A5065777683- Gut microbiota and health
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Gastrointestinal motility and disorders
- Epigenetics and DNA Methylation
- Dietary Effects on Health
- Fatty Acid Research and Health
- Bariatric Surgery and Outcomes
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Genetic Associations and Epidemiology
- Clostridium difficile and Clostridium perfringens research
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Pancreatic function and diabetes
- Artificial Intelligence in Healthcare
- Rheumatoid Arthritis Research and Therapies
- Biochemical Analysis and Sensing Techniques
- HVDC Systems and Fault Protection
- Lipid metabolism and biosynthesis
- Immune cells in cancer
- Gastroesophageal reflux and treatments
Instituto de Investigación Biomédica de Málaga
2014-2024
Universidad de Málaga
2016-2024
Hospital Regional Universitario de Málaga
2008-2024
Andalusian Centre for Nanomedicine and Biotechnology
2024
Instituto de Salud Carlos III
2009-2021
Centro de Investigación Biomédica en Red
2019-2021
Hospital Clínico Universitario Virgen de la Victoria
2016-2020
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2009-2020
Sociedad Española de Endocrinología y Nutrición
2014-2016
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2009-2014
Alterations of gut microbiome have been proposed to play a role in metabolic disease, but the major determinants microbiota composition remain ill defined. Nutritional and sex hormone challenges, especially during early development, shown permanently alter adult female phenotype contribute disturbances. In this study, we implemented large-scale analyses fecal samples from groups rats sequentially subjected various obesogenic manipulations, including perturbations by means neonatal...
In the last years, epigenetic processes have emerged as a promising area of complex diseases research. DNA methylation measured in Long Interspersed Nucleotide Element 1 (LINE-1) sequences has been considered surrogate marker for global genome methylation. New findings suggested potential involvement mechanisms Type 2 diabetes (T2DM) crucial interface between effects genetic predisposition and environmental influences. Our study evaluated whether predicted increased risk from T2DM or other...
Scope Little is known about the changes that a very‐low‐calorie ketogenic diet (VLCKD) produces in gut microbiota or effect of synbiotics during diet. The aim this study to evaluate produced by VLCKD and synbiotic supplementation. Methods results A randomized, single‐blind, parallel‐design trial conducted 33 obese patients who follow weight‐loss program (PnK‐Method) include followed low‐calorie (LCD). Subjects are randomly allocated three groups: one supplemented with synbiotics, second...
Changes in the intestinal microbial community and some metabolic disturbances, including obesity type2 diabetes, are related. Glucagon-like peptide-1 (GLP-1) regulates glucose homeostasis. Microbiota have been linked to incretin secretion. Antibiotic use causes changes diversity composition. Our aim was evaluate relationship between microbiota GLP-1 A prospective case-control study with a Helicobacter pylori-positive patient model involving subjects under eradication therapy (omeprazole,...
Background H. pylori infection and eradication cause perturbations of the gut microbiome. The microbiota has been identified as a potential contributor to metabolic diseases. We evaluate whether these alterations in intestinal composition produced by its posterior with antibiotic treatment could be associated glucose homeostasis metabolically healthy subjects. Methods Forty adult patients infected 20 control subjects were recruited. evaluated before two months after (omeprazole,...
Scope Epigenetic processes may be affected by environmental factors. DNA methylation measured in LINE‐1 elements (LINE‐1, long interspersed nucleotide element‐1) correlates with methylation. Variations stearoyl CoA desaturase (SCD) activity (a key enzyme the fatty acid metabolism) involved various that can lead to diseases such as obesity. We evaluated whether changes diet after a nutritional intervention would associated and/or specific of SCD1 gene promoter. Methods and results Design:...
To analyze the intestinal microbiota of patients with rheumatoid arthritis (RA) and obesity a higher percentage fatty tissue.Nested case-control study 80 RA age sex-matched controls. Obesity was defined as body mass index ≥ 30, composition using dual-energy x-ray absorptiometry. The gut analyzed 16 S rRNA gene sequencing; bioinformatics analysis performed QIIME2 PICRUSt. Other variables included averaged 28-joint Disease Activity Score (DAS28-ESR), cytokines adipokines. Two multivariate were...
Eur J Clin Invest 2012; 42 (1): 79–85 Abstract Aim To evaluate the association between serum levels of testosterone, sex hormone‐binding globulin (SHBG) and calculated bioavailable testosterone (bioT), risk type 2 diabetes mellitus (T2D) in a prospective cohort from southern Spain (Pizarra study). Research design methods The study was performed Pizarra Cohort Study, started 1995 with follow‐up 11 years. Anthropometric metabolic variables were measured at baseline 6 years follow‐up. Total...
The elongase of long chain fatty acids family 6 (ELOVL6) is an enzyme that specifically catalyzes the elongation saturated and monounsaturated with 12, 14 16 carbons. ELOVL6 expressed in lipogenic tissues it regulated by sterol regulatory element binding protein 1 (SREBP-1).We investigated whether genetic variation associated insulin sensitivity a population from southern Spain.We undertook prospective, population-based study collecting phenotypic, metabolic, nutritional information....
Background: The gut microbiome plays an important role in the lipid metabolism. Antibiotic treatment causes changes intestinal microbiota. Our objective was to explore relationship between microbiota and level of plasma high density lipoprotein cholesterol (HDL) low (LDL). Methods: Prospective case-control study with Helicobacter pylori-positive patients undergoing eradication therapy omeprazole, clarithromycin, amoxicillin. Stool blood samples were obtained from 20 controls (H. pylori...
Background: Antibiotic therapy used to eradicate Helicobacter pylori has been associated with changes in plasma ghrelin and alterations the gut microbiota. On other hand, levels have related microbiota composition. Our aim was evaluate relationship between H. infected patients who received antibiotic treatment for its eradication. Methods: A prospective case-control study that included forty -positive eradication (omeprazole, clarithromycin, amoxicillin) twenty healthy antigen-negative...
Bariatric surgery is the only procedure to obtain and maintain weight loss in long term, although mechanisms driving these benefits are not completely understood. In last years, gut microbiota has emerged as one of drivers through its metabolites, especially secondary bile acids. current study, we have compared acid pool, well anthropometric biochemical parameters, patient with morbid obesity who underwent bariatric by two different techniques, namely Roux-en-Y gastric bypass (RYGB) or...
Abstract Stearoyl CoA Desaturase-1 (SCD) is considered as playing an important role in the explanation of obesity. The aim this study was to evaluate whether DNA methylation SCD gene promoter associated with metabolic improvement morbidly obese patients after bariatric surgery. included 120 subjects morbid obesity who underwent a laparoscopic Roux-en Y gastric by-pass (RYGB) and control group 30 similar body mass index (BMI) that found six months RYGB. Fasting blood samples were obtained...
Scope The serum fatty acid ( FA ) composition is influenced by dietary fat and the endogenous production of s. Stearoyl C o A desaturase 1 SCD 1) rate‐limiting enzyme catalyzing synthesis MUFA s from saturated Variations in activity have been associated with obesity, diabetes, or inflammation. We evaluated associations between genetic variation gene, activity, intake oil, obesity a population‐based prospective study southern S pain. Methods results collected phenotypic, metabolic,...