyroid hormones, even within the normal range, and a greater body mass index. The aim this study was to determine function risk for obesity. Materials methods In population-based prospective study, measurements were made anthropometric parameters, hormone urinary iodine in cohort Pizarra Study (n = 937), repeated 6 years later 784). At second...
Scope Epigenetic processes may be affected by environmental factors. DNA methylation measured in LINE‐1 elements (LINE‐1, long interspersed nucleotide element‐1) correlates with methylation. Variations stearoyl CoA desaturase (SCD) activity (a key enzyme the fatty acid metabolism) involved various that can lead to diseases such as obesity. We evaluated whether changes diet after a nutritional intervention would associated and/or specific of SCD1 gene promoter. Methods and results Design:...
Lack of vitamin D (VD) has been associated with colorectal cancer (CRC). VD anti-inflammatory effects and regulates several cellular pathways by means its receptor, including epigenetic modifications. Adipose tissue dysfunction related to low-grade inflammation, which is diseases like cancer. The aim this study was explore the relationship between serum 25-hydroxyvitamin (25(OH)D), adipose gene expression receptor (VDR), pro-inflammatory markers, factor DNA methyltransferase 3a (DNMT3A) as...
Summary The main objective was to evaluate the association between SNPs and haplotypes of FABP1-4 genes type 2 diabetes, as well its interaction with fat intake, in one general Spanish population. replicated a second population which HOMA index also evaluated. Methods 1217 unrelated individuals were selected from population-based study [Hortega study: 605 women; mean age 54 y; 7.8% diabetes]. replication included 805 subjects Segovia, neighboring region Spain (446 females; 52 10.3%...
Abstract Backgrounds Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which activation Wingless (Wnt) signaling pathway is a common mechanism for CRC initiation. The Wnt mainly regulated by antagonists, as secreted frizzled-related protein (SFRP) family. Indeed, SFRP2 proposed noninvasive biomarker diagnosis. Vitamin D also antagonizes cancers cells. Several studies showed that vitamin was able to alter...
Abstract Background Gestational diabetes mellitus (GDM) and type 2 (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry criteria. Methods In two independent pregnancy cohorts, EPIPREG ( n = 480) EPIDG 32), in peripheral blood leukocytes measured at gestational age of 28 ± 2. constructed an MRS based on CpG hits from published...