A5030393984- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Genetic Neurodegenerative Diseases
- Advanced Photocatalysis Techniques
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- vaccines and immunoinformatics approaches
- Parasitic infections in humans and animals
- Carbon and Quantum Dots Applications
- Genetics and Neurodevelopmental Disorders
- Advanced Nanomaterials in Catalysis
- Transgenic Plants and Applications
- Amyotrophic Lateral Sclerosis Research
- TiO2 Photocatalysis and Solar Cells
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Calcium signaling and nucleotide metabolism
- RNA modifications and cancer
- Nanocluster Synthesis and Applications
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Mosquito-borne diseases and control
Indian Institute of Technology Jodhpur
2016-2025
Jaypee Institute of Information Technology
2024
Maharana Pratap University of Agriculture and Technology
2022-2023
Jožef Stefan Institute
2023
Pondicherry Institute of Medical Sciences
2017-2022
Madras Medical Mission
2022
Bilkent University
2019-2021
Jawaharlal Nehru University
2021
Inha University
2021
National Institute for Research in Tribal Health
2021
Dengue is considered as a major health issue which causes number of deaths worldwide each year; tropical countries are majorly affected by dengue outbreaks. It life threatening because, since many decades not single effective approach for treatment and prevention has been developed. Therefore, to find new preventive measure, we used immunoinformatics approaches develop multi-epitope based subunit vaccine can generate various immune responses inside the host. Different B-cell, T
Carbon cloths are the important materials composed of woven carbon fibres having diameters in range 5–10 μm. These have been investigated for innumerable applications such as supercapacitors (symmetric and asymmetric), batteries, solar cells, catalysis. They found to be best supports supercapacitive by providing high surface area, conductivity flexibility compared much widely used substrate Ni foam 1D Fe nanowires. High area enable ion diffusion cause decrease charge transfer resistance,...
Nucleic acid G-quadruplex structure (G4) Interacting Proteins DataBase (G4IPDB) is an important database that contains detailed information about proteins interacting with nucleic acids forms structures. G4IPDB the first provides comprehensive this interaction at a single platform. This more than 200 entries details of such as protein name and their synonyms, UniProt-ID, source organism, target its sequences, ∆Tm, binding/dissociation constants, gene name, FASTA sequence, residue in protein,...
The Zika virus is a rapidly spreading Aedes mosquito-borne sickness, which creates an unanticipated linkage birth deformity and neurological turmoil. This study represents the use of combinatorial immunoinformatics approach to develop multiepitope subunit vaccine using structural nonstructural proteins virus. designed consists cytotoxic T-lymphocyte helper epitopes accompanied by suitable adjuvant linkers. presence humoral immune response specific B-cell was also confirmed epitope mapping...
MXenes, in view of their extraordinary properties, such as layered structure, metal-like high thermal stability, good mechanical strength, conductivity, presence active sites, and terminal functional groups, have received the utmost importance outstanding materials for energy storage applications supercapacitors metal-ion batteries. Even though MXenes promising Li-ion batteries due to capacity, performance is not satisfactory compared presently used state-of-the-art electrodes. Pure suffer...
Aspirin and other nonsteroidal anti-inflammatory drugs inhibit cell proliferation induce apoptosis in various cancer lines, which is considered to be an important mechanism for their anti-tumor activity prevention of carcinogenesis. However, the molecular mechanisms through these compounds are not well understood. Here we have found that aspirin treatment mouse Neuro 2a cells impaired proteasome function caused severe mitochondrial abnormalities. Treatment with lead a dose- time-dependent...
Cells are equipped with an efficient quality control system to selectively eliminate abnormally folded and damaged proteins. Initially the cell tries refold unfolded proteins help of molecular chaperones, failure leads their degradation by ubiquitin proteasome system. But how this proteolytic machinery recognizes is poorly understood. Here, we report that E6-AP, a HECT domain family ligase implicated in Angelman syndrome, interacts substrate binding Hsp70/Hsc70 chaperones promotes chaperone...
Abstract Piperine, a naturally occurring alkaloid, is well known as anti-oxidant, anti-mutagenic, anti-tumor and anti-proliferative agent. Piperine exerts such pharmacological activities by binding or interacting with various cellular targets. Recently, the first report for interaction duplex DNA has been published last year but its G-quadruplex structures not studied yet. Herein, we time of structures. Comprehensive biophysical techniques were employed to determine basis complex formed...