A5080109606- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Lung Cancer Research Studies
- Ion channel regulation and function
- Inflammatory Biomarkers in Disease Prognosis
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Amyotrophic Lateral Sclerosis Research
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- CAR-T cell therapy research
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Ear and Head Tumors
- Pharmacy and Medical Practices
- ECG Monitoring and Analysis
- Trauma Management and Diagnosis
- Medical Imaging and Analysis
- Lymphoma Diagnosis and Treatment
Moores Cancer Center
2019-2023
University of California, San Diego
2019-2023
University of Colorado Denver
2013-2018
Roosevelt Institute
2018
University of Denver
2014-2018
Significance Maximum heart rate (mHR) declines with age, contributing to the reduced aerobic capacity of elderly. A parallel reduction in "intrinsic rate" (which is measured during autonomic blockade) underlies decline mHR, and indicates that pacemaker function sinoatrial node compromised aging. In this study we demonstrate slower rates elderly result from depressed spontaneous activity individual myocytes (SAMs). Patch-clamp electrophysiology revealed aged SAMs have slowed AP firing rates,...
Oral cavity squamous cell carcinoma (OCSCC) is associated with often-delayed clinical diagnosis, poor prognosis, and expensive therapeutic approaches. Prognostic accuracy important in improving treatment outcomes of patients this disease.To assess lymph node ratio (LNR) other factors estimating response to provide prognostic information helpful for decision making.A retrospective cohort study was conducted from January 1, 2000, December 31, 2015, at an academic hospital Denver, Colorado....
Minority race and lower socioeconomic status are associated with rates of opioid prescription undertreatment pain in multiple noncancer healthcare settings. It is not known whether these differences prescribing exist among patients undergoing cancer treatment.
Squamous cell carcinoma of the head and neck (HNSCC) represents an array disease processes with a generally unfavorable prognosis. Inflammation plays important role in tumor development response to therapy. We performed retrospective analysis HNSCC patients explore relationship lymphocyte neutrophil counts, neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific (CSS), local control (LC) distant (DC). All received definitive treatment for cancers oropharynx or larynx...
Background Radiation recall pneumonitis (RRP) is a poorly understood clinical syndrome in which patients develop radiation triggered by systemic agent, often years after the completion of therapy. Immune checkpoint blockade agents have only recently been posited as trigger for RRP. Here, we present three cases immunotherapy-induced Case Presentation Our first patient was diagnosed with primary lung adenocarcinoma, and 4.5 completing therapy developed symptomatic RRP immediately following...
Objective: Stereotactic Body Radiotherapy (SBRT) is increasingly used to treat a variety of tumors, including head and neck squamous cell carcinomas (HNSCC) in the recurrent setting. While there are published data for re-irradiation using SBRT HNSCC, limited supporting its use as upfront treatment locally advanced disease. Study Design/Methods: Here we describe three patients who received primary their HNSCC along with review current literature discussion future pathways. Results: The cases...
B cells play a key role in outcomes of cancer patients and responses to checkpoint blockade immunotherapies. However, the effect radiation therapy on cell populations is poorly understood. Here we characterize effects development, survival, phenotype physiological B-cell subsets.Naïve immunized tumor bearing nontumor mice were treated with large-field or focal stereotactic distinct subsets varying developmental stages analyzed by flow cytometry real-time reverse transcription polymerase...
Depletion of the endogenous antioxidant, glutathione (GSH), underlies progression devastating neurodegenerative disease, amyotrophic lateral sclerosis (ALS). Thus, strategies aimed at elevating GSH may yield new therapeutics for ALS. Here, we investigated effects a unique non-denatured whey protein supplement, Immunocal®, in transgenic Gly position 93 to Ala (G93A) mutant hSOD1 (hSOD1G93A) mouse model Immunocal® is rich precursor, cystine, and therefore capable bolstering content. Transgenic...
Abstract Background Best‐practice guidelines for head and neck cancer patients advise postoperative radiation therapy (PORT) initiation within 6 weeks of surgery. We report our institutional experience improving timeliness adjuvant in free‐flap patients. Methods Thirty‐nine met inclusion criteria the 2017–2019 study period. divided into “Early” ( n = 19) “Late” 20) time‐period groups to compare performance over time. The primary endpoint was time PORT initiation, with success defined as...
Abstract Background Optimizing the therapeutic ratio for radiation therapy (RT) in head and neck squamous cell carcinoma (HNSCC) is uniquely challenging owing to high rates of early late toxicity involving nearby organs at risk. These toxicities have a profound impact on treatment compliance quality life. Emerging evidence suggests that RT dose alone cannot fully account variable severity RT-related adverse events (rtAEs) observed HNSCC patients. Next-generation sequencing has become an...
Oxidative stress is a principal mechanism underlying the pathophysiology of neurodegeneration. Therefore, nutritional enhancement endogenous antioxidant defenses may represent viable treatment option. We investigated neuroprotective properties unique whey protein supplement (Immunocal®) that provides an essential precursor (cystine) for synthesis antioxidant, glutathione (GSH). Primary cultures rat cerebellar granule neurons (CGNs), NSC34 motor neuronal cells, or HT22 hippocampal cells were...
The molecular mechanisms leading to motor neuron death in amyotrophic lateral sclerosis (ALS) are unknown; however, several studies have provided evidence of a central role for intrinsic apoptosis. Bcl-2 homology-3 domain (BH3)-only proteins pro-apoptotic members the family whose enhanced expression acts as trigger apoptotic cascade. Here, we compared relative BH3-only spinal cord end-stage G93A mutant SOD1 mice age-matched wild-type (WT) mice. Large alpha neurons lumbar sections both WT and...
Abstract Purpose The purpose of this study was to evaluate if HPV status serves as an independent predictor early and late dysphagia outcomes when considered alongside standard patient characteristics dose metrics for head neck cancer patients treated with radiotherapy. Methods materials age, sex, smoking history, type (oropharyngeal vs non-oropharyngeal), status, were obtained 99 retrospective at our clinic Additionally each patient, the mean radiation pharynx, superior/middle/inferior...
During a course of radiation therapy, anatomical changes such as decrease in tumour size or weight loss can trigger the need for repeating computed tomography (CT) simulation scan order to generate new treatment plan. This adaptive approach requires separate appointment an additional CT which generates burden, cost, and exposure patients.
Abstract Background Image guidance in radiation oncology has resulted significant improvements the accuracy and precision of therapy (RT). Recently, resolution quality cone beam computed tomography (CBCT) for image increased so that tumor masses lymph nodes are readily detectable measurable. During treatment head neck squamous cell carcinoma (HNSCC), on-board CBCT setup imaging is routinely obtained; however, this data not utilized to predict patient outcomes. Here, we analyzed whether...
Local recurrence following definitive chemoradiation in cervical cancer ranges from 5-18%. Currently, there are limited options available for patients recurring para-aortic or iliac lymph nodes. We present two cases of reirradiation non-central recurrences with intensity-modulated radiotherapy (IMRT). Both achieved a complete response manageable short-term toxicities and no late adverse effects follow-up over one year three years after reirradiation. While further is needed, IMRT feasible...