Novel crystalline adducts of clotrimazole with pharmaceutically acceptable coformers were prepared. Five salts and two cocrystals the antimycotic drug (CLT) crystallized carboxylic acid adipic (ADA), 2,5-dihydroxybenzoic (25DHBA), 2,4,6-trihydroxybenzoic (246THBA), p-coumaric (PCA), caffeic (CFA), maleic (MA), suberic (SBA). Molecular overlay diagram in four (CLT–25DHBA, 1:1; CLT–246THBA, CLT–PCA, CLT–CFA–ANI, 1:1:1) CLT–ADA (1:0.5) cocrystal showed conformational flexibility phenyl rings...

The trimorphic cocrystals of celecoxib with δ-valerolactam contain sulfonamide dimers and catemers together carboxamide dimers, whereas the caprolactam cocrystal is sustained by a SO2N–H⋯H–NOC heterosynthon. alternation synthons even–odd ring coformers offers crystal engineering approach to sulfonamide–carboxamide cocrystals.

Syringic acid (SYRA) is a potential antioxidant used in traditional Chinese medicine and an emerging nutraceutical. Current reports claim its anti-angiogenic, anti-glycating, anti-hyperglycaemic, neuroprotective, memory-enhancing properties various animal models. To date, SYRA crystal structure has not been elucidated, no engineering studies have reported. This study the of for first time along with nicotinamide (SNCT-E) urea (SU-EA-M) co-crystals. All forms were successfully characterized...

The design of novel supramolecular synthons for functional groups relevant to drugs is an essential prerequisite applying crystal engineering in the development pharmaceutical cocrystals. It has been convincingly shown over past decade that molecular level control and modulation can influence physicochemical properties drug Whereas considerable advances have reported on cocrystals carboxylic acids carboxamide groups, sulfonamide group, which a cornerstone sulfa drugs, relatively unexplored...

Polymorphs of the dichloro derivative N -salicylideneaniline exhibit mechanical responses such as jumping (Forms I and III) exploding (Form II) in its three polymorphs. The molecules are connected via amide N—H...O dimer synthon C—Cl...O halogen bond crystal structures. A fourth high-temperature Form IV was confirmed by variable-temperature single-crystal X-ray diffraction at 180°C. behaviour exhibited polymorphic crystals Forms III is due to layered sheet morphology transmission thermal...

Solvent drop grinding experiments on riluzole, an organofluorine drug, with different carboxylic acids (mono and di) pyridine derivatives, resulted in the formation of 10 co-crystals, one polymorph a co-crystal, salt. The crystal packing is primarily stabilized via strong N–H···O, O–H···N, O–H···O, N–H···N hydrogen bonds, addition to secondary interactions type C–H···F/O S···F intermolecular contacts. melting point new crystalline phases was observed be present range 90–140 °C which closely...

Niflumic acid (NFA) is a nonsteroidal anti-inflammatory drug (NSAID) classified under the BCS (Biopharmaceutical Classification System) Class II category of poor aqueous solubility and high permeability. In an attempt to improve physicochemical properties NFA, particularly dissolution rate by cocrystallization salt formation, cocrystals NFA were prepared with caprolactam (CPR, 1:1) 2-hydroxy pyridine (2HP, as well salts piperazine (PIP, 1:0.5), benzenesulfonic (BSA, 1:1), benzyl amine (BZA,...

Lamotrigine (L) is a known drug in the treatment of epilepsy and bipolar disorder. Due to its unique structure functionalities, L able form both salts cocrystals. The present study reports ionic, neutral, hybrid crystalline forms with improved material properties modified release rates. Novel cinnamic acid (CA), ferulic (FRA), salicylic (SAC), vanillin (VN) were successfully prepared characterized using single crystal XRD, SEM, FT–IR, DSC, TGA, powder XRD. LCA LVN crystallized P21/c space...

Acedapsone is a long acting prodrug of Dapsone, the diacetyl derivative diaminophenyl sulfone. It exhibits superior bioavailability compared to parent drug. Dapsone occupies preeminent position in treatment leprosy since 1940s. Surprisingly no X-ray crystal structure or polymorphs acedapsone are reported. Five novel reported (I–V) which forms I and II characterized by single diffraction. These were crystallized from solution, slow cooling melt, spray-drying powder. Solution crystallization...

Novel crystalline forms of etoricoxib (ETR) with pharmaceutically acceptable coformers (generally regarded as safe, GRAS), such glutaric acid (1 : 1), adipic (2 suberic and caprolactam, were co-crystallized. The solid prepared from ETR hemihydrate form I characterized by powder XRD, DSC, IR, finally confirmed single crystal X-ray diffraction. exchange water an organic coformer in the structure is explained lattice energy calculations.

The design and synthesis of mechanically responsive materials is interesting because they are potential candidates to convert thermal energy into mechanical work. Reported in this paper thermosalient effects a series halogen derivatives salinazids. chloro derivative, with higher electronegativity weaker inter-halogen bond strength (Cl⋯Cl) exhibits an excellent response, whereas the response iodo derivative stronger I⋯I bonding. 3,5-Di-chloro-salinazid (Compound-A) exists three polymorphic...

Temozolomide (TMZ) is a frontline prodrug for the treatment of glioblastoma multiforme (brain cancer) approved by US-FDA in 1999. A limitation with this otherwise potent and selective DNA alkylating agent degradation to inactive product 5-aminoimidazole-4-carboxamide (AIC) incipient hydrolysis during storage. This transformation not only makes drug less effective (due active drug), but also causes discoloration from white pink tan brown colour AIC contamination), which can make patients...

Celecoxib (CEL) is a well-known nonsteroidal anti-inflammatory drug (NSAID) and selectively used from the cocxib family. It specific COX-2 inhibitor for pain inflammation without inhibiting COX-1. A major downside of this popular NSAID its poor aqueous solubility (9 mg L–1), which limits bioavailability (40%). Several methods were attempted in recent past to overcome issues drug. metastable form-IV showed four times greater improved compared commercial CEL form-III. Cocrystal with...