A5072349763- Quinazolinone synthesis and applications
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Synthesis and biological activity
- Vitamin C and Antioxidants Research
- Synthesis and Characterization of Heterocyclic Compounds
- SARS-CoV-2 and COVID-19 Research
- Phytochemistry and Bioactivity Studies
- Crystallization and Solubility Studies
- Cannabis and Cannabinoid Research
- vaccines and immunoinformatics approaches
- X-ray Diffraction in Crystallography
- Drug Transport and Resistance Mechanisms
- Synthesis and Biological Evaluation
- Pediatric Hepatobiliary Diseases and Treatments
- Cholesterol and Lipid Metabolism
- Plant chemical constituents analysis
- Kidney Stones and Urolithiasis Treatments
- Liver Disease Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Protein Degradation and Inhibitors
- Catalytic Cross-Coupling Reactions
- Phytochemical compounds biological activities
- Multicomponent Synthesis of Heterocycles
- Viral Infections and Outbreaks Research
Education Trust
2025
The University of Queensland
2025
National Institute of Pharmaceutical Education and Research
2024
Hebrew University of Jerusalem
2023-2024
National Institute of Pharmaceutical Education and Research
2021-2024
Birla Institute of Technology and Science, Pilani
2022-2023
Indian Institute of Chemical Biology
2019-2021
Abstract In the face of escalating challenges microbial resistance strains, this study describes design and synthesis 5‐({1‐[(1 H ‐1,2,3‐triazol‐4‐yl)methyl]‐1 ‐indol‐3‐yl}methylene)thiazolidine‐2,4‐dione derivatives, which have demonstrated significant antimicrobial properties. Compared with minimum inhibitory concentrations (MIC) values ciprofloxacin on respective compounds 5a , 5d 5g 5l 5m exhibited potent antibacterial activity MIC ranging from 16 to 25 µM. Almost all synthesized showed...
Abstract The ever‐growing interest for organoselenium compounds amongst the chemists has made commendable impact in field of medicinal chemistry, material chemical biology and biochemistry. Researchers have progressively contributed development over years which been periodically reviewed. On similar note, this review attempts at providing an overview recent advances chemistry while covering their catalytic indulgence different transformational approaches, role asymmetric synthesis, synthetic...
The decoction of the whole plant Enhydra fluctuans is used ethno medicinally by various tribes for treatment kidney stones and urinary problems. However, no scientific studies were carried out to delineate its influence on stone formation crystallisation. Hence, present study proposed investigate effect aqueous extract in vitro crystallisation calcium oxalate. also evaluated. silico metabolites with target proteins renal oxalate matrix. material was subjected obtain an extract....
The endocannabinoid system consists of several phytocannabinoids, cannabinoid receptors, and enzymes that aid in numerous steps necessary to manifest any pharmacological activity. It is well known the inhibits pathogenesis inflammatory autoimmune disease rheumatoid arthritis (RA). To best our knowledge, no research has been done explains network-pharmacology-based anti-rheumatic processes by focusing on system. Therefore, purpose this study further understanding signaling pathways,...
Owing to the significant contribution of three-dimensional (3D) field-based QSAR toward hit optimization and accurately predicting activities small molecules, herein, 3D-QSAR, in vitro antimicrobial, molecular docking, pharmacophore modeling studies all isolated (R/S)-2-thioxo-DHPM-5-carboxanilides exhibiting antimicrobial activity were carried out. The screening process was performed using 46 compounds, best-scoring model with top statistical values considered for bacterial fungal targets...
A novel series of indolyl oxoacetamide-quinazolinone hybrid analogues (9aa–9df) were designed, synthesized, and evaluated for their in vitro pancreatic lipase (PL) inhibitory potential that may lead to efficient anti-obesity agents.
In view of the ethno medicinal use Enhydra fluctuans for treatment kidney stones; present study aimed to elucidate molecular mechanisms involved in amelioration nephrolithiasis through a network pharmacology approach. The phytoconstituents were queried DIGEP-Pred identify regulated proteins. modulated proteins then enriched STRING predict protein-protein interactions and probably pathways traced Kyoto Encyclopedia Genes Genomes. Further, was constructed using Cytoscape ver 3.5.1. Results...
Plumbago zeylanica is an important plant used in the Ayurvedic system of medicine for treatment hemorrhoids or piles. Despite its clinical uses, molecular mechanism, ameliorating not yet explored. Hence, present study evaluated plausible mechanisms P. using network pharmacology and other silico analysis. Network was carried out by protein, GO, KEGG enrichment Further ADME/T, docking dynamics studies resultant bioactive compounds with regulated proteins were evaluated. Results analysis...
In our preliminary
Abstract We represent here, a divergent approach for the total synthesis of (±)‐Mahanine and twelve other naturally occurring carbazole alkaloids. Remarkably, we have utilized simplified scalable Suzuki coupling C−C bond formation metal‐free C−N sequence to synthesize functionalized scaffold from single intermediate. Subsequently, either functional group manipulations or late‐stage pyran ring annulation furnished library 13 alkaloids mostly isolated traditional medicinal plant Murraya...
An unprecedented allyl migration from a remote position of quinazoline moiety through ruthenium(II) shuttle is reported. This present cascade reaction initiated the formation an η3-ruthenium–allyl complex followed by C–H allylation at ortho 2-aryl moiety. Finally, hydroamination with quinazolinone -NH group, which formed tautomerization quinazoline, furnishes annulation product. exceedingly fast complete within 10 minutes to provide rutaecarpine analogues in single operation.