A5077200492- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Pancreatic and Hepatic Oncology Research
- Glaucoma and retinal disorders
- CAR-T cell therapy research
- Parasites and Host Interactions
- Immunotherapy and Immune Responses
- Neuroendocrine Tumor Research Advances
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Biliary and Gastrointestinal Fistulas
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Inflammatory mediators and NSAID effects
- Cancer Cells and Metastasis
- SARS-CoV-2 and COVID-19 Research
- Corneal surgery and disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Colorectal Cancer Screening and Detection
- Thyroid Cancer Diagnosis and Treatment
- NF-κB Signaling Pathways
Guru Nanak Dev University
2013-2025
University of Colorado Denver
2013-2025
University of Colorado Anschutz Medical Campus
2016-2025
University of Colorado Hospital
2022
John Wiley & Sons (United States)
2020
Hudson Institute
2020
Rush University Medical Center
2017
Columbia College - Missouri
2017
Institute of Medical Sciences
2010-2013
Banaras Hindu University
2010-2013
Abstract Introduction A subpopulation (CD44 + /CD24 - ) of breast cancer cells has been reported to have stem/progenitor cell properties. The aim this study was investigate whether the unique ability invade, home, and proliferate at sites metastasis. Methods CD44 CD24 expression determined by flow cytometry. Northern blotting used determine proinvasive 'bone lung metastasis signature' genes. matrigel invasion assay intracardiac inoculation into nude mice were evaluate invasion, homing...
Abstract Five-year survival for human papilloma virus-unrelated head and neck squamous cell carcinomas remain below 50%. We assessed the safety of administering combination hypofractionated stereotactic body radiation therapy with single-dose durvalumab (anti-PD-L1) neoadjuvantly ( n = 21) NCT03635164 ). The primary endpoint study was safety, which met. Secondary endpoints included radiographic, pathologic objective response; locoregional control; progression-free survival; overall survival....
Parthenolide, a sesquiterpene lactone, shows antitumor activity in vitro, which correlates with its ability to inhibit the DNA binding of antiapoptotic transcription factor nuclear kappaB (NF-kappaB) and activation c-Jun NH(2)-terminal kinase. In this study, we investigated chemosensitizing parthenolide vitro as well MDA-MB-231 cell-derived xenograft metastasis model breast cancer. HBL-100 cells were used measure vitro. Parthenolide was effective either alone or combination docetaxel...
PCR based diagnosis for Visceral Leishmaniasis (VL), despite numerous published primers, remains far from being applied in the field. The present study was planned to design a Leishmania specific diagnostic assay and evaluate its sensitivity specificity on sample size, which best of our knowledge is largest ever screened one study.Leishmania primers were developed using 18S rRNA gene their evaluated 500 parasitologically confirmed patients with VL 25 Post Kala-azar Dermal (PKDL) patients....
Salivary gland malignancies are rare, accounting for less than 5% of head and neck cancers. Mucoepidermoid carcinoma (MEC) is the most common salivary tumour, predominantly found in parotid gland. However, it has rarely been reported tongue. Histologically, these tumours typically exhibit a combination mucous, squamous intermediate cell components. In 2022 version WHO classification tumours, MAML2 rearrangement desirable but not essential diagnosis. rare cases, MEC may lack component, posing...
Endoscopic flexor hallucis longus (FHL) tendon transfer can be used in the management of acute or chronic Achilles rupture (ATR), including elite sportspeople. A recent cadaveric study demonstrated that an increased ultimate load could applied using FHL with interference screw and cortical button a tension slide technique compared alone. The aim this was to explore patient-reported functional outcomes following modification operation. We reviewed imaging, history, patient-related outcome...
Breast cancer metastasis predominantly occurs via lymphatic vessels. However, the study of vessels and lymphangiogenesis has been hampered by lack specific markers. Recently, antibodies directed against M2A (D2-40), Podoplanin, Prox-1 that specifically mark in paraffin-embedded sections have become available. These were used to archival paraffin normal breast (n = 23), fibrocystic disease 7), ductal carcinoma situ 32), invasive 50), lobular 5). In addition, endothelial proliferation was...
Abstract The anti‐tumour actions of cyclooxygenases (COX) are thought to be mediated by inhibition prostaglandin E 2 (PGE ) synthesis. However, COX‐2 also alters cellular production other prostaglandins such as prostacyclin (PGI ). latter action is believed important for the development adverse cardio‐vascular events. Microsomal PGES (mPGES‐1) an enzyme downstream and affects PGE only. It possible that targeting mPGES‐1 could decrease without affecting PGI production. In order assess...
ABSTRACT Serial dilution of blood and spleen biopsy specimens, plated on Novy-MacNeal-Nicolle (NNN) agar using microtiter culture plates, is a sensitive reproducible method for detection growth Leishmania parasites. Plates could be easily monitored, rapidly detected. Moreover, parasite number may estimated this technique.
Members of the Bcl-2 family are major regulators apoptosis in mammalian cells and hence infection-induced perturbations their expression could result into elimination parasites or creation a niche favoring survival. In this investigation, we uncover novel role host sustaining Leishmania donovani infection. A rapid two-fold increase occurred response to parasite challenge. Downregulation post infection using siRNA functional inhibition small molecule inhibitors interfered with intracellular...
Previously developed methods for noninvasive PCR diagnosis of visceral leishmaniasis (VL) have significant limitations. Diagnosis VL using and buccal swabs was evaluated in 307 subjects, including 148 patients confirmed to VL. This method is simple well tolerated has good potential development, showing 83% sensitivity with 90.56% specificity control groups.
Macrophage inhibitory cytokine 1 (MIC-1), a divergent member of the transforming growth factor beta superfamily, plays role in progression number cancers, including breast, gastric, prostate and colorectal carcinomas. Serum MIC-1 levels are elevated patients with metastatic prostate, breast In vitro studies have revealed cell type-specific for senescence apoptosis. activates survival kinase AKT/PKB neuronal cells. Depending on type, it or represses MAP kinases ERK1/2. Mechanisms responsible...
Regional variations in susceptibility of Leishmania donovani clinical isolates have been reported to antimonials but not other antileishmanial drugs. Therefore, we evaluated the four drugs use 28 from endemic and non-endemic regions J774A.1 macrophage cell line, found increased tolerance miltefosine paromomycin a patient high region. Effective dose for 90% killing (ED 90 ) values were significantly higher ( P = 0.005) 0.02) region, although there no significant differences between ED 50...