A5033662014- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Tumors and Oncological Cases
- Head and Neck Surgical Oncology
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Lymphoma Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Lung Cancer Diagnosis and Treatment
- Ethics in Clinical Research
- Esophageal Cancer Research and Treatment
- Brain Metastases and Treatment
- Ovarian cancer diagnosis and treatment
- Peptidase Inhibition and Analysis
- Cardiac tumors and thrombi
- Inflammatory Biomarkers in Disease Prognosis
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
University of Colorado Denver
2014-2024
University of Colorado Anschutz Medical Campus
2018-2024
University of Virginia
2024
University of Colorado Boulder
2023
University College Hospital
2021
University College London
2021
VA Eastern Colorado Health Care System
2016-2017
University of Colorado Cancer Center
2017
University of Iowa
2004
BACKGROUND Sinonasal malignancies are a rare and heterogeneous group of tumors for which there is paucity robust data with to guide management decisions. The authors used the National Cancer Data Base better understand presenting characteristics these compare outcomes by treatment modality. METHODS was queried sinonasal diagnosed between 2004 2012. Overall survival assessed using multivariate analyses propensity score matching. RESULTS A total 11,160 patients were identified initial...
<h3>Importance</h3> Data on adjuvant concurrent chemoradiotherapy (CRT) after resection of salivary gland carcinomas (SGCs) are limited. <h3>Objective</h3> To examine overall survival (OS) outcomes patients who receive CRT vs radiotherapy (RT) alone SGCs. <h3>Design, Setting, and Participants</h3> The National Cancer Base (NCDB), a hospital-based registry that represents 70% all cancer cases in the United States, was queried for underwent major SGCs with at least 1 high-risk feature (T3-T4...
We sought to identify genomic alterations (GA) in salivary gland adenocarcinomas, not otherwise specified (NOS), duct carcinomas (SDC), carcinoma ex pleomorphic adenoma (ca PA), and carcinoma, NOS.DNA was extracted from 149 tumors. Comprehensive profiling (CGP) performed on hybridization-captured adaptor ligation-based libraries of 182 or 315 cancer-related genes plus introns 14 28 frequently rearranged for cancer evaluated all classes GAs.A total 590 GAs were found 157 unique (mean...
The overall survival (OS) benefit of concurrent chemoradiotherapy (CRT) for head and neck squamous cell carcinoma patients older than 70 years is debated. This study examines the outcomes elderly receiving CRT versus radiotherapy (RT) alone.The National Cancer Data Base was queried with nonmetastatic oropharyngeal, laryngeal, or hypopharyngeal cancer (T3-4 N(+)). defined as chemotherapy started within 14 days initiation RT. Univariate analysis, multivariate analysis (MVA), propensity score...
Abstract Five-year survival for human papilloma virus-unrelated head and neck squamous cell carcinomas remain below 50%. We assessed the safety of administering combination hypofractionated stereotactic body radiation therapy with single-dose durvalumab (anti-PD-L1) neoadjuvantly ( n = 21) NCT03635164 ). The primary endpoint study was safety, which met. Secondary endpoints included radiographic, pathologic objective response; locoregional control; progression-free survival; overall survival....
Oral cavity squamous cell carcinoma (OCSCC) is associated with often-delayed clinical diagnosis, poor prognosis, and expensive therapeutic approaches. Prognostic accuracy important in improving treatment outcomes of patients this disease.To assess lymph node ratio (LNR) other factors estimating response to provide prognostic information helpful for decision making.A retrospective cohort study was conducted from January 1, 2000, December 31, 2015, at an academic hospital Denver, Colorado....
Objective Opioid use and abuse is a national health care crisis, yet opioids remain the cornerstone of pain management in cancer. We sought to determine risk acute chronic opioid with head neck squamous cell cancer (HNSCC) treatment. Study Design Retrospective population‐based study. Setting Surveillance, Epidemiology End Results (SEER)–Medicare database from 2008 2011. Subjects Methods In total, 976 nondistant metastatic oral cavity oropharynx patients undergoing cancer‐directed treatment...
BACKGROUND Although laryngectomy is the treatment of choice for patients with T4 larynx cancer, many are unable or unwilling to undergo and instead pursue larynx‐preservation strategies combining radiotherapy (RT) chemotherapy. Herein, authors analyzed National Cancer Data Base evaluate overall survival (OS) between treated surgical organ‐preserving modalities. METHODS The was queried diagnosed from 2004 through 2012 T4M0 laryngeal cancer who underwent either (surgery) adjuvant RT (SRT),...
Squamous cell carcinoma of the head and neck (HNSCC) represents an array disease processes with a generally unfavorable prognosis. Inflammation plays important role in tumor development response to therapy. We performed retrospective analysis HNSCC patients explore relationship lymphocyte neutrophil counts, neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific (CSS), local control (LC) distant (DC). All received definitive treatment for cancers oropharynx or larynx...
Objective: Stereotactic Body Radiotherapy (SBRT) is increasingly used to treat a variety of tumors, including head and neck squamous cell carcinomas (HNSCC) in the recurrent setting. While there are published data for re-irradiation using SBRT HNSCC, limited supporting its use as upfront treatment locally advanced disease. Study Design/Methods: Here we describe three patients who received primary their HNSCC along with review current literature discussion future pathways. Results: The cases...
Adding induction chemotherapy to concurrent and radiotherapy (RT) has generally not improved the overall survival (OS) in randomized trials of patients with head neck cancer. This failure may stem from inadequate power or inappropriate patient selection, prompting this National Cancer Data Base analysis.8031 T4 N2b N3 disease undergoing RT were divided into cohorts. Multivariate analysis was used explore association treatment identify predictors radiation dose.On multivariate incorporating...
The comparative efficacy of cisplatin (CDDP), carboplatin, and cetuximab (CTX) delivered concurrently with radiation for locally advanced oropharyngeal squamous cell carcinoma continues to be evaluated.The linked Surveillance, Epidemiology, End Results-Medicare database was used identify compare patient disease profiles, mortality, toxicity, overall cost patients oropharynx cancer undergoing definitive concurrent chemoradiation CDDP, or CTX between 2006 2011. human papillomavirus status...
Abstract Recent outcomes of immune therapies have created a paradigm shift in cancer treatment. Significant improvements cancers with clear unmet need been demonstrated most impacted by administration check point inhibitor (CPI) antibodies but not all patients benefit. mRNA-2752 is novel drug that encodes OX40L, IL-23, and IL-36γ. brings 2 approaches 1 therapy: pro-inflammatory cytokines/chemokines to ignite and/or transform an inflammatory response within the tumor microenvironment (TME),...