A5084986434- Hemoglobinopathies and Related Disorders
- SARS-CoV-2 and COVID-19 Research
- Iron Metabolism and Disorders
- Hemoglobin structure and function
- Blood groups and transfusion
- Pharmacological Effects and Toxicity Studies
- Folate and B Vitamins Research
- Epilepsy research and treatment
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Virus-based gene therapy research
- Ethics and Legal Issues in Pediatric Healthcare
- Innovations in Medical Education
- Cardiovascular Function and Risk Factors
- Health Sciences Research and Education
- Metabolism and Genetic Disorders
- Bacterial Identification and Susceptibility Testing
- Veterinary Pharmacology and Anesthesia
- Inflammatory mediators and NSAID effects
- Gastrointestinal disorders and treatments
- Health Literacy and Information Accessibility
- Hepatitis B Virus Studies
- Health and Medical Research Impacts
- Heme Oxygenase-1 and Carbon Monoxide
- Vaccine Coverage and Hesitancy
Emory University
2023-2025
American University of Beirut
2025
Children's Healthcare of Atlanta
2024
Services Australia
2024
University of Bristol
2012
Multidrug resistant (MDR) Gram-negative bacterial infections are considered a major public health threat. The objectives of this study were to describe the epidemiology, potential contributing factors, and antimicrobial resistance patterns associated with caused by MDR bacteria (GNB) in non-immunocompromised children adolescents. This was retrospective observational conducted at American University Beirut Medical Center (AUBMC) from 2009 2017. included patients 18 years age or younger GNB...
This observational prospective cross-sectional study was conducted during the last 4 months of COVID-19 pandemic to determine whether parental hesitancy vaccinate their children against had improved compared earlier studies in other countries showing high levels hesitancy. Methods: Parents were surveyed from January until May 16, 2023, at two tertiary medical centers Beirut, American University Beirut Medical Center (AUBMC) and Saint George Hospital (SGHUMC). Results: The enrolled 950...
Background/Objective: Cobalamin (B12) deficiency is reported in 18% of adults with sickle cell disease (SCD) and only 10% without SCD; limited data are available on children. Diagnosing B12 challenging given the lack an established gold standard method assessment unique renal features SCD. metabolism can be impacted by clinical use nitrous oxide gas (N2O), which a therapy for SCD pain some European countries. In response to emerging reports neurologic sequalae patients receiving N2O, we...
Background: Vaccines against COVID-19 target the spike protein. There is minimal information on longitudinal immune profiling in recovered versus naïve and vaccinated non-vaccinated healthcare workers (HCWs). Methods: This a prospective observational cohort of pediatric HCWs (pHCWs) conducted during 2020-2022 at an academic center, exploring impact vaccination immunoglobulin G (IgG) antibody titers over time cross-reactivity with other coronaviruses, including SARS-CoV-1, MERS-CoV, seasonal...
ABSTRACT We present a prospective randomized, placebo‐controlled trial of intravenous arginine in patients 3–21 years hospitalized with sickle cell disease vaso‐occlusive pain episodes (SCD‐VOE) at two tertiary‐care children's hospitals. Participants were randomized into 1 3 arms: Standard‐dose (SD; 100 mg/kg/dose) every 8 h, Loading‐dose (200 mg/kg followed by SD), or Placebo . The primary outcome was total parenteral opioid use (TPO). Secondary outcomes included time‐to‐crisis‐resolution,...
The pathogenicity of Haemoplasma spp. in cats varies with 'Candidatus Mycoplasma haemominutum' (CMhm) causing subclinical infection while haemofelis (Mhf) often induces haemolytic anaemia. aims this study were to characterise the acute phase response (APR) cat experimental Mhf or CMhm, and determine whether chronic feline immunodeficiency virus (FIV) influences response. proteins serum amyloid A (SAA), haptoglobin (Hp) α-1-acid glycoprotein (AGP) concentrations measured pre-infection every...
Objectives Acute kidney injury (AKI) is a well‐known but poorly documented adverse effect of non‐steroidal anti‐inflammatory drugs (NSAIDs) in cats. We aimed to describe instances NSAID‐associated AKI cats and survey Australian veterinarians on NSAID use acute settings. Methods Medical records that developed an subsequent the administration meloxicam were obtained by searching databases seven practices Queensland, as well contemporaneously contacting select veterinary colleagues authors both...
ObjectivesDetermine SARS-CoV-2 IgG antibody incidence over time in unvaccinated pediatric healthcare workers (pHCWs).DesignProspective longitudinal cohort of pHCWs measuring new infection after initial prevalence was established at 4.1% with seropositive predominance emergency department (ED)-based pHCWs. Serum samples were collected follow-up visits to detect seropositivity. Univariate analysis performed estimate different rates between participant demographics, job, employment location and...
Abstract Presentation Date: 6/9/2024 Start Time: 1:51:00 PM Background Cobalamin (B12)-deficiency has been reported in 18% of adults with sickle cell disease (SCD) vs 10% without SCD. The prevalence B12-deficiency children SCD is controversial limited and contradictory data the literature. A higher frequency suspected due to rates hemolysis, erythrocyte turnover, increased nutritional requirements. B12 an important cofactor for integral metabolic pathways involved DNA synthesis, production...
A 12‐year‐old female spayed Domestic Shorthair cat presented with a 4‐day history of lethargy, inappetence and vomiting. Physical findings included grade 2/6 heart murmur cranial abdominal pain on palpation. Serum biochemistry revealed elevated total bilirubin liver enzymes activities. Abdominal ultrasound multiple pancreatoliths, cholelithiasis dilation the pancreatic duct. During exploratory laparotomy, catheterisation duct retrograde orthograde flushing to remove pancreatoliths was...