A5083341741- Mosquito-borne diseases and control
- vaccines and immunoinformatics approaches
- HIV Research and Treatment
- Computational Drug Discovery Methods
- Viral Infections and Vectors
- Crystallization and Solubility Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Nanoparticles: synthesis and applications
- X-ray Diffraction in Crystallography
- Malaria Research and Control
- COVID-19 Clinical Research Studies
- Papaya Research and Applications
ICMR-National Institute of Virology
2022-2023
The chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes mosquitoes . There are no licenced antivirals or vaccines for treatment prevention. Drug repurposing approach has emerged as a novel concept to find alternative uses of therapeutics battle pathogens. In the present study, anti CHIKV activity fourteen FDA-approved drugs was investigated in vitro and silico approaches. Focus-forming unit assay, immunofluorescence test, quantitative RT-PCR assay were used assess inhibitory...
The rising incidence of dengue virus (DENV) infections in the tropical and sub-tropical regions world emphasizes need to identify effective therapeutic drugs against disease. Repurposing has emerged as a novel concept combat pathogens. In this study, we employed transcriptomics-based bioinformatics approach for drug identification DENV. Gene expression omnibus datasets from patients with different grades disease severity healthy controls were used differentially expressed genes cases, which...
Abstract A surge in chikungunya was observed during 2020‐21 Pune district of Maharashtra, India. Whole genome sequencing and phylogenetic analysis 21 samples/sequences revealed them as Indian ocean lineage East Central South African genotype. Two distinct sequence clusters were found to circulate 2020‐21; one with E1:K211E E2:V264A mutations while the other had E1:I317V mutation along E2: V264A mutations. The former, predominant cluster ( n = 18), clustered virus (CHIKV) strains pre 2014...