A5034237305- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Enterobacteriaceae and Cronobacter Research
- Genomics and Phylogenetic Studies
- Streptococcal Infections and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microscopic Colitis
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Ocular Infections and Treatments
- Bacterial biofilms and quorum sensing
- Bacterial Infections and Vaccines
- Immune Response and Inflammation
- Antimicrobial Resistance in Staphylococcus
- Insect symbiosis and bacterial influences
- Helicobacter pylori-related gastroenterology studies
- Actinomycetales infections and treatment
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Cystic Fibrosis Research Advances
- Invertebrate Immune Response Mechanisms
- Insect Resistance and Genetics
- Bacterial Genetics and Biotechnology
Northwestern University
2020-2023
Center for Biologics Evaluation and Research
2023
University of Michigan–Ann Arbor
2013-2018
Michigan United
2016-2017
Kresge Eye Institute
2011-2012
Wayne State University
2011-2012
Klebsiella pneumoniae strains have been divided into two major categories: classical K. pneumoniae, which are frequently multidrug-resistant and cause hospital-acquired infections in patients with impaired defenses, hypervirulent severe community-acquired disseminated normal hosts. Both types of may lead to bacteremia associated significant morbidity mortality. The relative burden these among bloodstream isolates within the United States is not well understood.
Abstract Klebsiella pneumoniae has been classified into two types, classical K. (cKP) and hypervirulent (hvKP). cKP isolates are highly diverse important causes of nosocomial infections; they include globally disseminated antibiotic-resistant clones. hvKP sensitive to most antibiotics but virulent, causing community-acquired infections in healthy individuals. The virulence phenotype is associated with pathogenicity loci responsible for siderophore hypermucoid capsule production. Recently,...
Clostridium difficile (C. difficile) is an anaerobic gram-positive pathogen that the leading cause of nosocomial bacterial infection globally. C. (CDI) typically occurs after ingestion infectious spores by a patient has been treated with broad-spectrum antibiotics. While CDI toxin-mediated disease, transmission and pathogenesis are dependent on ability to produce viable spores. These must become metabolically active (germinate) in order disease. spore germination when encounter bile salts...
Streptococcus pneumoniae (pneumococcus) has remained a persistent cause of invasive and mucosal disease in humans despite the widespread use antibiotics vaccines. The resilience this organism is due to its capacity for adaptation through uptake incorporation new genetic material from surrounding microbial community. DNA recombination controlled by tightly regulated quorum sensing system that triggered extracellular accumulation competence stimulating peptide (CSP). In study, we demonstrate...
ABSTRACT Staphylococcus aureus is a leading cause of severe endophthalmitis, which often results in vision loss some patients. Previously, we showed that Toll-like receptor 2 (TLR2) ligand pretreatment prevented the development staphylococcal endophthalmitis mice and suggested microglia might be involved this protective effect (Kumar A, Singh CN, Glybina IV, Mahmoud TH, Yu FS. J. Infect. Dis. 201:255–263, 2010). The aim present study was to understand how microglial innate response modulated...
All fully sequenced strains of Streptococcus pneumoniae (pneumococcus) contain a version the blp locus which is responsible for regulation and secretion variable repertoire pneumococcal bacteriocins called pneumocins their associated immunity proteins. Pneumocins mediate intra- interspecies competition in vitro have been shown to provide competitive advantage vivo. Pneumocin production stimulated by extracellular accumulation peptide pheromone, BlpC. Both BlpC functional are secreted out...
Clostridium difficile is a Gram-positive obligate anaerobe that forms spores in order to survive for long periods the unfavorable environment outside host. C. leading cause of nosocomial infectious diarrhea worldwide. infection (CDI) arises after patient treated with broad-spectrum antibiotics ingests spores. The first step pathogenesis metabolic reactivation dormant within gastrointestinal (GI) tract through process known as germination. In this work, we aim elucidate specific conditions...
is a common cause of difficult-to-treat infections due to its propensity express resistance many antibiotics. For example, carbapenem-resistant
Klebsiella pneumoniae is a leading cause of antibiotic-resistant-associated deaths in the world. Here, we report deposition 14 structures enzymes from both core and accessory genomes sequence type 23 (ST23) K1 hypervirulent K. pneumoniae.
Here, we report the complete genome sequence of Clostridium innocuum strain LC-LUMC-CI-001. As recently as 2018, C. was generally considered a benign gastrointestinal microorganism. This isolated from stool patient with recurrent Clostridioides difficile infection-like illnesses.
We report the complete genome sequence of Clostridium innocuum ATCC 14501, which was isolated in 1962 from an appendiceal abscess. At that time, strain designated C. innocuum, given its suspected lack virulence, but recent reports suggest is emerging pathogen.
Klebsiella pneumoniae is a Gram-negative bacterium that major cause of nosocomial infections worldwide. Here, we present the complete genome sequence TK421, clinical bacteremia isolate containing hypervirulence plasmid carrying tra-associated conjugation machinery genes. Emergence conjugative plasmids could portend rapid dissemination among multidrug-resistant K. strains.
In an attempt to identify novel bacterial species, microbiologists have examined a wide range of environmental niches. We describe the serendipitous discovery gram-negative species from different type extreme niche: purchased vial antibiotic. The antibiotic hygromycin B was found be factory contaminated with which we designate Pseudomonas hygromyciniae sp. nov. proposed belongs P. fluorescens complex and is most closely related brenneri, proteolytica, fluorescens. strain SDM007T (SDM007T)...
ABSTRACT Hypermutator lineages of Pseudomonas aeruginosa arise frequently during the years airway infection experienced by patients with cystic fibrosis and bronchiectasis but are rare in absence chronic structural lung disease. Since onset COVID-19 pandemic, large numbers have remained mechanically ventilated for extended periods time. These prone to acquire bacterial pathogens that persist many weeks opportunity evolve within pulmonary environment. However, little is known about what types...
ABSTRACT Larvae of Galleria mellonella (the greater wax moth) are being increasingly used as a model to study microbial pathogenesis. In this model, bacterial virulence is typically measured by determining the 50% lethal dose (LD 50 ) strain or mutant. The use G. Pseudomonas aeruginosa pathogenesis, however, challenging because extreme sensitivity larvae bacterium. For some P. strains, few 1–5 colony-forming units sufficient kill mellonella, which poses challenges for LD values. reason,...
Mycobacterium xenopi is a slow growing non-tuberculous mycobacterium (NTM) isolated from water systems and has been associated with pseudo-outbreaks pulmonary infections in humans. We observed cluster of six respiratory cultures positive for M. within six-month period at our institution, approximately double normal isolation rate this organism. Only three the cases met clinical, radiographic, microbiologic criteria NTM infection. An investigation led by hospital's Healthcare Epidemiology...
ABSTRACT Gastrointestinal (GI) colonization by Klebsiella pneumoniae is a risk factor for subsequent infection as well transmission to other patients. Additionally, achieved many strain types that exhibit high diversity in genetic content. Thus, we aimed study strain-specific requirements K. GI applying transposon insertion sequencing three classical clinical strains: carbapenem-resistant strain, an extended-spectrum beta-lactamase producing and non-epidemic antibiotic-susceptible strain....
Abstract Background Klebsiella pneumoniae (K. pneumoniae) strains have been divided into two major categories: classical K. pneumonia , which are frequently multidrug-resistant and cause hospital-acquired infections in patients with impaired defenses, hypervirulent severe disseminated community-acquired immunologically normal hosts. Both types of may lead to bacteremia associated significant morbidity mortality. The relative burden these among bloodstream isolates within the United States is...