A5025177174- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques
- Organoselenium and organotellurium chemistry
- Inflammatory mediators and NSAID effects
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Plant chemical constituents analysis
- Chemical synthesis and alkaloids
- Advancements in Transdermal Drug Delivery
- Plant biochemistry and biosynthesis
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Computational Drug Discovery Methods
- Chemical Synthesis and Reactions
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactivity Studies
- Organic and Inorganic Chemical Reactions
- Berberine and alkaloids research
- Microbial metabolism and enzyme function
- Biological and pharmacological studies of plants
- Advanced Drug Delivery Systems
- Tuberculosis Research and Epidemiology
National Institute of Pharmaceutical Education and Research
2021-2024
National Institute of Pharmaceutical Education and Research
2022-2024
Panjab University
2013-2017
International Medical University
2014
Abstract The ever‐growing interest for organoselenium compounds amongst the chemists has made commendable impact in field of medicinal chemistry, material chemical biology and biochemistry. Researchers have progressively contributed development over years which been periodically reviewed. On similar note, this review attempts at providing an overview recent advances chemistry while covering their catalytic indulgence different transformational approaches, role asymmetric synthesis, synthetic...
Journal of Computational Biophysics and ChemistryAccepted Papers No Access'Dawa-ul-kurkum', a Potential Anti-diabesity Polyherbal Formulation: Phyto-metabolomics, Network Pharmacology, Molecular Docking Simulation studies supported by in vitro ActivitySibu Sen, Nabarun Mukhopadhyay, Srishti Singh, Venkata Rao Kaki, Ravi Adinarayan Somabattini, Satheesh Kumar Nanjappan, Amol G. DikundwarSibu Mukhopadhyay Search for more papers this author , Singh Kaki Somabattini Nanjappan Dikundwar...
Abstract A new synthetic method has been established to synthesize α-carbolines through the reaction of electrophilic azaindoles with ambiphilic alkylidene malononitriles. The versatility this approach was explored by using various malononitriles, and also conducting nitrogen migration on azaindole. This enables simultaneous introduction diverse functional groups, such as amine, nitrile, aryl, onto benzene ring a carboline scaffold. As scaffold putatively shows antiproliferative other...
Abstract Thienopyrimidines are an emerging class of fused pyrimidines due to their broad spectrum pharmacological properties, including antimicrobial, anti-inflammatory, antimalarial, anticancer, etc. The anticancer activity these compounds has been mechanistically proven via the inhibition validated drug targets, such as EGFR, VEGFR-2, PI3K, and c-kit. In this research article, we designed synthesized new 4-amino-substituted...
Abstract We report a metal-free protocol for the amidation and selenoamidation of 2-methylquinolines by using selenium dioxide as key reagent. This method offers several advantages, including ease operation, short reaction time (15 min), moderate to excellent yields (50–90%). The demonstrates broad substrate tolerance, various secondary amines 2-methyl heterocycles such pyridine benzothiazole. applicability was further highlighted through late-stage functionalization ciprofloxacin, yielding...
Traumatic brain injury (TBI) is known as a silent epidemic that causes many deaths and disabilities worldwide. We examined the response of oxyberberine (OBB) in lipopolysaccharide-stimulated BV2 microglial cells controlled-cortical impact (CCI) mouse model TBI.We synthesized OBB from berberine, also prepared OBB-nanocrystals (OBB-NC). Male C57BL/6 mice were used for CCI surgery, post-CCI neurobehavioral deficits assessed 1 h after through 21 days post-injury (dpi).OBB treatment reduced...
Abstract A simple, efficient, and environmental friendly procedure was developed based on the Gewald reaction for synthesis of 2-aminothiophenes using a basic ionic liquid [bmIm]OH as both catalyst solvent. Besides being green protocol, method offers advantages successful variety alkyl, aryl, alkoxy, alkylamino-2-aminothiophenes in good yields.
Abstract The phenanthrene nucleus is extensively found in diverse natural products and its versatility not just limited to pharmaceutically beneficial molecules but has proved efficient the development synthesis of dyes, plastics, pesticides explosives. Such a relevant attracted researchers probe into construction nucleus. past two decades have witnessed continuous efforts this direction with exploration various synthetic strategies enabling access privileged core. review focuses on bringing...
Anthocyanins are flavonoid containing polyphenolic phytochemicals. They widely present in plants and accounts for different color shades displayed by the plant organs. A broad range of health-revitalizing effects is attributed to anthocyanins, constituting a vital part human diet. also accountable ameliorating detrimental various lifestyle diseases, including cancer, cardiovascular disorders, neurological etc. These beneficial impacts highly depend on bioavailability governed their...
Abstract Chronic kidney disease is one of the major health burdens affecting a considerable number people worldwide. The aberrant regulation lysyl oxidase (LOX) family enzymes results in establishment dense extracellular matrix (ECM). Since, LOX need copper (Cu) for their proper catalytic activity; present study investigated efficacy chelator, disulfiram (DSF) renal fibrosis. Antifibrotic activity DSF was epithelial cells stimulated by transforming growth factor‐β1 (5 ng/ml) as well two...
Abstract A simple tert ‐butyl hydroperoxide (TBHP)‐mediated method has been developed to construct selenated oxazolines/thiazolines under microwave irradiation. The selenocyclization of N ‐allylbenzamides/benzthioamides could be achieved owing the addition an active electrophilic selenium species, generated in situ from diphenyl diselenide on reacting with TBHP, at their olefinic site. reaction mechanism was confirmed by intercepting and characterizing all proposed intermediates ESI‐QTOF‐MS...
Matrix Metalloproteinases-9 (MMP-9) is one of the important targets that play a vital role in various diseases such as cancer, Alzheimer's, arthritis, etc. Traditionally, MMP-9 inhibitors have been unable to achieve selectivity get around this target; thereby, novel mechanisms inhibition activated zymogen (pro-MMP-9) discovered. The JNJ0966 was few compounds attained requisite by inhibiting activation (pro-MMP-9). Since JNJ0966, no other small molecules identified. Herein, extensive silico...
Breast cancer is one of the most high-profile malignant diseases in modern society. Among postmenopausal women affected by disease, a substantial portion has breast tumors that are estrogen-receptor positive. A common therapeutic intervention for this type through endocrine therapy. Endocrine agents can act either diminishing availability or inhibiting binding estrogens to ER. Aromatase catalyzes conversion androgens final step biosynthesis and therefore an attractive target inhibition....
Abstract Background Murraya koenigii (L.) Spreng. (Rutaceae) is an important medicinal plant in natural products research for its diverse pharmacological activities. Carbazole alkaloids were the major classes of phytoconstituents obtained from different parts this plant, such as leaves, stems, and roots. Mahanimbine koenimbine are two carbazole M. known their anti-cancer, anti-oxidant, anti-diarrhoeal agents, etc. Standardization plays a vital role herbal drug industry maintaining quality,...