A5002830173- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Plant Genetic and Mutation Studies
- Vaccine Coverage and Hesitancy
- GABA and Rice Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Image Processing Techniques and Applications
- Plant Molecular Biology Research
- Genetic Mapping and Diversity in Plants and Animals
- Advancements in Transdermal Drug Delivery
- COVID-19 epidemiological studies
- vaccines and immunoinformatics approaches
- Viral Infections and Outbreaks Research
- Long-Term Effects of COVID-19
Bhabha Atomic Research Centre
2024
ICMR-National Institute of Virology
2020-2023
Abstract The COVID-19 pandemic is a global health crisis that poses great challenge to the public system of affected countries. Safe and effective vaccines are needed overcome this crisis. Here, we develop assess protective efficacy immunogenicity an inactivated SARS-CoV-2 vaccine in rhesus macaques. Twenty macaques were divided into four groups five animals each. One group was administered placebo, while three immunized with different candidates BBV152 at 0 14 days. All challenged fourteen...
We have isolated the new severe acute respiratory syndrome coronavirus-2 variant of concern 202 012/01 from positive coronavirus disease 2019 cases that travelled UK to India in month December 2020. This emphasizes need for strengthened surveillance system limit local transmission this variant.
The apprehension of needles related to injection site pain, risk transmitting bloodborne pathogens, and effective mass immunization have led the development a needle-free system (NFIS). Here, we evaluated efficacy NFIS needle (NIS) for delivery immunogenicity DNA vaccine candidate ZyCoV-D in rhesus macaques against SARS-CoV-2 infection. Briefly, 20 were divided into 5 groups (4 animals each), that is, I (1 mg dose by NIS), II (2 III NFIS), IV NFIS) V (phosphate-buffer saline [PBS])....
Sir, Coronaviruses belong to the family Coronaviridae with a single-stranded, positive-sense RNA genome (26-32 kb), and are known cause infections in humans animals. Cases of pneumonia unknown aetiology were reported Wuhan, China, early December 2019, identified be caused by novel coronavirus, named as severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)1. As May 27, 2020, more than 5.7 million cases worldwide above 3,52,000 deaths2. efforts being made for development vaccines...
The emergence of SARS-CoV-2 variants in places where the virus is uncontained poses a global threat from perspective public health and vaccine efficacy. Travel has been important factor for easy spread worldwide. India also observed importation through international travelers.In this study, we have collected oropharyngeal nasopharyngeal swab specimens 58 individuals with travel history United Arab Emirates (UAE), East, West South Africa, Qatar, Ukraine Saudi Arabia arrived during...
Abstract The COVID-19 pandemic is a global health crisis that has severely affected mankind and posed great challenge to the public system of countries. availability safe effective vaccine need hour overcome this crisis. Here, we have developed assessed protective efficacy immunogenicity an inactivated SARS-CoV-2 (BBV152) in rhesus macaques (Macaca mulata). Twenty were divided into four groups five animals each. One group was administered placebo while three immunized with different...
Abstract Vaccines remain the key protective measure to achieve herd immunity control disease burden and stop COVID-19 pandemic. We have developed assessed immunogenicity efficacy of two formulations (1mg 2mg) ZyCoV-D (a plasmid DNA based vaccine candidates) administered through Needle Free Injection System (NFIS) syringe-needle (intradermal) in rhesus macaques with three dose regimens. The candidate 2mg using elicited a significant immune response development SARS-CoV-2 S1 spike region...
The genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), belonging to the family Coronaviridae, encodes for structural, non-structural, and accessory proteins, which are required replication virus. These proteins encoded by different genes present on SARS-CoV-2 genome. expression pattern these in host cells needs be assessed. This study was undertaken understand transcription Vero CCL-81 during course infection.Vero were infected with virus inoculum having a 0.1...
International travel has been the major source for rapid spread of new SARS-CoV-2 variants across globe. During genomic surveillance, a total 212 positive clinical specimens were sequenced using next-generation sequencing. A complete genome could be retrieved from 90 specimens. Of them, 14 sequences belonged to Eta variant international travelers (n = 12) and local residents 2) India, 76 other variants. all Eta-positive specimens, virus isolates obtained six travelers. Many interest have...
Abstract Background Considering the potential threat from emerging SARS-CoV-2 variants and rising COVID-19 cases, genomic surveillance is ongoing in India. We report herewith isolation of P.2 variant (B.1.1.28.2) international travelers further its pathogenicity evaluation comparison with D614G (B.1) hamster model. Methods Virus was performed Vero CCL81 cells characterization by next generation sequencing. The isolate assessed Syrian model compared B.1 variant. Results B.1.1.28.2 isolated...
Abstract A photoperiod-insensitive mutant was isolated from a gamma rays-induced M 2 population of Joha rice landrace, Kon . The found to be unique, and the induced photoperiod insensitivity conditioned by single recessive gene. Towards gene tagging, 402 SSR InDel markers were screened, later polymorphic used in bulk segregant analysis (BSA) F 'mutant x Kalijeera (distant parent)'. BSA identified an association marker RM527 with this trait. This is present chromosome 6 genome. Including...
Abstract Background Assam's aromatic Joha rice is a unique class famous for its aroma, taste, and nutritional benefits, which fetch high market prices in domestic international markets. landraces are inherently poor yielders due to their strong aroma predominantly photoperiod sensitivity. Hybridization involving non-aromatic HYVs improves yield with concomitant loss of quality. In this context, mutation breeding, sustainable approach where genetic mutations induced create desirable traits,...
Abstract Multiple SARS-CoV-2 variants have been emerged and created serious public health in the affected countries. The variant of Concern associated with high transmissibility, disease severity escape mutations is threat to vaccination program across globe. Travel has important factor spread worldwide. India also witnessed dreadful effect these variants. Here, we report Isolation characterization VOC, 20H/501Y.V2 (B.1.351), from UAE travelers India. virus isolate would be useful determine...
Abstract The study investigates the replication cycle and transcriptional pattern of B.1.1.7 variant. It was observed that variant required a longer maturation time. response demonstrated higher expression ORF6 ORF8 compared to nucleocapsid transcript till eclipse period which might influence viral replication. number infectious viruses titer is in B.1.1.7, despite lesser copy than B.1, indicating infectivity.