A5056317380- Dental Radiography and Imaging
- Radiation Dose and Imaging
- Oral and Maxillofacial Pathology
- Dental Implant Techniques and Outcomes
- Bone health and treatments
- dental development and anomalies
- Advanced X-ray and CT Imaging
- Periodontal Regeneration and Treatments
- Bone and Dental Protein Studies
- Bone Tissue Engineering Materials
- Parathyroid Disorders and Treatments
- Oral health in cancer treatment
- Oral and gingival health research
- Mesenchymal stem cell research
- Dental Trauma and Treatments
- Effects of Radiation Exposure
- Wnt/β-catenin signaling in development and cancer
- Tissue Engineering and Regenerative Medicine
- Head and Neck Cancer Studies
- Image and Signal Denoising Methods
- Bone and Joint Diseases
- Bone Tumor Diagnosis and Treatments
- Endodontics and Root Canal Treatments
- Anatomy and Medical Technology
- Alkaline Phosphatase Research Studies
Laboratory Orofacial Pathologies, Imaging and Biotherapies
2013-2024
Sorbonne Paris Cité
2012-2024
Hôpital Bretonneau
2010-2024
Assistance Publique – Hôpitaux de Paris
2013-2024
Université Paris Cité
2013-2024
University of Birmingham
2022-2023
Stanford Medicine
2014-2022
Belgian Nuclear Research Centre
2021
Universidade Estadual de Campinas (UNICAMP)
2018-2021
Stanford University
2017-2020
Abstract Tissue engineering strategies based on implanting cellularized biomaterials are promising therapeutic approaches for the reconstruction of large tissue defects. A major hurdle reliable establishment such is lack rapid blood perfusion construct to provide oxygen and nutrients. Numerous sources mesenchymal stem cells (MSCs) displaying angiogenic potential have been characterized in past years, including adult dental pulp. Establishment efficient improving angiogenesis constructs...
Digit length ratios, especially the second-to-fourth digit ratio (2D : 4D), are associated with various pathological and behavioural conditions in many species including humans dependent upon prenatal androgen to oestrogen balance. It is unknown whether ratios modified by environmental exposure ubiquitous endocrine disruptors. We studied effect on adult male Wistar rat of a gestational oestrogenic antiandrogenic compounds bisphenol A (BPA), genistein vinclozolin, low doses, combination...
Bone condensation is thought to densify interfacial bone and thus improve implant primary stability, but scant data substantiate either claim. We developed a murine oral model test these hypotheses. Osteotomies were created in healed maxillary extraction sites 1) by drilling or 2) followed stepwise with tapered osteotomes. Condensation increased density, as measured significant change volume/total volume trabecular spacing, it simultaneously damaged the bone. On postimplant day 1, condensed...
Cone beam CT (CBCT) for dentomaxillofacial paediatric assessment has been widely used despite the uncertainties of risks low-dose radiation exposures. The aim this work was to investigate clinical performance different CBCT acquisition protocols towards optimization Custom-made anthropomorphic phantoms were scanned using a unit in six protocols. slices blinded, randomized and presented three observers, who scored image quality 4-point scale along with their level confidence. Sharpness also...
Aging is associated with a function decline in tissue homeostasis and repair. also an increased incidence osteopenia osteoporosis, but whether these low bone mass diseases are risk factor for delayed healing still remains controversial. Addressing this question of direct clinical relevance dental patients, since most implants performed older patients who at developing conditions. The objective study was to assess how osteopenic/osteoporotic phenotype affected the rate new alveolar formation....
A variety of clinical classification schemes have been proposed as a means to identify sites in the oral cavity where implant osseointegration is likely be successful. Most are based on structural characteristics bone, for example, relative proportion densely compact, homogenous (type I) bone versus more trabeculated, cancellous III) bone. None these schemes, however, consider potential biological Here, we employed multiscale analyses and characterize type I III bones murine jaws. We then...
Background Previous studies have highlighted the increased risk of contracting COVID-19 for health-care workers and suggest that oral may carry greatest risk. Considering transmission route SARS-CoV-2 infection, a similar can be hypothesized other respiratory infections. However, no study has specifically assessed within dental profession. Methods An online survey was conducted population French professionals between April 1 29, 2020. Univariable multivariable logistic regression analyses...
Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X-chromosome) cause X-linked familial hypophosphatemic rickets (XLH), a disorder having severe bone and tooth dentin mineralization defects. The absence of functional leads abnormal accumulation ASARM (acidic serine- aspartate-rich motif) peptide - substrate for strong inhibitor derived from MEPE (matrix extracellular phosphoglycoprotein) other matrix proteins. MEPE-derived accumulates XLH patients where it...
ABSTRACT Claudin-16 protein (CLDN16) is a component of tight junctions (TJ) with restrictive distribution so far demonstrated mainly in the kidney. Here, we demonstrate expression CLDN16 also tooth germ and show that claudin-16 gene mutations result amelogenesis imperfecta (AI) 5 studied patients familial hypomagnesemia hypercalciuria nephrocalcinosis (FHHNC). To investigate role formation, murine model FHHNC showed deficiency led to altered secretory ameloblast TJ structure, lowering...
The treatment of mucoceles by the Lynch-Howarth frontoethmoidectomy has been criticized because a high rate recurrence and postoperative complications. long-term results in 60 patients treated this method are examined to evaluate these criticisms. Compared with osteoplastic flap-obliterative procedure, our suggest much lower (4%) considerably better cosmesis frontoethmoidectomy. This is achieved use fenestrated Silastic drainage tube left place for five months careful positioning scar....
Objectives: To assess the influence of artefacts arising from metallic materials in exomass on cone beam CT (CBCT) voxel values. Methods: CBCT scans were taken a phantom composed 16 tubes filled with homogeneous hyperdense solution and different compositions (titanium, cobalt–chromium amalgam) numbers (one, two three). The was centred 5 × cm field view such that located exomass, using three units. Voxel values obtained areas averaged. Also, standard deviation calculated to measure value...
Cell-based partial pulp regeneration is one of the promising approaches to obtain newly formed functional dentin-pulp complex. It relies on preservation healthy tissue while regenerating damaged pulp. The aim this study was investigate whether regenerative process could be achieved by implanting porcine dental cells (pDPCs) in defects minipig. By split-mouth model, self-assembling injectable nanopeptide hydrogel, with and without pDPCs, implanted after cameral pulpotomy premolars molars. At...
An increasing number of CBCT units and a wide variability radiation doses have been reported in dentistry lately.To estimate the effective, cumulative, organ absorbed children exposed to over 2 years.A prospective study was conducted who underwent diagnostic imaging with ProMax3D machine. Organ effective were calculated by Monte Carlo simulation using 5- 8-year-old pediatric voxel phantoms. Extrapolation procedures applied for other ages protocols used clinical conditions.The median dose...
Mutations in phosphate-regulating gene (PHEX) lead to X-linked hypophosphatemic rickets (XLH), a genetic disease characterized by impaired mineralization bones and teeth. In human XLH tooth dentin, calcospherites that would normally merge as part of the process are separated unmineralized interglobular spaces where fragments matrix proteins accumulate. Here, we immunolocalized osteopontin (OPN) teeth, three-dimensional dental pulp stem cell-collagen scaffold culture model rat injury repair...
Since MMPs have been suggested to contribute dentin caries progression, the hypothesis that MMP inhibition would affect progression of is clinically relevant. Grape seed extracts (GSE) previously reported be natural inhibitors MMPs. Objective: To evaluate capacity a GSE mouthrinse prevent degradation demineralized matrix by MMP-3 (stromelysin-1). Material and methods: Standardized blocks obtained from sound permanent teeth extracted for orthodontic reasons were with EDTA pretreated either...
This report aims to describe the development of age-specific phantoms for use in paediatric dentomaxillofacial radiology research. These are denoted DIMITRA skull as these have been primarily developed and validated European research project (Dentomaxillofacial imaging: an investigation towards low-dose radiation induced risks).To create phantoms, six human skulls with estimated ages ranging between 4 10 years- old were selected, protected non-radiopaque tape immersed melted Mix-D soft...