A5044018192- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Advancements in Battery Materials
- Supercapacitor Materials and Fabrication
- Advanced Battery Materials and Technologies
- Circular RNAs in diseases
- Crystallization and Solubility Studies
- Acoustic Wave Phenomena Research
- Advanced Battery Technologies Research
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Evacuation and Crowd Dynamics
- Lung Cancer Research Studies
- X-ray Diffraction in Crystallography
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Sarcoma Diagnosis and Treatment
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Medical Imaging and Pathology Studies
Tianjin Medical University General Hospital
2016-2025
Beijing Institute of Technology
2024
China Automotive Battery Research Institute
2024
Grinm Advanced Materials (China)
2024
Shandong University of Technology
2023
Sichuan Highway Design and Research Institute
2023
Peking University
2015-2022
Wuhan University
2022
Xi'an University of Science and Technology
2022
Ministry of Education of the People's Republic of China
2021
Cardiac ischemia/reperfusion (I/R) injury has emerged as an important therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality worldwide. At present, there is no effective therapy reducing cardiac I/R injury. CaMKII (Ca2+/calmodulin-dependent kinase II) plays a pivotal role in pathogenesis severe conditions, including Pharmacological inhibition strategy protection against myocardial damage diseases. To date, drug targeting clinical disease. Furthermore, at...
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. However, science has not yet been able to substantially improve prognosis patients. Accumulating evidence suggests that microRNAs (miRNAs) are key players in regulation tumor development and metastasis. Expression six miRNAs previously shown play roles (miR-146b-5p, miR-128b, miR-21, miR-221, miR-34a, Let-7a) other types was examined using real-time RT-PCR 78 specimens NSCLC. The results revealed...
Significance Sex ratio is an important indicator of reproductive health, and its skewing reflects disturbed embryonic development. This study focused on sex skewing, which has recently identified in human vitro fertilization (IVF) babies. We reported herein that the skewed mouse IVF offspring was due to impaired imprinted X chromosome inactivation via suppressing ring finger protein 12 ( Rnf12 )/X-inactive specific transcript Xist ) pathway; can be corrected by overexpressing or...
The microRNA miR‐182, belonging to the miR‐183 family, is one of most frequently studied cancer‐related oncogenic miRNAs that dysregulated in various cancer tissues, and it plays a crucial role tumorigenesis tumor progression. Studies revealed miR‐182 might function as an or suppressor miRNA different tissues. However, development lung remains largely unknown. expression samples from 58 patients, normal tissue samples, cell lines were evaluated by qRT‐PCR. Survival curves analyzed using...
Leydig cells play a critical role in male reproductive physiology, and their dysfunction is usually associated with infertility. Melatonin has an important protective regulatory these cells. However, the lack of suitable animal models impedes us from addressing impact endogenous melatonin on In current study, by using arylalkylamine N-acetyltransferase (AANAT) overexpression transgenic sheep AANAT knockout mice, we confirmed effects endogenously occurring as well its beneficial performance....
Although metastasis remains the overwhelming cause of death for patients with non-small cell lung cancer (NSCLC), underlying mechanisms remain unknown. Accumulating evidence suggests that microRNAs (miRNAs) are key players in regulation tumor invasion and metastasis. Expression miR-9, miR-10b, miR-145, miR-155, 4 miRNAs previously shown to play roles other types, was compared lymph node (LN)-positive NSCLC versus LN-negative NSCLC. miR-145 significantly lower LN-positive (P < 0.05), while...
Circulating tumor DNA (ctDNA) isolated from plasma has great potential in identification of gene mutation non-small cell lung cancers (NSCLC), which is a non-invasive technique and can avoid the inherent shortcomings tissue biopsy. However ability NGS to detect ctDNA not been broadly explored. To assess diagnostic for total profile, including single nucleotide variations (SNVs), insertions deletions (indels) rearrangements, we performed targeted sequencing approach screen NSCLC related...
Purpose: Lung cancer is a major cause of morbidity and mortality globally, necessitating the identification predictive markers for effective immunotherapy.Mutations in SWI/SNF chromatin remodeling complex genes were reported sensitized human tumors to immune checkpoint inhibitors (ICIs), but underlying mechanisms are unclear.This study aims investigate association between gene ARID1B mutation ICI response non-small cell lung (NSCLC) patients, explore functional consequences on DNA damage...
Lung cancer is the leading malignancy in China terms of both incidence and mortality. With increased health awareness widespread use low-dose computed tomography (CT), early diagnosis rates have been steadily improving. Surgical intervention remains primary treatment option for early-stage lung cancer, video-assisted thoracoscopic surgery (VATS) has become a common approach due to its minimal invasiveness rapid recovery. However, post-discharge recovery incomplete, underscoring importance...
Analyzing cells and tissues under a microscope is cornerstone of biological research clinical practice. However, the challenge faced by conventional microscopy image analysis fact that cell recognition through still time-consuming lacks both accuracy consistency. Despite enormous progress in computer-aided detection, especially with recent deep-learning-based techniques, it difficult to translate an established method directly new target without extensive modification. The morphology complex...
Abstract A substantial number of mouse genes, about 25%, are embryonically lethal when knocked out. Using current genetic tools, such as the CRISPR-Cas9 system, it is difficult—or even impossible—to produce viable mice with heritable mutations. Here, we establish a one-step method for microinjection CRISPR reagents into one blastomere two-cell embryos to generate chimeric founder mutation, either Virma or Dpm1 . By examining mice, identify phenotype and role in regulating kidney metabolism...
Objective. To explore and analyze the effects of acupuncture medical treatment at different times on gastrointestinal reaction leukocyte count patients with lung cancer undergoing chemotherapy. Methods. Select 224 chemotherapy admitted to our hospital randomly divide them into three groups: control group ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>n</mi> <mo>=</mo> <mn>76</mn> </math> ), study 1 id="M2"> <mn>78</mn> 2 id="M3"> <mn>70</mn> ). The was treated tropisetron...
Abstract Background This study aimed to investigate the role of MIR17HG in non-small cell lung cancer (NSCLC). Methods Differential expression NSCLC was first detected by exploring TCGA dataset. Expression levels miR-142-3p both and non-tumor tissues were determined qPCR. The effects overexpressing on methylation miR-142 assessed MSP. MIR17HG, Bach-1 invasion migration cells Trasnwell or assay. Results Analysis dataset revealed slightly downregulated NSCLC. downregulation further confirmed...
Postoperative pneumonia (POP) is a hospital acquired that occurs >48 hours after tracheal intubation. The diagnosis of POP should be based on clinical and radiological findings within 30 days surgery. It common complication thoracoscopic surgery for lung cancer patients. However, the specific impact preoperative comorbidities incidence remains unclear. This study aimed to analyze data patients with help surgeons predict risk resection.
Aims: In addition to pineal gland, many cells, tissues, and organs also synthesize melatonin (N-acetyl-5-methoxytryptamine). Embryos are a group of special cells whether they can is still an open question. However, application promoted embryo development in species vitro condition. The purpose this study was investigate embryos melatonin; if it so, what the impacts endogenously produced on associated molecular mechanisms. These have never been reported previously. Results: Melatonin...
Developing liquid biopsy technology with higher sensitivity and specificity especially for low-frequency mutations remains crucial. This study demonstrated superior performance of the newly developed digital PCR (dPCR) kit ctDNA-based EGFR p.T790M detection in metastatic non-small-cell lung cancer (NSCLC) against ARMS-PCR.This large-scale, multi-centered diagnostic recruited 1,045 patients including 1,029 diagnosed advanced NSCLC 16 specific samples between April 1st 2018 November 30th 2019....
Primary pulmonary mucoepidermoid carcinoma (PMEC) is extremely rare. Herein, we report a case of 71‐year‐old male patient with high‐grade PMEC involving the right upper lobe that was successfully resected via lobectomy. As result invasion into pleural and paratracheal lymph nodes, four cycles adjuvant chemotherapy paclitaxel carboplatin were administered. There no signs relapse during 10 months follow‐up. Furthermore, reviewed literature summarized surgical approaches, prognostic factors,...
Studies have found that Lnc LINC00461 is an important regulator of cancer. However, the function in NSCLC not known. Therefore, this experimental design was based on to explore pathogenesis Non-small cell lung cancer (NSCLC). RT-qPCR used detect expression lnc and miR-30a-5p NSCLC. The CCK-8 method Transwell assay were effects proliferation, migration Target gene prediction screening, luciferase reporter assays validate downstream target genes miR-30a-5p. protein ZEB2 detected by Western...
Novel coronavirus pneumonia (NCP), which has swept across China and emerged in several countries around the world since December 2019, attracted global attention. NCP had a huge impact on world's medical, political economic sectors. Since March, under efforts of Chinese government, people guidance "New Coronavirus Pneumonia Diagnosis And Treatment Program (Trial Version 7)" issued by The National Health Commission, PRC...
Background: The incidence of venous thromboembolism (VTE) is higher in patients with lung cancer. aim this study was to investigate the risk factors associated postoperative VTE and explore predication capacity D-dimer kinetics. Patients Methods: Six hundred who had tumor surgery were analyzed retrospectively between January 2018 August 2019, ultrasound imaging examination before after recommended all operative patients. Of these 600 patients, 523 surgery, 77 not found. general clinical...