A5058711098- Aldose Reductase and Taurine
- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Psoriasis: Treatment and Pathogenesis
- Synthesis and Reactivity of Heterocycles
- Phytochemistry and Biological Activities
- Genomics, phytochemicals, and oxidative stress
- Synthesis and Characterization of Heterocyclic Compounds
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Natural Antidiabetic Agents Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Wnt/β-catenin signaling in development and cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Ethnobotanical and Medicinal Plants Studies
- Axon Guidance and Neuronal Signaling
- Bioactive natural compounds
- Curcumin's Biomedical Applications
- Drug-Induced Hepatotoxicity and Protection
- Cancer Mechanisms and Therapy
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
National Institute of Pharmaceutical Education and Research
2020-2025
University of Pittsburgh
2025
Novartis (India)
2023
Background & AimsThe mechanism behind the progressive pathological alteration in MASLD/MASH-associated HCC is poorly understood. In present study, we have investigated role of polyol pathway enzyme, AKR1B1 metabolic switching associated with MASLD/MASH and progression HCC.MethodsThe expression tissue plasma patients MASLD/MASH, HCC, diabetes mellitus were estimated. The vitro was assessed through media conditioning, lentiviral transfection, pharmacological probes. proteomic metabolomic...
Design, synthesis, characterization of a series imidazo[1,5- ]pyridine-chalcones and evaluated their cytotoxicity. Apoptotic induction, ROS-mediated mitochondrial damage, immuno-fluorescence, microtubule disruption docking were also studied.
Abstract Background: pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with only a 12% five-year survival rate. The complex nature PDAC limits treatment options, highlighting need to identify novel therapeutic targets. Males are more likely develop than females, so we performed an initial screening estrogen-metabolizing enzymes associated development. Interestingly, Estrogen sulfotransferase (SULT1E1 or EST) was found be over-expressed in compared normal tissues, and...
Litsea salicifolia Roxb. (LS) is a pioneer medicinal plant that can be found in tropical and subtropical countries like India, China Japan. LS traditionally used for treating chronic pulmonary inflammatory diseases asthma wound healing. Also, contains an essential oil with powerful anti-oxidant excite-repellency properties. However, no research findings have been reported about its protective activity on disease rheumatoid arthritis (RA) till yet. This study aims to investigate the...
Introduction Gastric carcinoma (GC) remains a therapeutic challenge despite having many potent drugs to treat. Various studies emphasized the role of dysregulated Wnt/β-catenin pathway in cancer. In present study, we examined anti-cancer effect Niclosamide and its on β-catenin human gastric cell lines. Methods Cytotoxicity compound cancer line was assessed by MTT viability assay, cycle analysis, apoptosis assay done using standard kits Muse™ Cell Analyser. Reactive oxygen species (ROS)...
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Accumulating evidence attributes the role of aldose reductase (AR) in modulating ROS and inflammation which are main factor responsible for cancer progression drug resistance. Epalrestat is only AR inhibitor being used Asian countries. It did not make it to markets USA Europe due marginal efficacy as an antioxidant anti-inflammatory agent owing difficulty reaching intracellular targets. In our previous studies, we attempted synthesize epalrestat analogs reported that compound...
Colorectal cancer (CRC) is among the leading three diseases with higher death rates worldwide, an expected 2.2 million new cases continuously in 2030. The expanding utilization of common plant-inferred parts, investigating counter proliferative impacts phytochemicals progressively picking up significance planning anticancer medications. This study aimed to examine effect methanolic extracts Entada phaseoloides (MEEP) on apoptotic pathway human colon carcinoma cells (HT-29 cells). MTT assay...
The development of resistance is one the major complications faced by an oncologist for cancer treatment. Autophagy plays a crucial role in driving this against most antineoplastic therapies. evolutionarily conserved autophagy process meant quality control cellular organelles and protein complexes overwhelmed proliferative signals from various carcinogens. This leads to accumulation defective oncogenic proteins leading carcinogenesis. As tumor proliferates grows size, it reboots its pathways...
Abstract Objective Emergent epidemiological evidence suggests that the progression of NAFLD/NASH-associated HCC positively correlates with patient's glycemic index. However, mechanism behind this progressive pathological alteration is poorly understood. It has shown polyol pathway master regulator, AKR1B1 over-expressed in hyperglycemia and responsible for most diabetic complications. Hence present study, we have investigated role metabolic switching associated NAFLD/NASH HCC. Methods The...
In continuation of our efforts to develop new anticancer compounds, a series imidazo[1,5-a]pyridine-chalcone conjugates were designed, synthesized, characterized, and evaluated for their cytotoxicity against five human cancer cell lines i.e., breast (MDA-MB-231), colon (RKO), bone (Mg-63), prostate (PC-3), liver (HepG2) also normal line (HEK). Among the synthesized compounds two exhibited promising MDA-MB-231 with IC50 Values 4.23±0.25 3.26±0.56 µM.We studied apoptotic induction using...