A5056902765- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Drug Solubulity and Delivery Systems
- X-ray Diffraction in Crystallography
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Nanoparticle-Based Drug Delivery
- Chemical Thermodynamics and Molecular Structure
- Advancements in Transdermal Drug Delivery
- Enzyme Structure and Function
- Protein purification and stability
- Crystal structures of chemical compounds
- Pesticide Residue Analysis and Safety
- Synthesis and properties of polymers
- Spectroscopy and Chemometric Analyses
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Injection Molding Process and Properties
- Mesoporous Materials and Catalysis
- Microencapsulation and Drying Processes
- Thermal and Kinetic Analysis
- Medication Adherence and Compliance
- Nonlinear Optical Materials Research
National Institute of Pharmaceutical Education and Research
2012-2021
National Institute of Pharmaceutical Education and Research
2011-2021
University of Hyderabad
2016-2020
The aim of this study was to improve the dissolution rate poorly soluble drug valsartan by delivering as a liquisolid compact. Liquisolid compacts were prepared using propylene glycol solvent, Avicel PH102 carrier, and Aerosil 200 coating material. crystallinity newly formulated interaction between excipients examined X-ray powder diffraction Fourier-transform infrared spectroscopy, respectively. studies for formulation marketed product carried out at different pH values. results showed no...
Supersaturated drug delivery systems are generally developed for improving solubility and dissolution of poorly soluble drugs.
This study presents novel self-nanoemulsifying drug delivery system potential of oral delivering which leads poorly aqueous soluble glimepiride.The objective this was to prepare solid (S-SNEDDS) for the improved glimepiride and evaluate its therapeutic efficacy in albino rabbits.The droplet size analyses revealed a less than 200 nm. The state characterization S-SNEDDS by scanning electron microscopy (SEM), X-ray powder diffraction differential calorimetry (DSC) absence crystalline S-SNEDDS....
Cocrystallization is a rational selection crystal engineering approach for the development of novel solid forms with enhanced physicochemical and mechanical properties.
Fast disintegrating films of levocetirizine dihydrochloride useful for the treatment acute allergic rhinitis and chronic urticaria have been developed by using taste masking ability cyclodextrins. The fast were prepared solvent casting method. contained water-soluble polymers such as Kollicoat IR or pullulan, aspartame sucralose sweeteners pre-gelatinized starch disintegrant. Levocetirizine was incorporated into these in-situ complex formation with hydroxy propyl beta-cyclodextrin. optimized...
Syringic acid (SYRA) is a potential antioxidant used in traditional Chinese medicine and an emerging nutraceutical. Current reports claim its anti-angiogenic, anti-glycating, anti-hyperglycaemic, neuroprotective, memory-enhancing properties various animal models. To date, SYRA crystal structure has not been elucidated, no engineering studies have reported. This study the of for first time along with nicotinamide (SNCT-E) urea (SU-EA-M) co-crystals. All forms were successfully characterized...
Riluzole is a drug, used to slow the course of amyotrophic lateral sclerosis. Due its unique structure and functionalities, it able form both salts cocrystals. This BCS class II drug with poor solubility causes hepatotoxicity which limits application. The present study aims toward development novel solid forms riluzole address said limitations. Apart from this, an attempt has been made develop prediction model using software tools identify appropriate synthons for formation It was observed...
Albendazole (ABZ) is a broad spectrum anthelminthic drug and in the WHO list of essential medicines. It "brick dust" with very poor water solubility (0.2 pg ml−1 at 25 °C). In present study, crystal engineering ABZ was carried out using two different techniques: solvent recrystallization spherical agglomeration. All modified habits have shown improved dissolution flow properties. Spherical agglomerates HPC as binder 5.60 fold enhancement efficiency end 6 h when compared to ABZ. The showed...
The present study reports an intriguing case of agglomeration platy crystals into spheroids. Etodolac a nonsteroidal anti-inflammatory drug is mainly used for rheumatoid arthritis, with emerging applications in management prostate cancer and Alzheimer's disease. It BCS class II poor flow compressibility issues. Recrystallization using various solvents resulted crystals. Different polymers like hydroxypropyl cellulose (HPC), methylcellulose (HPMC), polyvinylpyrrolidone (PVP), copolymers...