A5100433588- Cancer Mechanisms and Therapy
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- RNA modifications and cancer
- Analytical chemistry methods development
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Lung Cancer Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Medicinal Plant Pharmacodynamics Research
- Alzheimer's disease research and treatments
- Ginseng Biological Effects and Applications
- Food Quality and Safety Studies
- Telomeres, Telomerase, and Senescence
- Epilepsy research and treatment
- Retinal Development and Disorders
- Higher Education Governance and Development
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Photoreceptor and optogenetics research
- Bipolar Disorder and Treatment
Nanjing Medical University
2011-2024
Jiangsu Province Hospital
2023
Shandong University of Traditional Chinese Medicine
2022
Zhejiang University
2021
Nanjing Chest Hospital
2021
Nanjing Brain Hospital
2021
Guangzhou University of Chinese Medicine
2021
Wuxi People's Hospital
2020
Xiamen University
2017
Zhejiang Chinese Medical University
2016
Major depressive disorder (MDD) is one of the most common mental disorders. We designed a fast-onset antidepressant that works by disrupting interaction between serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in dorsal raphe nucleus (DRN). Chronic unpredictable mild stress (CMS) selectively increased SERT-nNOS complex DRN mice. Augmentation interactions caused depression-like phenotype accounted for CMS-induced behaviors. Disrupting produced effect enhancing signaling...
The molecular mechanism of memory formation remains a mystery. Here, we show that TERT, the catalytic subunit telomerase, gene knockout (Tert-/-) causes extremely poor ability in spatial formation. Knockdown TERT dentate gyrus adult hippocampus impairs processes, while overexpression facilitates it. We find plays critical role neural development including dendritic and neuritogenesis hippocampal newborn neurons. A monosynaptic pseudotyped rabies virus retrograde tracing method shows is...
Summary In neurons, increased protein–protein interactions between neuronal nitric oxide synthase ( nNOS ) and its carboxy‐terminal PDZ ligand CAPON contribute to excitotoxicity abnormal dendritic spine development, both of which are involved in the development Alzheimer's disease. models disease, – interaction was detected after treatment with amyloid‐β vitro, a similar change found hippocampus APP / PS 1 mice (a transgenic mouse model disease), compared age‐matched background vivo . After...
Developing liquid biopsy technology with higher sensitivity and specificity especially for low-frequency mutations remains crucial. This study demonstrated superior performance of the newly developed digital PCR (dPCR) kit ctDNA-based EGFR p.T790M detection in metastatic non-small-cell lung cancer (NSCLC) against ARMS-PCR.This large-scale, multi-centered diagnostic recruited 1,045 patients including 1,029 diagnosed advanced NSCLC 16 specific samples between April 1st 2018 November 30th 2019....
Methyltransferase-like protein 3 (METTL3) mediated N6-Methyladenosine (m6A) modification has been implicated in many physiological and pathological processes. However, its function mechanism kidney aging are not entirely clear. Here, we investigated changes m6A levels of kidneys the role METTL3 senescent renal tubular epithelial cells potential mechanisms. First, used naturally aged mouse model D-galactose (D-gal)-induced model. Dot blot RNA methylation quantification showed significantly...
The protein-protein interaction between neuronal nitric oxide syntheses (nNOS) and the carboxy-terminal PDZ ligand of nNOS (CAPON) is a potential target for treatment ischemic stroke. Our previous study had identified ZLc-002 as promising lead compound inhibiting nNOS-CAPON coupling. To find better neuroprotective agents disrupting ischemia-induced interaction, series N-cyclohexylethyl-[A/G]-[D/E]-X-V peptides based on tetrapeptide CAPON was designed, synthesized, evaluated in this study....
Compound Phyllanthus urinaria L. (CP) is a traditional Chinese medicine (TCM) formula for cancer treatment in the clinic, particularly during progression of hepatitis B-associated hepatocellular carcinoma (HBV-associated HCC). Nevertheless, its anti-metastatic action and mechanisms are not well elucidated. In this study, CP was found to exert remarkable inhibitory effects on proliferation, migration invasion HBV-associated HCC cells. The following network biological analyses predicted that...
Depression is the leading cause of global burden disease and disability. Abnormalities in kynurenine pathway tryptophan degradation have been closely linked to pathogenesis depression. An integrative bioinformatics analysis demonstrated that indoleamine 2,3-dioxygenase 1 (IDO1) (TDO) are potential targets for development antidepressants. A series 1-(hetero)aryl-β-carboline derivatives were designed, synthesized, evaluated as novel IDO1/TDO dual inhibitors. Among them, compound 28 displayed...
A recent study synthesized several published genome-wide association studies (GWAS) on three types of cancers and identified variants at 6p21.1 7p15.3 as candidate susceptibility loci for multiple human cancers. However, the role these in development head neck cancer (HNC) is still unclear.To evaluate relationships between genetic regions HNC risk, we genotyped two common SNPs rs2494938 rs2285947 a case-control with total 503 cases 900 controls Han Chinese.We found that was associated...
Vanderbylia robiniophila (Murrill) B.K. (Huaier) is a kind of higher fungal fruiting body that parasitic on the trunk Sophora japonica and Robinia pseudoacacia L.. As traditional Chinese medicine with history more than 1,600 years, Huaier has attracted wide attention for its excellent anticancer activity. A systematic study metabolome differences between natural artificial cultured was conducted using liquid chromatography-mass spectrometry in this study. Principal component analysis...
Abstract In the scope of stroke treatment, new neuronal nitric oxide synthase–postsynaptic density protein‐95 uncouplers from herbal medicines were discovered and captured. To do so, highly selective magnetic molecularly imprinted polymers with a core–shell structure prepared as artificial antibodies. According to results computational simulations, we designed synthesized various varying amounts types template, functional monomer, cross‐linker, solvent. Characterization performance tests...
Accumulating evidence indicates that epilepsy has a higher risk of inducing memory impairment and dementia. However, the underlying onset mechanism remains unclear. Here, we found mice with spontaneous induced by endothelial CDK5 deficiency exhibited hippocampal-dependent at 6 months age, but not 2 age. Moreover, persistent epileptic seizures induce aberrant changes in phosphorylation CaMKII protein hippocampus mice. Using genome-wide RNA sequencing intergenic interaction analysis STRING,...
Objective: To investigate the effect of Panax notoginseng saponins (PNS) on ischemia reperfusion (I/R) induced rat mesenteric microcirculatory dysfunctions. Methods: Male Wistar rats weighting 200–250 g were subjected to 10 min ligation superior artery and vein, followed by 60 reperfusion. PNS (5 mg/kg/hr) was continuously administrated starting from before or after until via left jugular vein. Leukocytes adhesion, mast cell degranulation, endothelial peroxidation, albumin leakage venules...
<p>Supplementary Fig S6</p>