A5012813031- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Nutrition and Physiology
- Vaccine Coverage and Hesitancy
- Livestock and Poultry Management
- Probiotics and Fermented Foods
- GABA and Rice Research
- Diet and metabolism studies
- Gut microbiota and health
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Seed and Plant Biochemistry
- Food composition and properties
- Biosensors and Analytical Detection
- Cancer Immunotherapy and Biomarkers
- Cholesterol and Lipid Metabolism
- COVID-19 Impact on Reproduction
- Essential Oils and Antimicrobial Activity
- Molecular Communication and Nanonetworks
- Food and Agricultural Sciences
- Diet, Metabolism, and Disease
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
Emory University
2022-2025
National Institute of Immunology
2017-2023
Children's Healthcare of Atlanta
2022-2023
Institute of Genomics and Integrative Biology
2023
Lund University
2022
Sinai Health System
2022
Central Avian Research Institute
2018-2021
Indian Council of Medical Research
2021
University of Washington
2021
Rajiv Gandhi Technical University
2016
The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition B cell pool unperturbed hematopoiesis. Lineage tracing stratified murine based on timing output, revealing a substantial portion originated within restricted neonatal window. In addition B-1a cells, early-life time-stamped included clonally interrelated IgA plasma in gut bone marrow. These were actively maintained by memory...
NDV-HXP-S is a recombinant Newcastle disease virus–based vaccine against SARS-CoV-2, which expresses an optimized (HexaPro) spike protein on its surface. The can be produced in embryonated chicken eggs using the same process as that used for production of vast majority influenza virus vaccines. Here, we performed secondary analysis antibody responses after vaccination with inactivated phase 1 clinical study Thailand. SARS-CoV-2 neutralizing and binding activity postvaccination serum samples...
Background: Vaccines against COVID-19 target the spike protein. There is minimal information on longitudinal immune profiling in recovered versus naïve and vaccinated non-vaccinated healthcare workers (HCWs). Methods: This a prospective observational cohort of pediatric HCWs (pHCWs) conducted during 2020-2022 at an academic center, exploring impact vaccination immunoglobulin G (IgG) antibody titers over time cross-reactivity with other coronaviruses, including SARS-CoV-1, MERS-CoV, seasonal...
Emerging variants, especially the recent Omicron variant, and gaps in vaccine coverage threaten mRNA mediated protection against SARS-CoV-2. While children have been relatively spared by ongoing pandemic, increasing case numbers hospitalizations are now evident among children. Thus, it is essential to better understand magnitude breadth of vaccine-induced immunity circulating viral variant concerns (VOCs). Here, we compared humoral immune responses adolescents adults 1 month after two-dose...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a pandemic. As immunity to endemic human coronaviruses (i.e. NL63 or OC43) wanes leading re-infection, it was unknown if SARS-CoV-2 would also decline permitting repeat infections. Recent case reports confirm previously infected individuals can become re-infected; however, re-infection may be due heterogeneity in the initial infection host immune response, result of with variant strain that escapes pre-existing immunity....
Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health.They can serve as alternatives to the synthetic selective estrogen receptor modulators which currently being used in hormone replacement therapy.Estrogens play many important physiological roles men women.In women, life is severely affected by variety estrogen-related conditions such osteoporosis, cognitive cardiovascular...
Summary B‐cell memory was long characterized as isotype‐switched, somatically mutated and germinal centre ( GC )‐derived. However, it is now clear that the pool a complex mixture includes unswitched unmutated cells. Further, expression of CD 73, 80 273 has allowed categorization into multiple subsets, with combinatorial markers increasing progression, isotype‐switching acquisition somatic mutations. We have extended these findings to determine whether can be used identify IgM phenotypically...
It is widely known that athletes used to rely on training and good nutrition provide maximum results.But now maintain a competitive edge, are switching nutraceuticals.They dietary supplements health benefits.Nutraceuticals commonly enhance improve the performance of athletes.This has triggered sale nutraceuticals in market stores gyms selling hundreds different supplements.These nutritional usually claim strength, stamina, help build lean muscle, burn excess fat.There many available for...
Classically, IgA in the gut prevents invasion of microorganisms to systemic organs through process neutralization and immune exclusion. Interestingly, recent reports suggest that might help biofilm formation promote bacterial growth inside intestine.In this study, we used flow cytometry, ELISA, chemical models colitis test whether quality quantity can select for persistence gut.We found members Proteobacteria, such as γ-Proteobacteria SFB, are preferentially coated by WT mice. In partial...
This study investigated growth performance, efficiency, lipid composition, metabolism, health indices, and serum chemistry of broiler chicken fed flaxseed meal (FSM) Cr. Five dietary treatments were formulated – T1 (control), T2 (100 g FSM), T3 FSM + 0.5 ppm Cr), T4 1.0 T5 1.5 Cr). Each treatment was assigned six replicate groups day-old chicks with eight birds in each. Feeding 100 exerted negative effects on the performance during starter phase only (0-3 weeks) overall efficiency parameters...