As the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic expands, genomic epidemiology and whole genome sequencing are being used to investigate its transmission evolution. Against backdrop of emergence "variants concern" (VOCs) during December 2020 an upsurge in a state western part India since January 2021, analysis spike protein mutations using sequence structural approaches were undertaken identify possible new variants gauge fitness current circulating...

Segmentation, a new method, for color, gray‐scale MR medical images, and aerial is proposed. The method based on morphology. Edge detection algorithm includes function edge marker‐controlled watershed segmentation. It features the simple implemented in MATLAB. segmentation has been proved to be powerful fast technique both contour region‐based In principle, depends ridges perform proper segmentation, property that often fulfilled where boundaries of objects are expressed as ridges. For it...

The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcription to regulate cell survival and proliferation. Dynamic control of degradation in response stress signals are critical for suppression. N terminus (NT) contains two transactivation domains (TAD1 TAD2), proline-rich region (PRR), multiple phosphorylation sites. Previous work revealed the NT reduced vitro. Here, we show TAD2 PRR inhibit by directly interacting with domain (DBD). NMR spectroscopy...

The article explains how to query a database of flower patent images using both an example image and color names. This consists that have been digitized from photographs submitted as part applications for patents the US Patents Trademark Office. must be queried by name, so those checking new buying cultivation can use it.

Resistance of Leishmania parasites to miltefosine, which is only available oral drug, a great concern. We have analyzed global gene expression profiles miltefosine-unresponsive and miltefosine-responsive donovani in order understand the various metabolic processes involved miltefosine drug resistance. The microarray data clearly indicated role oxidative metabolism Furthermore, fluorescence microscopy experiments suggested that L. resists accumulation reactive oxygen species subsequent...

Non-contact human body vital parameter measurements are getting more attention and have been extensively studied in a short span of time. One such techniques is the heart rate (HR) estimation based on video recording face known as remote photoplethysmogram (rPPG). Usually, recorded gets contaminated due to illumination variation ambient light, motion artifacts, other environmental factors. Thus, extracting reliable rPPG signal challenging task. In this paper, novel spatial-temporal filtering...

We describe a new multi-phase, color-based image retrieval system, FOCUS (Fast Object Color-based qUery System), with an online user interface which is capable of identifying multi-colored query objects in the presence significant, interfering backgrounds. The object may occur arbitrary sizes, orientations and locations database images. color features used to have been developed based on need for speed matching ease computation complex images while maintaining scale rotation invariance...

Densities and viscosities of the binary mixtures acetronitrile with tetrahydrofuran, 1,3-dioxolane, 1,4-dioxane were measured over entire range composition at (298.15, 308.15, 318.15) K. Ultrasonic speeds these have also been 298.15 From experimental data, values excess molar volumes (V E), viscosity deviations (Δη), in isentropic compressibility (ΔKs) calculated. These results fitted to Redlich−Kister polynomial equation. The density data analyzed by some semiempirical models, discussed...

Hypericin, a natural compound from Hypericum perforatum (St. John's wort), has been identified as specific inhibitor of Leishmania donovani spermidine synthase (LdSS) using integrated computational and biochemical approaches. Hypericin showed in vitro inhibition recombinant LdSS enzyme activity. The vivo estimation levels promastigotes after hypericin treatment significant decreases the pools parasites, indicating target specificity molecule. inhibitor, hypericin, antileishmanial activity,...

Densities, viscosities and sound speeds of eight binary mixtures 2-ethoxyethanol with methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, 1-heptanol 1-octanol are determined over the entire range mole fractions at 298.15 K. The excess molar volume (V E), viscosity deviations (Δη) Gibbs free energy activation for viscous flow (ΔG∗E) have been investigated from these experimental density (ρ) (η) values. data correlated by Grunberg Nissan, Tamura–Kurata Hind correlation equation....

Remote photoplethysmography (rPPG) is a non-contact camera based method that seems to be the most promising technology for remote cardiac health assessment. The conventional rPPG methods have played significant role in growth of low-cost monitoring system. However, they are on certain assumptions, and their performance may degrade with real-time dynamic interferences. Recently, deep neural network (DNN) been introduced domain proves perform well noisy environment. In this work, we proposed...

Abstract Repurposing drugs and adjuvants is an attractive choice of present therapy that reduces the substantial costs, chances failure, systemic toxicity. Mycobacterium indicus pranii was originally developed as a leprosy vaccine but later has been found effective against Leishmania donovani infection. To extend our earlier study, here we reported immunotherapeutic modulation splenic circulatory neutrophils in favour hosts actually serve pro‐parasitic portable shelter to infection...

Ornithine decarboxylase ( Ld ODC ), a key enzyme in polyamine biosynthesis Leishmania donovani, catalyzes the conversion of ornithine to putrescine that is finally used for synthesis spermidine and other polyamines. Inhibition likely deplete parasite trypanothione may result increased reactive oxygen species ROS ). Sequence as well structure human shows significant difference; therefore, we have identified novel specific inhibitors . These are able inhibit recombinant decrease intracellular...

Abstract The p53 tumor suppressor is frequently inactivated by mutations in cancer. Most are located the DNA-binding domain, causing local disruption of surface or global misfolding. Rescuing structural defect mutant an attractive therapeutic strategy, but its potential remains unproven due to a lack drugs capable efficiently rescuing misfolded p53. Although tumors inactive at 37°C, approximately 15% temperature sensitive (ts) and regain activity 32°C 34°C (ts mutants). This achievable using...

Pulse transit time (PTT) has been widely used for cuffless blood pressure (BP) measurement. But, it requires more than one cardiovascular signals involving sensing device. In this paper, we propose a method continuous measurement with the help of left ventricular ejection (LVET). A MEMS-based accelerometric sensor acquires seismocardiogram (SCG) signal at chest surface, and then, LVET information is extracted. Both systolic diastolic pressures are estimated by calibrating system original...

Video summarization is a key component in providing Internet users way to quickly browse video clip different levels of detail, without the need view entire clip. We present hybrid approach summary generation, which automatically process video, creating multimedia summary, while easy-to-use interfaces for verification, correction, and augmentation generated story segments extracted content. Algorithms are developed solve sub-problems segmentation, boundary refinement, generation. The use...

A new metal-organic hybrid complex [Cu(5,5′-dmbipy) (D-cam) (H2O)]n (1), (5,5′-dmbipy = 5,5′-dimethyl-2,2′-bipyridine, D-cam D-camphoric acid anion) was hydrothermally synthesized. This characterized by FTIR spectroscopy, TGA, and single-crystal X-ray diffraction. Crystallographic studies show that the title 1 crystallizes in an orthorhombic system with a P212121 space group 06.9518(05) Ǻ, b 13.5516(13) c 22.6380(02)Ǻ; V 2132.7(3) Ǻ3. The CuII adopts square pyramidal configuration. DFT study...

We describe a solution to the problem of indexing images flowers for searching flower patents database by color. use natural language color classification derived from ISCC-NBS system and X Window names effectively domain knowledge available, provide perceptually correct retrieval allow queries. have developed an automatic iterative segmentation algorithm with knowledge-driven feedback isolate region background. The is defined present in their relative proportions. can be queried example...

Abstract Apparent molar volumes, viscosity B-coefficients, and apparent isentropic compressibilities of glycine, L-alanine, L-valine L-leucine in 0.062, 0.125 0.256 mol kg−1 aqueous tetra-butyl ammonium bromide (TBAB) solution have been determined at 298.15 K from their experimental density, flow time sound speed measurements, respectively. The standard partial volumes are used to calculate the corresponding volume transfer infinite dilution, water TBAB solutions. linear correlation for a...