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Joshua Saskin

ORCID: 0000-0001-5372-9696
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About
Contact & Profiles
A5093671035
Research Areas
  • melanin and skin pigmentation
  • Biochemical Analysis and Sensing Techniques
  • Regulation of Appetite and Obesity
  • Neuroendocrine regulation and behavior
  • Circadian rhythm and melatonin
  • Skin Protection and Aging

Brown University
 2024-2025

 Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans
OPENALEX - Publications 
Yuanqing Feng Ning Xie Fumitaka Inoue Shaohua Fan Joshua Saskin and 13 more Chao Zhang Fang Zhang Matthew E.B. Hansen Thomas Nyambo Sununguko Wata Mpoloka Gaonyadiwe George Mokone Charles Fokunang Gurja Belay Alfred K. Njamnshi Michael S. Marks Elena Oancea Nadav Ahituv Sarah A. Tishkoff

10.1038/s41588-023-01626-1 article EN Nature Genetics 2024-01-10
 Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption
OPENALEX - Publications 
Hala K. Haddad Jonathan I. Mercado-Reyes Emilio Román Mustafá Shane P. D’Souza Chun‐Shiang Chung and 9 more Ramses R. M. Nestor Lauren E. Olinski Valentina Martínez Damonte Joshua Saskin Shruti Vemaraju Jesica Raingo Julie A. Kauer Richard A. Lang Elena Oancea

Mammalian opsin 3 (OPN3) is a member of the family G-protein-coupled receptors with ambiguous light sensitivity. OPN3 was first identified in brain (and named encephalopsin) and subsequently found to be expressed other tissues. In adipocytes, necessary for responses that modulate lipolysis glucose uptake, while human skin melanocytes regulates pigmentation light-independent manner. Despite its initial discovery brain, functional mechanisms remain elusive. Here, we investigated molecular...

10.1073/pnas.2403891122 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2025-02-14
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