A5045154697- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Radiopharmaceutical Chemistry and Applications
- Cancer and Skin Lesions
- Medical Imaging Techniques and Applications
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Anesthesia and Pain Management
- Radiomics and Machine Learning in Medical Imaging
- Breast Implant and Reconstruction
- Medical Imaging and Pathology Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Antibiotic Resistance in Bacteria
- Pain Management and Opioid Use
- Cancer Treatment and Pharmacology
- Gastrointestinal disorders and treatments
- Nausea and vomiting management
- Monoclonal and Polyclonal Antibodies Research
- Antibiotic Use and Resistance
- Cancer Risks and Factors
- Peptidase Inhibition and Analysis
- Bacterial Identification and Susceptibility Testing
- Reconstructive Surgery and Microvascular Techniques
Post Graduate Institute of Medical Education and Research
2015-2024
Indraprastha Apollo Hospitals
2024
University of Waterloo
2024
Rensselaer Polytechnic Institute
2023
Government Medical College
1995-2022
Guru Gobind Singh Medical College and Hospital
2016-2021
Sultanah Aminah Hospital
2020
Austin Health
2020
Dayanand Medical College & Hospital
2019
Institute of Medical Sciences
1984-2018
PURPOSE: To assess patient and tumor characteristics associated with a complete pathologic response (pCR) in both the breast axillary lymph node specimens outcome of patients found to have pCR after neoadjuvant chemotherapy for locally advanced cancer (LABC). PATIENTS AND METHODS: Three hundred seventy-two LABC received treatment two prospective trials using four cycles doxorubicin-containing chemotherapy. Patients had total mastectomy dissection or segmental followed by more additional then...
HER2/neu is over expressed in 20–25% of breast cancers. HER2 cancers are aggressive and associated with poor prognosis. The aim this study was to develop the clinical grade Lu‐177‐trastuzumab its preliminary evaluation for specific tumor targeting positive cancer patients. Trastuzumab conjugated bifunctional chelator, DOTA, characterized integrity number molecules conjugated. Radiolabeling DOTA‐conjugated trastuzumab optimized using Lu‐177. Quality control parameters including radiochemical...
Although initial studies have shown the utility of fluorine-18 fluorodeoxyglucose (F-18 FDG) PET in detection and restaging recurrent breast carcinoma, scarce literature exists on F-18 FDG PET/computed tomography (CT). This retrospective study was carried out to evaluate role F-18-FDG PET/CT carcinoma its impact management.Retrospective analysis data 111 patients who underwent were suspected having out. imaging for distant metastases histologically proven locoregional recurrence 23 patients,...
Seroma is a frequent complication after breast cancer surgery. Closed suction drainage for several days the standard procedure to reduce seroma formation. The aim of this study was compare efficacy external compression dressing, suture flap fixation, and conventional method closed drains in prevention A total 161 patients were prospectively randomized three groups × two subgroups design into control (n = 48), dressing 53) suturing 49), subgroups, drain removal 75) early 75). All underwent...
Cardioplegia is an integral component of myocardial protection. Standard delivery cardioplegia includes antegrade and retrograde method. Retrograde technique may cause injury to the coronary sinus inadequate right ventricular protection while alone be especially through very stenotic vessels. Therefore, in this study we compare using compared combination vein on pump artery bypass graft surgery. This a cross sectional retrospective study. Two groups patients (antegrade combined with...
Non-surgical treatment has become the therapeutic method of choice in hemodynamically stable patients with liver trauma. There are a few reports endoscopic management traumatic hepatobiliary injuries such patients; however, optimal intervention is not known.Twenty from May 1997 to November 2005 were retrospectively evaluated.There 18 male and two female mean age 21.45 +/- 10.17 years (range 7-42 years). Seven children. Patients presented 19.4 17.04 days following Computed tomography (CT)...
K. Kumar S, N. Gupta, A. Rajwanshi, Joshi and G. Singh Immunochemistry for oestrogen receptor, progesterone receptor HER2 on cell blocks in primary breast carcinoma Objective: Steroid receptors human epidermal growth 2 (HER2) have been used predicting response to treatment cancers. Fine needle aspiration cytology can provide highly cellular material be such analysis. The present study was undertaken assess the reliability of (ER, PR) status as demonstrated by immunochemistry (IHC) from...
Rising incidents of aggression and violence against healthcare workers (HCWs) is widening the rift between patients their caregivers. So, aim study was to evaluate perceptions patient's attendants about factors responsible for widespread patient-physician distrust.An anonymous, questionnaire-based, cross-sectional conducted over a period one year in tertiary care teaching institute. Performas, adapted from WHO published questionnaire translated local language, were administered separately...
The erector spinae plane block is a newer technique of analgesia to the chest wall.The study was carried out establish efficacy and safety this in patients undergoing total mastectomy axillary clearance.Prospective randomized controlled study.Single tertiary care center, conducted over period 1 year.65 were included; final analysis done for 60 female clearance under general anesthesia randomly allocated two groups.Group B (block group) received ultrasound-guided at T5 level with ropivacaine...
Primary signet ring cell adenocarcinoma of the breast is a rare neoplasm. Similar to other mucinous neoplasms, it has low FDG avidity and poor prognosis compared with traditional ductal/lobular carcinomas. We present case 40-year-old woman skeletal fluorosis showing higher uptake Ga-prostate-specific membrane antigen in primary lesion metastatic sites F-FDG on PET/CT imaging. Additionally, diffuse increased prostate-specific was noticed entire skeleton, likely due fluorosis.
Breast cancer is a heterogenous disease at the molecular level thus, it can be hypothesized that different subtypes differ in their tumor microenvironment (TME) also. Understanding TME heterogeneity may provide new prognostic biomarkers and targets for therapy. For deciphering TME, immunohistochemistry immune markers (CD3, CD4, CD8, CD68, CD163, programmed death-ligand 1), Cancer-associated fibroblast [anti-fibroblast activating protein α (FAP-α), platelet-derived growth factor receptor...
To define the clinical and pathological predictors of locoregional recurrence (LRR) in locally advanced breast cancer (LABC) patients treated with neoadjuvant chemotherapy (NACT).We retrospectively reviewed outcome 141 stage II to III carcinoma at Department Radiotherapy, PGIMER, Chandigarh from 1998-2002. Mean age was 46 years, 49% were premenopausal 51% postmenopausal. The tumor T2 18%; T3 61% T4 26% patients. NACT regimen given FAC (5-fluorouracil, adriamycin cyclophosphamide) 85% CMF...
Triple negative breast cancer (TNBC) is a heterogeneous disease and an attempt was made to classify TNBCs into surrogate molecular subtypes using immunohistochemical markers. Tissue microarrays were constructed for 245 cases of TNBCs. For classification immunohistochemistry done on tissue cytokeratin 5/6, 4/14 (CK5/6, CK4/14), epidermal growth factor receptor (EGFR), vimentin, E-cadherin, claudin 3 7, androgen (AR) aldehyde dehydrogenase1A. The classified basal-like 1 (BL1) type (CK5/6 + ,...
Introduction The rising economic burden of cancer on healthcare system and patients in India has led to the increased demand for evidence order inform policy decisions such as drug price regulation, setting reimbursement package rates under publicly financed health insurance schemes prioritising available resources maximise value investments health. Economic evaluations are an integral component this important evidence. Lack existing costs health-related quality life (HRQOL) makes conducting...