A5078324189- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Protein Kinase Regulation and GTPase Signaling
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Sphingolipid Metabolism and Signaling
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Respiratory viral infections research
- Immune Response and Inflammation
- Viral Infections and Outbreaks Research
- Nitric Oxide and Endothelin Effects
- Biomedical Research and Pathophysiology
- Pharmacological Effects of Medicinal Plants
- Mitochondrial Function and Pathology
- SARS-CoV-2 detection and testing
- Immunotherapy and Immune Responses
- Lipid Membrane Structure and Behavior
- Cell death mechanisms and regulation
- Hepatitis B Virus Studies
- Malaria Research and Control
- Antimicrobial Resistance in Staphylococcus
- Endoplasmic Reticulum Stress and Disease
- Salmonella and Campylobacter epidemiology
Medical University of South Carolina
1994-2024
Bharat Biotech (India)
2007-2022
ICMR-National Institute of Virology
2020
Indian Council of Medical Research
2020
SummaryBackgroundBBV152 is a whole-virion inactivated SARS-CoV-2 vaccine (3 μg or 6 μg) formulated with toll-like receptor 7/8 agonist molecule (IMDG) adsorbed to alum (Algel). We previously reported findings from double-blind, multicentre, randomised, controlled phase 1 trial on the safety and immunogenicity of three different formulations BBV152 Algel-IMDG, Algel) one Algel-only control (no antigen), first dose administered day 0 second 14. The 3 Algel-IMDG were selected for this 2 study....
Background. Enteric fever caused by Salmonella Typhi remains a major public health problem in developing countries. Typbar-TCV is single-dose typhoid Vi polysaccharide–tetanus toxoid conjugate vaccine for persons ≥6 months of age.
Zika virus (ZIKV) is a mosquito-borne flavivirus that causes asymptomatic infection or presents only mild symptoms in majority of those infected. However, vaccination for ZIKV public health priority due to serious congenital and neuropathological abnormalities observed as sequelae the recent epidemics. We have developed an inactivated vaccine with African MR 766 strain. Here we show two doses provided 100% efficacy against mortality disease following challenge homotypic heterotypic FSS 13025...
We report the development and evaluation of safety immunogenicity a whole virion inactivated (WVI) SARS-CoV-2 vaccine (BBV152), adjuvanted with aluminum hydroxide gel (Algel), or TLR7/8 agonist chemisorbed Algel. used well-characterized strain an established Vero cell platform to produce large-scale GMP-grade highly purified antigen. Product manufacturing process were carried out in BSL-3 facility. Immunogenicity determined at two antigen concentrations (3μg 6μg), different adjuvants, mice,...
Abstract The COVID-19 pandemic is a global health crisis that poses great challenge to the public system of affected countries. Safe and effective vaccines are needed overcome this crisis. Here, we develop assess protective efficacy immunogenicity an inactivated SARS-CoV-2 vaccine in rhesus macaques. Twenty macaques were divided into four groups five animals each. One group was administered placebo, while three immunized with different candidates BBV152 at 0 14 days. All challenged fourteen...
The availability of a safe and effective vaccine would be the eventual measure to deal with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) threat. Here, we have assessed immunogenicity protective efficacy inactivated SARS-CoV-2 candidates BBV152A, BBV152B, BBV152C in Syrian hamsters. Three dose vaccination regimes induced significant titers SARS-CoV-2-specific IgG neutralizing antibodies. BBV152A BBV152B remarkably generated quick robust immune response. Post-SARS-CoV-2...
ABSTRACT Background We report the clinical efficacy against COVID-19 infection of BBV152, a whole-virion inactivated SARS-CoV-2 vaccine formulated with Toll-like receptor 7/8 agonist molecule adsorbed to alum (Algel-IMDG). Methods did double-blind, randomised, multicentre, phase 3 trial in 25 Indian hospitals evaluate efficacy, safety, and immunological lot consistency BBV152. Healthy adults (age 18–98 years) randomised 1:1 using computer-generated randomisation scheme received two...
Background. Japanese encephalitis (JE) is a vaccine-preventable acute disease. We report the results of phase 2/3 trial JENVAC, Vero cell–derived vaccine developed using an Indian strain JE virus (JEV).
Abstract This is a comprehensive report on immunogenicity of COVAXIN ® booster dose against ancestral and Variants Concern (VOCs) up to 12 months. It well known that neutralizing antibodies induced by COVID-19 vaccines wane within 6 months vaccination leading questions the effectiveness two-dose breakthrough infections. Therefore, we assessed persistence after two or three-dose with BBV152 safety in an ongoing phase 2, double-blind, randomized controlled trial (ClinicalTrials.gov:...
The world is currently facing an unprecedented global pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Predicting the next source of can be very challenging. As vaccination best way to prevent infectious disease, development effective vaccine against SARS-CoV-2 not only reduce morbidity and mortality associated with it, but also lessen economic impact. traditional method takes many years for a available society, should speeded up using approach fast-track...
Abstract The genetic diversity of Chikungunya virus (CHIKV) causing recurring outbreaks in India since 2006 was studied. epidemic caused by a strain the East, Central and South African (ECSA) genotype with 226A E1 glycoprotein. variant E1‐A226V mutation 2007 state Kerala where Aedes albopictus is abundant mosquito vector. Molecular epidemiology data scarce from other regions country. RT‐PCR, sequencing phylogenetic analyses CHIKV isolates 2009 to 2010 epidemics States Tamil Nadu Andhra...
Abstract Background BBV152 is a whole-virion inactivated SARS-CoV-2 vaccine (3 µg or 6 µg) formulated with Toll-like receptor 7/8 agonist molecule adsorbed to alum (Algel-IMDG). Earlier, we reported findings from phase 1 (vaccination regimen on days 0 and 14) randomised, double-blind trial the safety immunogenicity of three different formulations one control arm containing Algel (without antigen). Two were selected for 2 (days 28) study. Here, report interim controlled, BBV152: 3 Algel-IMDG....
A gene encoding phospholipase D (PLD) in Saccharomyces cerevisiae was identified. The 195 kDa product of PLD1 has 24% overall sequence identity with a plant PLD. Expression yeast PLD activity eliminated by one-step disruption. Yeast haploids lacking were deficient growth on non-fermentable carbon sources. Diploids expression unable to sporulate.
Phospholipase D (PLD) is activated in mammalian cells response to a variety of growth factors and may play role cell proliferation. Lysophosphatidic acid (LPA) bioactive metabolite potentially generated as result PLD activation. Two human prostate cancer lines, PC-3 LNCaP, express membrane activity. The effects LPA on activity proliferation were examined cells, which hPLD1a/1b. Phorbol 12-myristate 13-acetate (PMA) induced prolonged activation PLD, detected both intact membranes. transient...
ABSTRACT We report the development and evaluation of safety immunogenicity a whole virion inactivated SARS-COV-2 vaccine (BBV152), adjuvanted with aluminium hydroxide gel (Algel), or novel TLR7/8 agonist adsorbed Algel. used well-characterized SARS-CoV-2 strain an established vero cell platform to produce large-scale GMP grade highly purified antigen, BBV152. Product manufacturing were carried out in BSL-3 facility. Immunogenicity was determined at two antigen concentrations (3μg 6μg),...
Phospholipase D (PLD), which is present in bacterial, plant and animal cells, can serve as an important element of signal-transduction pathways. This study examined the potential role this enzyme regulation Saccharomyces cerevisiae. An assay vitro using a fluorescent 1-acyl-2-alkyl glycerophosphocholine substrate was used to assess PLD activity yeast cell extracts. A neutral membranes prepared from both haploid diploid evidenced by production phosphatidic acid phosphatidylbutanol presence...
Abstract Oral administration of BOS 2000 (1–10 mg/kg) elicited a dose related increase in the delayed hypersensitivity reaction (early 24 h and 48 h) mice. It also stimulated IgM IgG titre expressed form plaques (PFC) complement fixing antibody titre. The concentration cytokines (IL‐4, IFN‐ γ TNF‐ α ) serum with respect to T cell interactions, i.e. (CD4/CD8) proliferation lymphocytes were significantly increased at 10 mg/kg compared control. results these studies demonstrated...
Typhoid fever due to Salmonella Typhi and invasive nontyphoidal (iNTS) infections caused by serovars Enteritidis (SE) Typhimurium (STm) are major pediatric health problems in sub-Saharan Africa. has high complication rates, iNTS have case fatality rates; moreover, emerging antimicrobial resistance is diminishing treatment options. Vi capsule-based typhoid conjugate vaccine (Typbar-TCV™), licensed India pre-qualified the World Health Organization, elicits durable immunity when administered...
Abstract The COVID-19 pandemic is a global health crisis that has severely affected mankind and posed great challenge to the public system of countries. availability safe effective vaccine need hour overcome this crisis. Here, we have developed assessed protective efficacy immunogenicity an inactivated SARS-CoV-2 (BBV152) in rhesus macaques (Macaca mulata). Twenty were divided into four groups five animals each. One group was administered placebo while three immunized with different...