A5105023748- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Urticaria and Related Conditions
- Eosinophilic Disorders and Syndromes
- RNA modifications and cancer
- Sympathectomy and Hyperhidrosis Treatments
- Macrophage Migration Inhibitory Factor
- Cytomegalovirus and herpesvirus research
- Synthesis and Biological Evaluation
- Systemic Lupus Erythematosus Research
- Oral Health Pathology and Treatment
- Skin Diseases and Diabetes
- Rheumatoid Arthritis Research and Therapies
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders
- Reproductive System and Pregnancy
- IgG4-Related and Inflammatory Diseases
- Monoclonal and Polyclonal Antibodies Research
Armed Forces Medical College
2024-2025
Banaras Hindu University
1996-2021
Institute of Medical Sciences
2012-2021
Darshan Dental College and Hospital
2014
Instituut voor Tropische Geneeskunde
2013
Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector-borne parasitic disease. A recent epidemic in Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per year. Resistance against antimonial drugs has probably been a contributing factor persistence this epidemic. Here we use whole genome sequences from 204 clinical isolates track evolution epidemiology L. ISC. We identify independent radiations that have emerged since bottleneck...
Promastigote miltefosine (MIL) susceptibility was performed on Leishmania donovani isolates from Indian patients with visceral leishmaniasis treated MIL. Isolates that were obtained before the onset of MIL treatment, after completion treatment (29th day), or at time failure, screened using in vitro promastigote assay. The pre-treatment (N = 24, mean IC50 ± SEM 3.74 0.38 μM) significantly higher than post-treatment group 26, 6.15 0.52 μM; P 0.0006) but similar cured 22, 5.58 0.56 and those...
Members of the Bcl-2 family are major regulators apoptosis in mammalian cells and hence infection-induced perturbations their expression could result into elimination parasites or creation a niche favoring survival. In this investigation, we uncover novel role host sustaining Leishmania donovani infection. A rapid two-fold increase occurred response to parasite challenge. Downregulation post infection using siRNA functional inhibition small molecule inhibitors interfered with intracellular...
Abstract The protozoan Leishmania braziliensis causes cutaneous leishmaniasis (CL) in endemic regions. In murine models, neutrophils (PMNs) are recruited to the site of infection soon after parasite inoculation. However, roles during chronic and human disease remain undefined. We hypothesized that help maintain a systemic inflammatory state subjects with CL. Lesion biopsies from all patients CL tested contained expressing HLA-DR, molecule thought be restricted professional antigen-presenting...
Visceral leishmaniasis (VL) is a potentially fatal parasitic disease associated with fever, cachexia and impaired protective T-cell responses against the parasite. Peripheral blood leukocytes from 105 subjects VL healthy control endemic region of Muzaffarpur, Bihar, India, were compared using flow cytometry reverse-transcriptase quantitative polymerase chain reaction. Findings correlated clinical data. An expanded population low-density neutrophils that expressed HLA-DR, CD80 CD86 was...
Nitric oxide (NO) is an anti-microbial effector of the innate immune system which plays major role in non-specific killing various pathogens including protozoan parasites. However, due to subversion host’s processes by pathogens, suboptimal production NO frequently found many infection models. Previous studies have shown suppressed during Leishmania donovani infection, causative agent visceral leishmaniasis (VL). Availability L-Arginine, a semi-essential amino acid required for inducible...
Visceral leishmaniasis (VL) is a chronic parasitic disease associated with suppressed T cell responses. Although parasites reside intracellularly in macrophages during VL, neutrophils are the first host to infiltrate infection site and phagocytose parasite. Subsets of unusual characteristics have been documented human but whether total neutrophil population aberrant not known. Therefore, we examined phenotypic unfractionated polymorphonuclear leukocyte (neutrophils) from subjects active...
'Crohn's disease' is an inflammatory granulomatous disease of the gastrointestinal tract with extra-intestinal manifestations. Oral lesions may precede intestinal and serve as a source for histological diagnosis. We present case orofacial Crohn's where symptoms were about 13 years occasional constipation was present, since 6 months. examination plays important role in early diagnosis disease.
ABSTRACT We compared the two formats of rKE16 antigen-based rapid tests, a flowthrough test (KEFT) and lateral flow (KELF), with rK39 for diagnosis visceral leishmaniasis. Sensitivities KEFT (99%, 198/200) (99.5%, 199/200) were comparable higher than that KELF (95.5%, 191/200). In control groups comprising subjects diseases from areas nonendemicity or endemicity different diseases, specificities all three except specificity was in controls endemicity.